2021
DOI: 10.1159/000521305
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Immunometabolism: Where Immunology and Metabolism Meet

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Cited by 24 publications
(16 citation statements)
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“…Inflammation, oxidative stress and mitochondrial dysfunction in non-alcoholic fatty liver disease and mental illness Systemic inflammation, characteristic of chronic diseases such as obesity and diabetes, contributes to both psychiatric disorders and NAFLD. The relationship between inflammation and metabolic liver diseases (NAFLD/NASH) is both causal and reciprocal, an example of immunometabolic disease (Katsarou et al, 2020;Chavakis, 2022). Inflammatory signals resulting from lipid peroxidation are critical to the development of NAFLD, and multiple factors contribute to the onset of hepatic lipid peroxidation.…”
Section: Mechanistic Synergies Between Non-alcoholic Fatty Liver Dise...mentioning
confidence: 99%
“…Inflammation, oxidative stress and mitochondrial dysfunction in non-alcoholic fatty liver disease and mental illness Systemic inflammation, characteristic of chronic diseases such as obesity and diabetes, contributes to both psychiatric disorders and NAFLD. The relationship between inflammation and metabolic liver diseases (NAFLD/NASH) is both causal and reciprocal, an example of immunometabolic disease (Katsarou et al, 2020;Chavakis, 2022). Inflammatory signals resulting from lipid peroxidation are critical to the development of NAFLD, and multiple factors contribute to the onset of hepatic lipid peroxidation.…”
Section: Mechanistic Synergies Between Non-alcoholic Fatty Liver Dise...mentioning
confidence: 99%
“…At the interface and cross-talk of immunology and metabolism, the cellular metabolism regulates the fate, function and activation of the immune cells [ 77 ]. Metabolic adaptations and epigenetic reprogramming are involved in macrophage plasticity and phenotype change ( Figure 4 ) [ 77 , 78 , 79 , 80 , 81 ]. Glut1 is also essential for the homeostasis of T and B lymphocytes [ 82 , 83 ].…”
Section: Glut-1 Deficiency In Other Tissues: Expanding the Clinical P...mentioning
confidence: 99%
“…16,22 This intersection between the immune system and metabolism is termed the immunometabolism endophenotype. 23 Immune cells, such as macrophages, T cells, and dendritic cells, undergo significant metabolic changes in response to different stimuli. 24 Reciprocally, metabolic signals, such as glucose, fatty acids, and amino acids, modulate immune cell functions.…”
Section: Introductionmentioning
confidence: 99%
“…Importantly, AD is no longer considered exclusively a central nervous system (CNS) disease; rather, recent studies implicate important roles in AD for neuro‐ and systematic inflammation 20,21 and cellular metabolism 16,22 . This intersection between the immune system and metabolism is termed the immunometabolism endophenotype 23 …”
Section: Introductionmentioning
confidence: 99%