Immunomodulation of autoimmune and inflammatory diseases with intravenous immunoglobulin

Ephrem, Amal; Misra, Namita; Hassan, Gazzala; Dasgupta, Suryasarathi; Delignat, Sandrine; Huyen, Duong Van; Chamat, Soulaïma; Prost, Fabienne; Lacroix‐Desmazes, Sébastien; Sv, Kavery; Kazatchkine,

doi:10.1007/s10238-005-0079-y

Cited by 66 publications

(45 citation statements)

References 45 publications

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“…(iii) It is well known that the broad antibacterial activity of natural occurring Ab is mainly due to IgM Ab with low specificity and polyreactivity to polysaccharides (16,28 The administration of pooled IVIG is believed to have "immunomodulatory" effects on autoimmune and inflammatory diseases. Thus, IVIG is also used in ABOi kidney transplantation (7,13,33,34 …”

Section: The Effect Of Intravenous Immunoglobulins and Rituximab On Amentioning

confidence: 99%

Changes of Circulating Antibody Levels Induced by ABO Antibody Adsorption for ABO-Incompatible Kidney Transplantation

Valli

Yung

Fehr

et al. 2009

American Journal of Transplantation

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ABO-incompatible kidney transplantation using immunoadsorption to remove anti-A/B antibodies has become a successful clinical practice. Since the data on the specificity of the ABO columns are controversial, the present study assessed the efficiency and specificity of the ABO immunoadsorption, the effect on total immunoglobulins and antibodies previously induced by vaccination. Anti-A/B antibodies were measured by agglutination and ABO flow cytometry, total IgG/IgM, carbohydrate-and protein-specific antibodies by nephelometry and ELISA. The first immunoadsorption not only efficiently reduced donor-specific anti-A/B IgM (81%) and IgG (56%) but also reduced compatible anti-A/B IgM (59%) and IgG (34%). The measurements of antidonor A/B antibodies by direct agglutination (IgM) or flow cytometry better represented the effective antibody levels than the indirect agglutination test (IgG). The median reduction of total IgM and total IgG levels after a single immunoadsorption was 34% and 18%, respectively. Antibodies against pneumococcus and haemophilus polysaccharide antigens were significantly reduced, whereas antitetanus and antidiphtheria protein antibodies were not affected. Intravenous immunoglobulin administration restored the protective anticarbohydrate antibody levels. In summary, immunoadsorption efficiently removed antidonor A/B antibodies, but was not specific for A/B antigens. Anti-A/B antibody levels as determined by ABO flow cytometry are useful to establish the minimal number of immunoadsorptions needed for successful ABO-incompatible transplantation.Key words: ABO blood group, ABO incompatible kidney transplantation, flow cytometry, immunoadsorption AbbreviationsABOi, ABO-incompatible; a Gal, Gala 1-3Gal antigen; DAT, direct agglutination test; IA, immunoadsorption; IAT, indirect antiglobulin tests; IVIG, intravenous immunoglobulin; MFIR, geometric mean fluorescence intensity ratio; RBC, red blood cell.

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Section: The Effect Of Intravenous Immunoglobulins and Rituximab On Amentioning

confidence: 99%

Changes of Circulating Antibody Levels Induced by ABO Antibody Adsorption for ABO-Incompatible Kidney Transplantation

Valli

Yung

Fehr

et al. 2009

American Journal of Transplantation

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“…-stimulating production of some of the cytokines and their antagonists [27][28][29][30]; -stimulating B & T lymphocyte apoptosis by activating Fas receptors [28,31]; -inhibiting differentiation and maturation of dendritic cells [32]; -increasing catabolism of IgG [28,29]; -modulating expression and function of an Fc fragment through FcγR receptors [29,30,33];…”

Section: Mechanism Of Action and Clinical Usementioning

confidence: 99%

Immunoglobulins and Their Use in Children

Łaguna¹,

Gołębiowska-Staroszczyk²,

Trzaska³

et al. 2015

Adv Clin Exp Med

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Immunoglobulin preparations are one of the products of the human plasma fractionation, where the plasma is obtained, in accordance with WHO guidelines from at least 1,000 donors. These preparations contain all IgG subclasses with various antigen characteristics. In clinical practice these drugs are used as replacement therapy in patients with primary and secondary immunodeficiencies as well as immunomodulatory therapy in many autoimmune diseases and systemic inflammatory diseases. Here we present characteristics of i.v. polyvalent, human immunoglobulin preparations available on the Polish market and the possibilities of their use in clinical practice, in children with hematological diseases. Considering the very low consumption of immunoglobulin preparations in our country as compared to other European countries, we would like to draw the attention of medical professionals, especially pediatricians and haematologists, to the benefits that stem from the use of these drugs in the therapy of children with haematological diseases. Our work will also facilitate the choice of an optimal polyvalent human immunoglobulin preparation for a particular patient (Adv Clin Exp Med 2015, 24, 1, 153-159).

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“…Guillain-Barré syndrome [25][26][27][28][29] Chronic inflammatory demyelinating polyneuropathy [25][26][27][28][29] Multiple motor neuropathy [26,27] Multiple sclerosis [26,27] Myasthenia gravis [26][27][28] Acute disseminated encephalomyelitis [27] Diabetic neuropathy [27] Lambert-Eaton myasthenic syndrome [27] Opsoclonus-myoclonus [27] Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections [27] Polymyositis [27,[30][31][32] Rasmussen's encephalitis [27] Multiple sclerosis [33] Table 3: List of neurological diseases where the use of intravenous immunoglobulins (IVIG) has been used successfully.…”

Section: Diseases Referencesmentioning

confidence: 99%

Autoimmunity in Neurological and Psychiatric Disorders: Participation of Antibodies and Cytokines in the Immunopathogenesis of these Diseases

Vaillant¹

2014

Immunome Res

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Immunomodulation of autoimmune and inflammatory diseases with intravenous immunoglobulin

Cited by 66 publications

References 45 publications

Changes of Circulating Antibody Levels Induced by ABO Antibody Adsorption for ABO-Incompatible Kidney Transplantation

Changes of Circulating Antibody Levels Induced by ABO Antibody Adsorption for ABO-Incompatible Kidney Transplantation

Immunoglobulins and Their Use in Children

Autoimmunity in Neurological and Psychiatric Disorders: Participation of Antibodies and Cytokines in the Immunopathogenesis of these Diseases

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