Immunomodulation: TIVA versus VIMA

Waly, Salwa H.; Baqi, Hossam Abdel; Nasr, Yasser M.; Alazizi, Nashwa M.; Atfy, Maha

doi:10.1016/j.egja.2011.07.003

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…A study by Mustafa and colleagues [16] thought that the immune suppression produced by TIVA with propofol is related to the high lipid content of propofol preparations and may be attributed to its release of cytokines. However, this study differs from the current study in that we compared total intravenous general anesthesia with propofol versus total inhalation general anesthesia with sevoflurane, while that study compared two intravenous agents [ propofol vs thiopental ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Study between the Effect of two Anesthetic Agents and Techniques on the Immune System

Gadalla¹,

Abdelazem²,

Mosad³

et al. 2018

Benha Journal of Applied Sciences

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General anesthesia and surgical stress have a major role in affecting patients' cellular immunity. Different anesthetic techniques may have different effects on the immune response of patients undergoing the same type of surgery. Comparing the effects of two types of anaesthesia on immunological and neurohormonal responses to anaesthesia and surgical stress. Forty patients were assigned to undergo either volatile induction or maintenance of anaesthesia [VIMA] with sevoflurane or total intravenous anaesthesia [TIVA] with propofol. Plasma cortisol, glucose and CRP levels were measured, A blood sample was collected 24 h before surgery [Sbasal] to achieve the basal findings of the patient. The first sample on the day operation was collected just before the induction of anesthesia [S1] , the second sample was collected 2 h later after induction [S2] and the third sample was collected 24 h after surgery [S3]. VIMA with sevoflurane is less immunosuppressive than TIVA with propofol in patients undergoing surgery. Further studies will be needed to ensure that these results could help anesthetists to select safer anesthetic circumstances especially for immunocompromised patients performing different types of surgeries. TIVA reduce stress hormone responses compared with VIMA. This result suggest that TIVA with propofol may has advantages over VIMA with sevoflurane in stress related responses to surgery , including secretion of cortisol and glucose.

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Section: Discussionmentioning

confidence: 99%

Comparative Study between the Effect of two Anesthetic Agents and Techniques on the Immune System

Gadalla¹,

Abdelazem²,

Mosad³

et al. 2018

Benha Journal of Applied Sciences

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Inhalant anaesthetics

Scarabelli

Bradbrook²

2017

Companion Animal

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Inhalant anaesthetics are commonly used in veterinary medicine; a basic review of their physicochemical properties and pharmacokinetics and pharmacodynamics parameters is carried out in this article. Particular attention is paid to factors that may affect induction and recovery from anaesthesia, and to the drug side-effects, focused on the requirements of the general practitioner. Finally, there is be a brief discussion about occupational exposure and environmental contamination.

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Effects of Intravenous Anesthetic Drugs on Leukocytes for Patients Undergoing Surgery: A Diagnostic Clinical study

Rashid

Karim

Babakir‐Mina

2023

Preprint

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Background General anesthesia and intravenous anesthetic drugs influence the leukocytes. The study designed to assess the effects of intravenous anesthetics and anesthesia technique on leukocytes which are the important human immune cells. Methods The prospective study was performed on 100 patients undergoing surgery in Sulaimani Teaching and Shar Teaching Hospitals from November 2021 to March 2022. First blood sample were collected from the patients before induction and second sample were collected 6 hours after operation. Complete blood counts were done for all samples to find out the rates of leukocytes pre- and post-operative. Results In general, the mean of lymphocytes, monocytes, eosinophils and basophils counts were decreased after operation, but the mean of neutrophils counts were increased. General anesthesia was more effective to leukocytes than other types. All hypnotic anesthetic drugs were affecting the level of leukocytes except Pentothal. Patients who given analgesics had obvious effect on leukocytes than other who were not received analgesics. Also, leukocytes changes were shown for muscle relaxant, they decrease the level of lymphocytes, monocytes, eosinophils and basophils count, but increase the level of neutrophils. According to the leukocytes count, significant changes were found for most of the intravenous anesthetics (p < 0.05). Conclusion All hypnotic, analgesic, and muscle relaxant except Pentothal can decrease leukocytes especially, Lymphocytes. While, by using all the intravenous anesthetic drugs neutrophil counts elevation may occurs.

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Immunomodulation: TIVA versus VIMA

Cited by 4 publications

References 24 publications

Comparative Study between the Effect of two Anesthetic Agents and Techniques on the Immune System

Comparative Study between the Effect of two Anesthetic Agents and Techniques on the Immune System

Inhalant anaesthetics

Effects of Intravenous Anesthetic Drugs on Leukocytes for Patients Undergoing Surgery: A Diagnostic Clinical study

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