Immunomodulator polysaccharides: Chemistry, disposition and metabolism

Trnovec, T.; Hrmová, Mária

doi:10.1002/bdd.2510140302

Cited by 15 publications

(1 citation statement)

References 52 publications

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“…In addition, polysaccharides have been shown to be bioavailable in various in vivo and human clinical models after oral administration. [1819] Additionally, polysaccharides containing C. longa extracts have been shown to have anti-diabetic, anti-tumor, anti-depressant, anti-oxidant, anti-microbial, anti-fertility, immune-modulatory, and hepato protective properties. [920–26]…”

Section: Introductionmentioning

confidence: 99%

Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction

Chandrasekaran¹,

Sundarajan²,

Edwin³

et al. 2013

Phcog Res

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Background:While curcuminoids have been reported to possess diverse biological activities, the anti-inflammatory activity of polar extracts (devoid of curcuminoids) of Curcuma longa (C. longa) has seldom been studied. In this study, we have investigated immune-stimulatory and anti-inflammatory activities of an aqueous based extract of C. longa (NR-INF-02) and its fractions in presence and absence of mitogens.Materials and Methods:Effects of NR-INF-02 (Turmacin™, Natural Remedies Pvt. Ltd., Bangalore, India) on proliferation, nitric oxide (NO), monocyte chemotactic protein-1 (MCP-1), interleukins (ILs) and prostaglandin (PGE2) levels of mouse splenocytes and mouse macrophage (RAW264.7) cells were determined.Results:NR-INF-02 increased splenocytes number in presence and absence of lipopolysaccharide (LPS) or concanavalin A. Treatment of NR-INF-02 showed a significant increase of NO, IL-2, IL-6, IL-10, IL-12, interferon (IFN) gamma, tumor necrosis factor (TNF) alpha and MCP-1 production in unstimulated mouse splenocytes and mouse macrophages. Interestingly, NR-INF-02 showed potent inhibitory effect towards release of PGE2 and IL-12 levels in LPS stimulated mouse splenocytes. Further, NR-INF-02 was fractionated into polysaccharide fraction (F1) and mother liquor (F2) to study their immune-modulatory effects. F1 was found to be more potent than F2 toward inhibiting PGE2 and IL-12 in LPS stimulated splenocytes.Conclusion:Present findings revealed the novel anti-inflammatory property of NR-INF-02 and its polysaccharide fraction by inhibiting the secretion of IL-12 and PGE2 in vitro.

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Section: Introductionmentioning

confidence: 99%

Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction

Chandrasekaran¹,

Sundarajan²,

Edwin³

et al. 2013

Phcog Res

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Microbial Polysaccharides

Côté¹,

Ahlgren²

2000

Kirk-Othmer Encyclopedia of Chemical Technology

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Cote, Gregory L. and Ahlgren, Jeffrey A. (U.S. Dept. of Agriculture). Microbial polysaccharides are complex carbohydrate polymers produced by a variety of microorganisms. Those of commercial interest are generally produced extracellularly in substantial quantities. Commercial applications can be based on specific structural features or on physical properties. Applications based on physical properties include use as water‐soluble thickeners, gelling agents, and emulsion stabilizers. Applications based on specific structural features include the use of bacterial capsular antigens as vaccines, and the use of polysaccharides as metal complexants. Economically, the most important microbial polysaccharides are xanthan gum, dextran, and gellan. Others, such as pullulan, curdlan, and scleroglucan, are used less in the United States, but significant quantities are used overseas. Other microbial polysaccharides that show promise are bacterial cellulose, emulsan, liposan, levan, and succinoglucan. β‐ D ‐Glucans and sulfated polysaccharides are of interest as immunomodulators. Vol. 16, pp. 578–611, 372 refs. to November 1993.

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