Immunomodulator Vitamin C: An Adjuvant Therapy in Second Wave of Coronavirus Disease 2019

Kumar, Pradeep; Verma, Manish; Sharma, Rachna; Agrawal, Rohit; Singh, Surya Pratap; Jaiswal, Anoop; Prakash, Om; Soni, Navneet Omprakash; Verma, Poonam; Siddiqui, Areena Hoda; Gupta, Savita; Sharma, Preeti

doi:10.22207/jpam.16.3.46

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…To determine the connection between these markers and the general prognosis of patients with COVID-19 disease several investigations have been carried out. According to reports inflammatory indicators can predict death in COVID-19 disease patients [16]. One of the main causes of death in patients with severe COVID-19 disease has been related to the cytokine storm brought on by the release of pro-inflammatory factors similar to that documented in other infections [17].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Marker Variations in Predicting Deaths in COVID-19

Jain¹,

Saini²,

Rawat³

et al. 2023

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Introduction. Patients with coronavirus illness experienced a cytokine storm as a major cause of morbidity and mortality in 2019. (COVID-19). The goal of the study was to ascertain the predictive value of pro-inflammatory cytokines with regard to the overall prognosis of COVID-19 patients. Methods. This study was conducted by the Department of Microbiology, Santosh Medical College & Hospital, Ghaziabad, Uttar Pradesh from April to July 2021. We followed 189 patients hospitalized for suspected or confirmed COVID-19 from the day of hospitalization to the day of discharge or death. We measured serum IL-6, CRP, D – Dimer, Ferritin levels upon admission and correlated these results with clinical and laboratory markers of disease severity and with disease outcome. Results. Most of the patients were males and greater than 60 years of age. The mean ferritin level prior to the terminal event (survival or death) among non-survivors was 746 ng/mL as compared to 294 ng/mL among survivors and this difference was statistically significant (p-value <0.05). A decrease in ferritin levels prior to the terminal event (survival or death) and at admission were associated with a greater probability of survival. Ferritin levels prior to the terminal event were more strongly correlated with death than ferritin levels at baseline. Mean CRP level at admission among non-survivors was 69 mg/L as compared to 283 mg/L among survivors and this difference was not statistically significant (p >0.05). Conclusion. In patients with COVID-19, inflammatory markers have prognostic value, with higher levels being associated with worse outcomes.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Marker Variations in Predicting Deaths in COVID-19

Jain¹,

Saini²,

Rawat³

et al. 2023

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“…The study was carried out with the financial support of the Perm Scientific and Educational Center "Rational Subsoil Use", 2022. Показана потенциальная польза приема аскорбиновой кислоты в комплексном лечении данного заболевания, особенно у лиц с дефицитом витамина С. Авторы сообщают о снижении смертности, снижении риска прогрессирования органной недостаточности и улучшении результатов рентгенографии у пролеченных пациентов по сравнению с контролем [1][2][3][4].…”

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Study of the Influence of the Technological Regime of the Production of Water Extraction from Rosehip Fruits (<i>Rosae fructus</i>) on the Content of Ascorbic Acid

Собин

Korosteleva

Lutkova

et al. 2022

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. COVID-19 is recognized as the most significant pandemic of the modern era. Studies have shown the potential benefits of taking ascorbic acid in the complex treatment of this disease, especially in people with vitamin C deficiency. One of the most popular and affordable sources of ascorbic acid in the diet are rosehip fruits. The quality of water extracts from plant raw materials depends on a number of technological factors. The study of the influence of the technological regime of the production of water extraction from rosehip fruits on the release of ascorbic acid in the obtained dosage forms is relevant.Aim. To obtain water extracts from rosehip fruits by various production modes and to study the effect of technological parameters on the content of ascorbic acid.Materials and methods. The object of the study was rosehip fruits in bundles and water extracts based on them, obtained in the 6 different ways. Pharmacopoeial techniques, manufacturers' recommendations, as well as thermos infusion with and without preheating of the thermos flask were used. For quantitative determination of the ascorbic acid in the obtained aqueous extracts, we used the pharmacopoeia method (titration with 2,6-dichlorophenolindophenolate sodium).Results and discussion. The lowest content of ascorbic acid was noted in the decoction according to the pharmacopoeia method. High levels of ascorbic acid content were noted in the variants of thermos infusion of rosehip fruits.Conclusion. We have obtained extemporal water extracts of rosehip fruits by the 6 different extraction modes. According to the content of ascorbic acid, the most effective method of obtaining extemporal water extraction of rosehip fruits is a six-hour thermos infusion with preheating of the thermos flask. The largest amount of ascorbic acid is released during a six-hour thermos infusion. In the twelve-hour thermos infusions, a decrease in the amount of ascorbic acid was found. It was found that preheating the thermos flask leads to an increase in the yield of ascorbic acid in aqueous extraction by 25 %.

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Immunomodulator Vitamin C: An Adjuvant Therapy in Second Wave of Coronavirus Disease 2019

Cited by 2 publications

References 27 publications

Inflammatory Marker Variations in Predicting Deaths in COVID-19

Inflammatory Marker Variations in Predicting Deaths in COVID-19

Study of the Influence of the Technological Regime of the Production of Water Extraction from Rosehip Fruits (<i>Rosae fructus</i>) on the Content of Ascorbic Acid

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