Both patients and hospitals are harmed by hospital-acquired infection, sometimes known as “nosocomial infection.” To prevent these hospitals, require excellent disinfection and sterilization technologies, which are now integrated into a single department known as the central sterile supply department (CSSD).Aim is to study Organization, workload and the Quality Control Practices in CSSD. This descriptive, observational and hospital survey based study was carried out over a period of 6 months from November to April in Santosh Medical College & Hospital Ghaziabad. Monitoring of CSSD is done to oversee the use of different sterilization methods and capturing indicators to monitor sterilization process and ensure technical maintenance of the equipment according to National standards and manufacture’s recommendation. CSSD of the institution is centrally located within the hospital. Various articles including linen, dressings, surgical instruments and trays are sterilized in the CSSD. Sterilization is done by steam sterilization and gas sterilization with a total of seven autoclaves and two ETO machines. Physical, chemical are regularly used during the process of sterilization. CSSD of institute with proper practices of sterilization methods helps in continuous improvement required to decrease hospital acquired infections (HAIs).

Introduction. Patients with coronavirus illness experienced a cytokine storm as a major cause of morbidity and mortality in 2019. (COVID-19). The goal of the study was to ascertain the predictive value of pro-inflammatory cytokines with regard to the overall prognosis of COVID-19 patients. Methods. This study was conducted by the Department of Microbiology, Santosh Medical College & Hospital, Ghaziabad, Uttar Pradesh from April to July 2021. We followed 189 patients hospitalized for suspected or confirmed COVID-19 from the day of hospitalization to the day of discharge or death. We measured serum IL-6, CRP, D – Dimer, Ferritin levels upon admission and correlated these results with clinical and laboratory markers of disease severity and with disease outcome. Results. Most of the patients were males and greater than 60 years of age. The mean ferritin level prior to the terminal event (survival or death) among non-survivors was 746 ng/mL as compared to 294 ng/mL among survivors and this difference was statistically significant (p-value <0.05). A decrease in ferritin levels prior to the terminal event (survival or death) and at admission were associated with a greater probability of survival. Ferritin levels prior to the terminal event were more strongly correlated with death than ferritin levels at baseline. Mean CRP level at admission among non-survivors was 69 mg/L as compared to 283 mg/L among survivors and this difference was not statistically significant (p >0.05). Conclusion. In patients with COVID-19, inflammatory markers have prognostic value, with higher levels being associated with worse outcomes.