Immunomodulatory Activity of <i>Chlorophytum borivilianum</i> Sant. F

Thakur, Mayank; Bhargava, Shilpi; Dixit, Vinod Kumar

doi:10.1093/ecam/nel094

Cited by 63 publications

(32 citation statements)

References 13 publications

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“…) which exert such activities. Thakur et al (2006) observed similar findings with the root extract of Chlorophytum borivilianum. The oral administration of ethanolic and water extracts of Capparis zeylanica at doses of 150-300 mg kg -1 body wt showed a similar dose-related increase in the clearance rate of carbon by the cells of the RES (Ghule et al 2006).…”

Section: Discussionsupporting

confidence: 74%

“…In addition, Ghule et al (2006) also reported that Capparis zeylanica showed dose-dependent immunostimulatory activity in both alcohol and aqueous extracts. Thakur et al (2006) observed that sapogenin of ethanolic extract of Chlorophytum borivillanum induced stimulation of immune response in treated animals. In the present investigation, ethanolic and aqueous extracts of S. rebaudiana showed potent results, proving their immunostimulatory activities and showing that they could be effective candidates for the prevention of autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

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Comparative phytochemical analysis andin vivoimmunomodulatory activity of various extracts ofStevia rebaudianaleaves in experimental animal model

Shukla̽

Mehta

2014

Frontiers in Life Science

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The present study was undertaken to explore the comparative phytochemical analysis and immunomodulating activities of various successively extracted leaf extracts of Stevia rebaudiana (Bertoni) in albino rats. Phytochemical screening conducted on various organic leaf extracts of S. rebaudiana revealed the presence of several biologically active molecules that include sterols, saponins, alkaloids, glycosides, phenols, tannins, flavonoids and resins. The immunomodulatory activities were determined by neutrophil adhesion test, haemagglutination antibody (HA) titre delayed type hypersensitivity (DTH) response and phagocytic activity. The response produced by oral administration of ethanolic and aqueous leaf extracts showed a significant increase in neutrophil adhesion and DTH response. The augmentation of humoral immune response to sheep red blood cells by ethanolic and aqueous extracts at 300-500 mg kg -1 was higher than when an extract dose of 200 mg kg -1 was used, as shown by a dose-related increase in antibody titres in experimental rats. This study demonstrates potent immunomodulatory activities and therapeutic potential of phytochemical compounds extracted from S. rebaudiana leaf to combat against immunological disorders.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Comparative phytochemical analysis andin vivoimmunomodulatory activity of various extracts ofStevia rebaudianaleaves in experimental animal model

Shukla̽

Mehta

2014

Frontiers in Life Science

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“…It may use in infection condition, enhancement of immunological response against foreign particles or antigens, and improving defensive response under normal circumstances. [26] Ethanolic extract and aqueous extract of Picrorhiza kurroa have the ability to stimulate humoral response by acting various level of immune mechanism such as antibody production, release of mediators of hypersensitivity reactions, and tissue responses to these mediators in the target organs. [27] …”

Section: Effect On Innate Immune Systemmentioning

confidence: 99%

Immunomodulators: Role of medicinal plants in immune system

Sharma¹,

Kumar²,

Sharma³

et al. 2017

Natl J Physiol Pharm Pharmacol

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A broad range of health-care practices is required to exploit the beneficial effects of Ayurveda, which is the most ancient system of medicines. Being the essence of Ayurvedic medicines, Indian medicinal plants manifest miraculous effects in curing a vast range of diseases and disorders among humans and can be better called as "elixirs of life." Currently, there is much growing interest in the use of these medicinal plants as modulators of the complex immune system. Through a number of vast researches conducted in the area, it is being explored that many of the chemicals in the form of alkaloids, flavonoids, terpenoids, polysaccharides, lactones, and glycoside products are responsible to cause alterations in the immunomodulatory properties. Keeping in mind, the tremendous potential of the medicinal plants and their derived drugs, I am introducing this review with a purpose to globally popularize the Indian herbal medicines as immunomodulators.

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“…A rasayan may be defined as smooth prostressor, which reduces reactivity of host defense systems and decreases damaging effects of various stressors due to increased basal level of mediators involved in the stress response. 4,5 Curculigo orchioides (CO) Gaertn. (family Amaryllidaceae) is a well-known herb in traditional Indian system of medicine and has been designated as a Vajikaran Rasayan.…”

Section: Introductionmentioning

confidence: 99%

Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats

et al. 2011

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Sustained hyperglycemia is considered as a major cause of sexual and erectile dysfunction in human population. Curculigo orchioides (CO) is considered as a sexual tonic in Ayurvedic system of medicine with potent antioxidant and adaptogenic properties. The aqueous extract of the herb was evaluated for its effectiveness against streptozotocin-induced hyperglycemic stress and subsequent sexual dysfunction due to hyperglycemia in male rats. Six groups with eight male rats in each group were used for this study and the study was carried out for 28 days. The body and organ weights of the animals were recorded. Behavioral analysis of rats was undertaken to observe the effect on mount, ejaculation and intromission (latencies and frequencies) and hesitation time. Blood glucose and serum testosterone levels were determined 28 days past treatment with CO at 100 and 200 mg kg À1 doses. Glibenclamide and sildenafil citrate were used as positive controls. This deleterious effect of sustained hyperglycemia and associated stress was prominently ameliorated in animals treated with aqueous extract of CO. CO treatment was helpful in ameliorating the damage caused by sustained hyperglycemia evidenced in the principle parameters viz. male sexual behavior, sperm count, penile erection index and seminal fructose content Antioxidant and anabolic activities of the extract under investigation could be a major attribute in preserving the sexual functions in hyperglycemic male rats. The study validates the use of CO in traditional medicine for curing diabetes-induced sexual dysfunction and compromised sexual potency.

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Immunomodulatory Activity of Chlorophytum borivilianum Sant. F

Cited by 63 publications

References 13 publications

Comparative phytochemical analysis andin vivoimmunomodulatory activity of various extracts ofStevia rebaudianaleaves in experimental animal model

Comparative phytochemical analysis andin vivoimmunomodulatory activity of various extracts ofStevia rebaudianaleaves in experimental animal model

Immunomodulators: Role of medicinal plants in immune system

Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats

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