Immunomodulatory activity of Zingiber officinale Roscoe, Salvia officinalis L. and Syzygium aromaticum L. essential oils: evidence for humor- and cell-mediated responses

Carrasco, Fábio Ricardo; Schmidt, Gustavo; Romero, Adriano Lopez; Sartoretto, Juliano L.; Caparroz-Assef, Silvana Martins; Bersani-Amado, Ciomar Aparecida; Cuman, Roberto Kenji Nakamura

doi:10.1211/jpp.61.07.0017

Cited by 86 publications

(34 citation statements)

References 26 publications

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“…The plant was reported for antimicrobial [10, 18–22], nephroprotective [22], anti-inflammatory, and immunomodulatory [23] activities. Traditionally, ginger is reported totreatnausea, vomiting, asthma, cough, palpitation, inflammation, and dyspepsia, loss of appetite, constipation, indigestion, and pain in different parts of the world [24]. Similarly, ginger is used, traditionally, for treating common cold, stomachache, cough, fever, and influenza in Ethiopia [25, 26].…”

Section: Introductionmentioning

confidence: 99%

Synergetic Antimicrobial Effects of Mixtures of Ethiopian Honeys and Ginger Powder Extracts on Standard and Resistant Clinical Bacteria Isolates

Ewnetu

Lemma

Birhane

2014

Evidence-Based Complementary and Alternative Medicine

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Purpose. To evaluate antimicrobial effects of mixtures of Ethiopian honeys and ginger rhizome powder extracts on Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Staphylococcus aureus (MRSA), Escherichia coli (R), and Klebsiella pneumoniae (R). Methods. Agar diffusion and broth assays were performed to determine susceptibility of these standard and resistant clinical bacteria isolates using honey-ginger powder extract mixtures. Results. Honey-ginger powder extract mixtures produced the highest mean inhibition (25.62 mm ± 2.55) compared to the use of honeys (21.63 mm ± 3.30) or ginger extracts (19.23 mm ± 3.42) individually. The ranges of inhibitions produced by honey-ginger extract mixtures on susceptible test organisms (26–30 mm) and resistant strains (range: 19–27 mm) were higher compared to 7–22 mm and 0–14 mm by standard antibiotic discs. Minimum inhibitory concentrations (MIC) of mixture of honeys-ginger extracts were 6.25% (0.625 v/mL) on the susceptible bacteria compared to 75% for resistant clinical isolates. Minimum bactericidal concentration (MBC) of honey-ginger extracts was 12.5% (0.125 g/mL) for all the test organisms. Conclusion. The result of this study showed that honey-ginger powder extract mixtures have the potential to serve as cheap source of antibacterial agents especially for the drug resistant bacteria strains.

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Section: Introductionmentioning

confidence: 99%

Synergetic Antimicrobial Effects of Mixtures of Ethiopian Honeys and Ginger Powder Extracts on Standard and Resistant Clinical Bacteria Isolates

Ewnetu

Lemma

Birhane

2014

Evidence-Based Complementary and Alternative Medicine

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“…Carum copticum (bishop's weed) seeds EO compounds: α-pinene and carvacrol [34] Eucalyptus globulus (eucalyptus) [23,24] Eugenia caryophyllata [35] Massoia aromatica bark EO and massoialactone [36,37] Melaleuca viridiflora (niaouli) [38] orange EO, and its components: Limonene, linalool, and citral [39] Panax ginseng (ginseng) [40] Salvia officinalis (sage) [41] Syzygium aromaticum (clove) [41] Zanthoxylum rhoifolium [42] Zingiber officinale (ginger) [41] Dietary Supplementation for Livestock and Fish a blend of thyme (Thymus vulgaris), peppermint (Mentha piperita), and eucalyptus (Eucalyptus globulus) [43] a blend of thymol and carvacrol [44] a blend of thymol and cinnamaldehyde [45][46][47][48] Allium sativum (garlic) [49] Ducrosia anethifolia [50] Eucalyptus globulus (eucalyptus) [51] Juniperus communis (juniper) [49] Ocimum americanum (American basil) [52] Origanum onites [53] Origanum vulgare (oregano) [54] Satureja hortensis (savoury) [55] Thymus vulgaris (thyme) [56] Human Studies a blend of lavender (Lavandula angustifolia), cypress (Cupressus sempervirens), and sweet marjoram (Origanum majorana) [57] a blend of orange sweet (Citrus sinensis), true lavender, and marjoram sweet (Origanum majorana) [58] a blend of sweet orange (Citrus aurantium), lavender (Lavandula angustifolia), and sandalwood (Santalum album) [59] Chamaecyparis obtusa (hinoki cypress) [60] Citrus fragrance (lemon oil+orange oil+bergamot oil+cis-4-hexenol) [61] ginger EO [62] grapefruit, fennel, pepper, lavender, patchouli, and rose [63] La...…”

Section: In Vitro Investigationsmentioning

confidence: 99%

“…The immunomodulatory effects of clove (Syzygium aromaticum), ginger (Zingiber officinale), and sage (Salvia officinalis) EOs were assessed by Carrasco et al in healthy and cyclophosphamide-immunosuppressed mice administered the EOs orally, by determining the antibody titers with hemagglutination (humoral immune response) after immunization with sheep red blood cells (SRBCs), and measuring paw volume after challenging with a second SRBC suspension (delayed-type hypersensitivity, cellular immune response) [41]. Clove EO increased the leukocyte number, augmented the delayed-type hypersensitivity (DTH) response, while in immunosuppressed mice, it restored cellular and humoral immune responses.…”

Section: In Vivo Pre-clinical Studiesmentioning

confidence: 99%

“…Ginger EO was also able to improve the humoral immune response in immunosuppressed mice. Sage EO demonstrated no immunomodulatory activity [41]. Components of Carum copticum seeds EO administered orally to mice were tested by measuring primary (on day 14) and secondary (on day 21) antibody levels following immunization with SRBCs, by assessing foot-pad reaction after an injection of SRBCs in the paw on day 22 (DTH), and by examining phagocytosis of heat-killed Candida albicans cells by peritoneal macrophages on day 25.…”

Section: In Vivo Pre-clinical Studiesmentioning

confidence: 99%

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Much More Than a Pleasant Scent: A Review on Essential Oils Supporting the Immune System

et al. 2019

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The augmenting acceptance and application of herbal medicine in prevention and treatment of diseases also involve the use of plant essential oils (EOs) through different routes of administration (aromatherapy). Scientific data supporting the efficacy of certain herbal products are continuously growing; however, the cumulative evidence is not always sufficient. The anti-inflammatory properties of EOs have been investigated more extensively and also reviewed in different settings, but so far, our review is the first to summarize the immune-supporting properties of EOs. Our aim here is to synthesize the currently available data on the immune function enhancing effects of EOs. An online search was conducted in the PubMed database, which was terminated at the end of July 2019. Other articles were found in the reference lists of the preselected papers. Studies that applied whole EOs with known components, or single EO constituents under in vitro or in vivo laboratory conditions, or in human studies, and de facto measured parameters related to immune function as outcome measures were included. Two specific fields, EO dietary supplementation for livestock and fish, and forest bathing are also explored. Some EOs, particularly eucalyptus and ginger, seem to have immune function enhancing properties in multiple studies.

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“…Salvinorin A, extracted from Salvia spp. [550–552] showed immunomodulatory properties. Other Lamiaceae with antiinfective compounds include Satureja hortensis [553].…”

Section: Two Decades Of Traditional Medicine Research In Northern mentioning

confidence: 99%

The Globalization of Traditional Medicine in Northern Peru: From Shamanism to Molecules

Bussmann

2013

Evidence-Based Complementary and Alternative Medicine

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Northern Peru represents the center of the Andean “health axis,” with roots going back to traditional practices of Cupisnique culture (1000 BC). For more than a decade of research, semistructured interviews were conducted with healers, collectors, and sellers of medicinal plants. In addition, bioassays were carried out to evaluate the efficacy and toxicity of plants found. Most of the 510 species encountered were native to Peru (83%). Fifty percent of the plants used in colonial times have disappeared from the pharmacopoeia. Market vendors specialized either on common and exotic plants, plants for common ailments, and plants only used by healers or on plants with magical purposes. Over 974 preparations with up to 29 different ingredients were used to treat 164 health conditions. Almost 65% of the medicinal plants were applied in these mixtures. Antibacterial activity was confirmed in most plants used for infections. Twenty-four percent of the aqueous extracts and 76% of the ethanolic extracts showed toxicity. Traditional preparation methods take this into account when choosing the appropriate solvent for the preparation of a remedy. The increasing demand for medicinal species did not increase the cultivation of medicinal plants. Most species are wild collected, causing doubts about the sustainability of trade.

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Immunomodulatory activity of Zingiber officinale Roscoe, Salvia officinalis L. and Syzygium aromaticum L. essential oils: evidence for humor- and cell-mediated responses

Abstract: Our findings establish that the immunostimulatory activity found in mice treated with clove essential oil is due to improvement in humor- and cell-mediated immune response mechanisms.

Cited by 86 publications

References 26 publications

Synergetic Antimicrobial Effects of Mixtures of Ethiopian Honeys and Ginger Powder Extracts on Standard and Resistant Clinical Bacteria Isolates

Synergetic Antimicrobial Effects of Mixtures of Ethiopian Honeys and Ginger Powder Extracts on Standard and Resistant Clinical Bacteria Isolates

Much More Than a Pleasant Scent: A Review on Essential Oils Supporting the Immune System

The Globalization of Traditional Medicine in Northern Peru: From Shamanism to Molecules

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