Immunomodulatory activity of methanolic extracts of Pongamia glabra Vent. seeds and bark in cyclophosphamide induced mice

Heroor, Sanjeev; Beknal, Arunkumar; Mahurkar, Nitin

doi:10.5530/rjps.2012.1.10

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…This increased therapeutic result is possible because of the presence of synergistically working phytochemicals with the co-administration of similar antidiabetic effects-producing herbs. When working with a composite extract, Heroor et al (2013) and Rekha (2010) found better hypoglycemic results than the individual extracts, which is consistent with our research results.…”

Section: Physiological Parameterssupporting

confidence: 91%

“…However, the combined extract may lower the glucose absorption rate from the intestinal lumen through delayed carbohydrate digestion by inhibiting maltose, an α-glucosidase enzyme, and reduce postprandial blood glucose levels in a short term (Rekha, 2010). Heroor et al (2013) and Rekha (2010) similarly reported a significant decrease in post-ingestion glycemia after combined extract treatment.…”

Section: Gross and Histo-architectural Changes Of The Pancreasmentioning

confidence: 95%

“…Polyherbal formulations enhance medicinal efficacy while lowering single herb concentrations, hence minimizing adverse effects and herbal overdosage. Therefore, long-term treatment of diabetes mellitus through combined herbal therapy is feasible as their reported antidiabetogenic activity is on par with other synthetic hypoglycemic agents (Heroor et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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In vivo histopathologic and histomorphometric evaluation of the antidiabetic potential of Syzygium cumini and Ficus racemosa herb

Amin

2023

Acta fytotechn zootechn

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Licensed under a Creative Commons Attribution 4.0 International License Seeds of Syzygium cumini and fruits of Ficus racemosa individually are reputed to have hypoglycemic properties, but their consorted efficacy is yet to reveal, which may produce an improved antidiabetic effect because of synergistic phytochemical interaction. Hence, the antidiabetic potency of a combined extract of S. cumini seeds and F. racemosa fruits was investigated using glibenclamide as a reference drug in terms of physiologic, hematologic, histopathologic, and histomorphometric restoration. For a 30-day experiment, seventy-two Swiss albino mice were grouped as normal control, diabetic control (alloxan @ 150 mg.kg -1 b.wt), glibenclamide (@ 600 μg.kg -1 b.wt), and combined herbal extract (ethanolic extracts of S. cumini seeds @ 500 mg.kg -1 b.wt and F. racemosa fruits @ 200 mg.kg -1 b.wt). Diabetic control mice presented hyperglycemia and significantly lower body and pancreas weights. When the combined herbal extract was administered, the diabetic animals' body and organ weights increased, and glycemic levels fell; the exhibited hypoglycemic effect was better than the reported individual treatment and statistically similar (p <0.05) to the reference drug. Postprandial hypoglycemia found in the glucose tolerance test also indicates improved glucose usage ability of the combined extract by the cells and tissues. Diabetes-induced changes in the pancreas such as fibrosis, vascular congestion, decreased number, and diameter of the islets, were restored to near-normal after combined herbal extract and glibenclamide administration. Collectively, the combined herbal extract derived from S. cumini seeds and F. racemosa fruits was better than their individual dose and was nearly as effective as a standard hypoglycemic drug.

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Section: Physiological Parameterssupporting

confidence: 91%

Section: Gross and Histo-architectural Changes Of The Pancreasmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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In vivo histopathologic and histomorphometric evaluation of the antidiabetic potential of Syzygium cumini and Ficus racemosa herb

Amin

2023

Acta fytotechn zootechn

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“…Tannins are also known to possess immunostimulating activity (Heroor et al, 2012). The well-known ayurvedic formulation, Triphala contains Terminalia chebula, Terminalia belerica and Emblica officinalis, which are rich in tannins have been reported to have immunostimulating activity (Srikumar, 2005) …”

Section: Discussionmentioning

confidence: 99%

The Immunostimulatory and Antimicrobial Property of two Herbal Decoctions used in the Management of Hiv/Aids in Ghana

Koffuor

Dickson

Gbedema

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: HIV/AIDS is a pandemic retarding economic growth and destroying human capital globally. This study therefore investigated the perceived efficacy of Betula alba (BA) and Sutherlandia frutescens (SF) decoctions used in the management of HIV/AIDS in Ghana. Materials and Methods: A study on the records of HIV/AIDS patients attending Habibi Herbal Clinic, Kumasi, Ghana, was conducted to obtain information on the initial viral load presented during their maiden visit and results after treatment with the herbal decoctions. The decoctions were assessed for immunostimulatory property in cyclophosphamide-induced immunosuppressed ICR mice. Total white blood cell count, as well as lymphocyte and neutrophil counts were determined and their effects compared with Levamisole. The decoctions were also screened for antimicrobial activity by the micro dilution method. Results: The two herbal decoctions used significantly reduced (P ≤ 0.001) the patients' viral loads (47.42 ± 17.28 % to 13.69 ± 12.42 %; n=16). BA (1, 2, and 4 mg/kg) and SF (0.4, 0.8, and 1.6 mg/kg) caused significant increment (P ≤ 0.001) in total WBC and lymphocyte count in mice comparable to that produced by 2.5 mg/kg Levamisole. The decoctions also exhibited antimicrobial activity against gram negative and gram positive bacteria as well as Candida albicans (MIC 0.607 to 3.062 mg/ml). Phytochemicals present in both plants include saponins, terpenoids and coumarins. Conclusion:The Betula alba and Sutherlandia frutescens decoctions have interesting immunostimulatory and antimicrobial properties and hence could be useful in the management of HIV/AIDS and associated opportunistic infections.

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“…karanjin, pongapin, kanjone, pongamol, and pongaglabrone, along with a number of simple flavonoids and lipid like arachidonic acid (Bandivdekar et al, 2002). It used as bacteriocidal activity against V. cholerae and E. coli, as well an anti-inflammatory, anti-nociceptive (reduction in sensitivity to painful stimuli) and antipyretic (reduction in fever) properties (Chopade et al, 2008;Herror et al, 2012;Krishnan et al, 2013). (Figure 3) belonging to family (Sunila et al, 2004).…”

mentioning

confidence: 99%

Assessment of wound healing potential of Momordica charantia, Pongamia glabra and their combination with Piper nigrum on anemic albino rats using excision wound model

Shukla¹,

Kashaw²

2018

Asian J Pharm Pharmacol

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Wound infection is one of the most common diseases in developing countries because of poor hygienic conditions (Kumar et al., 2006). Wounds are the physical injuries that result in an opening or breaking of the skin and appropriate method for healing of wounds is essential for the restoration of disrupted anatomical continuity and disturbed functional status of the skin.Wound healing process holds several steps which involve coagulation, inflammation, formation of granulation tissue, matrix formation, remodeling of connective tissue, collagenization and aquisation of wound strength (Enoch et al., 2005; Guo et al., 2010). Momordica charantia Cucurbitaceae belong to family (Jayasooriya et al., 2000). Fruit having ovoid, ellipsoid, or spindle shaped, usually ridged or warty, dehiscent irregularly as a 3 valve fleshy capsule or indehiscent (Figure 1: Fruit, leaves and seeds of). The fruit has a distinct warty M. Charantia looking exterior and an oblong shape. It is hollow in cross section, with a relatively thin layer of flesh surrounding a central seed cavity filled with large flat seeds and pith. M. Charantia consist of the following chemical constituents those are Alkaloids, charantin

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Immunomodulatory activity of methanolic extracts of Pongamia glabra Vent. seeds and bark in cyclophosphamide induced mice

Cited by 6 publications

References 8 publications

In vivo histopathologic and histomorphometric evaluation of the antidiabetic potential of Syzygium cumini and Ficus racemosa herb

In vivo histopathologic and histomorphometric evaluation of the antidiabetic potential of Syzygium cumini and Ficus racemosa herb

The Immunostimulatory and Antimicrobial Property of two Herbal Decoctions used in the Management of Hiv/Aids in Ghana

Assessment of wound healing potential of Momordica charantia, Pongamia glabra and their combination with Piper nigrum on anemic albino rats using excision wound model

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