Immunomodulatory and anti-inflammatory activity of Picrorhiza scrophulariiflora

Smit, H. Friso; Kroes, B. H.; Berg, A. J. J. van den; Wal, D. van der; Worm, Edwin van den; Beukelman, C.J.; Dijk, Hans van; Labadie, R. P.

doi:10.1016/s0378-8741(00)00268-3

Cited by 70 publications

(52 citation statements)

References 10 publications

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“…Different components have been described in P. scrophulariiflora extracted by different organic solvents. The presence of apocynin was determined by HPLC in light petroleum, diethyl ether, and ethyl acetate extracts, while androsin, its O-b-D-glucoside, and picroside II were found in diethyl ether, ethyl acetate, and methanol extracts (Smit et al 2000). In the present study, compounds with small molecular mass picroside I (MW 492 kDa) and picroside II (MW 512 kDa) were identified in the ethanol extracts of P. scrophulariiflora.…”

Section: Discussionmentioning

confidence: 45%

“…This was accompanied by an improvement in renal inflammation, including decreased macrophage influx and downregulated expression of CCL2 and TGFB1. Further support for the anti-inflammatory effects of EPS comes from a study showing that organic extracts of P. scrophulariiflora inhibit non-specific and specific immune responses in vitro and improve carrageenan-induced paw edema in vivo (Smit et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…P. kurrooa grows on the western slopes of the Himalayas in India and P. scrophulariiflora is found in Tibet and China. Picrorhiza is almost insoluble in water but soluble in organic solvents (Luper 1998, Smit et al 2000. Although many components of Picrorhiza have not been identified, evidence has shown that organic solvent extracts of Picrorhiza, such as picroside I, II, and kutkoside, have antioxidant activity similar to that of superoxide dismutase (Chander et al 1992).…”

Section: Introductionmentioning

confidence: 99%

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Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action

He¹,

Liang²,

Hou³

et al. 2008

Journal of Endocrinology

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There is evidence that inflammatory processes are involved in the development and/or progression of diabetic nephropathy. However, effective treatment for inflammation in the kidneys of diabetic is practically unknown. The rhizomes of Picrorhiza scrophulariiflora (PS) are a traditional medication long used to treat inflammatory diseases. The aim of the present study was to test the hypothesis that the ethanol extract of PS (EPS) may reduce inflammation in patients with diabetic kidneys. Streptozotocin-induced diabetic rats were randomly assigned to two groups treated with a gavage of either EPS or vehicle. A group of non-diabetic control rats was treated concurrently. Compared with vehicle-treated diabetic rats, EPS-treated animals displayed a significant decrease in renal macrophage infiltration and overexpression of chemokine (C-C motif) ligand 2 (CCL2) and TGFB1. This was associated with attenuation of the structural and functional abnormalities of early diabetic nephropathy, such as glomerular hypertrophy, mesangial expansion, and albuminuria. Administration of EPS significantly reduced NADPH oxidase-dependent superoxide generation and decreased expression of malondialdehyde and advanced oxidation protein products in diabetic kidney. These data suggest that EPS might improve diabetic nephropathy, probably through inhibition of redox-sensitive inflammation.

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action

He¹,

Liang²,

Hou³

et al. 2008

Journal of Endocrinology

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“…12 Picroside II is one of the main active constituents of the extracts of picrorrhiza scrophulariiflora pennell and was shown to possess a wide range of pharmacological effects. 13,14 However, it was not known about the role of Picroside II in ischemia-induced renal fibrosis. Therefore, the aim of this study was to demonstrate whether Picroside II could have a beneficial effect in prevent the development of renal fibrosis after I/R injury and its possible mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Picroside II decreases the development of fibrosis induced by ischemia/reperfusion injury in rats

Wang¹,

Liu²,

Chen³

et al. 2014

Renal Failure

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In kidney transplantation, renal ischemia and reperfusion injury was one of the leading factors to the development of renal fibrosis, which was the main cause of graft loss. The fibrogenic changes were associated with the long term inflammation elicited by ischemia and reperfusion injury. In the present study, we investigated the role of the Picroside II, the main active constituents of the extract of picrorrhiza scrophulariiflora roots, in attenuating renal fibrosis in a renal ischemia and reperfusion injury model. We induced ischemia and reperfusion injury in kidneys treated with or without Picroside II. We observed that inflammation and tissue fibrosis were increased in ischemia and reperfusion injury group compared to Picroside II group, however, these changes were significantly decreased by the treatment with Picroside II. We concluded that Picroside II can protect the ischemic kidney against renal fibrosis and its mechanism may be through the inhibition of the long term inflammation.

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“…Propriedades imunomoduladoras de várias plantas tem sido avaliadas (SaiRam et al, 1997;Borchers et al, 2000;Davis e Kuttan, 2000;Smit et al, 2000;Ross et al, 2001;Bin-Hafeez et al, 2003), visto que o sistema imune está envolvido na etiologia e nos mecanismos fisiopatológicos de muitas doenças (Lin et al, 2005).…”

Section: A Família Amaranthaceae E O Gênero Alternantheraunclassified

Avaliação da atividade imunomoduladora de 'Alternanthera tenella' Colla e investigação de ações do extrato aquoso em modelo de artrite experimental

Biella¹

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Immunomodulatory and anti-inflammatory activity of Picrorhiza scrophulariiflora

Cited by 70 publications

References 10 publications

Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action

Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action

Picroside II decreases the development of fibrosis induced by ischemia/reperfusion injury in rats

Avaliação da atividade imunomoduladora de 'Alternanthera tenella' Colla e investigação de ações do extrato aquoso em modelo de artrite experimental

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