Picroside II decreases the development of fibrosis induced by ischemia/reperfusion injury in rats

Abstract

In kidney transplantation, renal ischemia and reperfusion injury was one of the leading factors to the development of renal fibrosis, which was the main cause of graft loss. The fibrogenic changes were associated with the long term inflammation elicited by ischemia and reperfusion injury. In the present study, we investigated the role of the Picroside II, the main active constituents of the extract of picrorrhiza scrophulariiflora roots, in attenuating renal fibrosis in a renal ischemia and reperfusion injury model. We induced ischemia and reperfusion injury in kidneys treated with or without Picroside II. We observed that inflammation and tissue fibrosis were increased in ischemia and reperfusion injury group compared to Picroside II group, however, these changes were significantly decreased by the treatment with Picroside II. We concluded that Picroside II can protect the ischemic kidney against renal fibrosis and its mechanism may be through the inhibition of the long term inflammation.

Network Pharmacology-Integrated Molecular Docking Reveals the Expected Anticancer Mechanism of Picrorhizae Rhizoma Extract

“…hepatoprotective and choleretic effects [3,4], protective effects against neuronal cell injury [5], protective effects against myocardial apoptosis [6,7], and immunomodulatory effects.…”

Picroside II protects myocardium from ischemia/reperfusion-induced injury through inhibition of the inflammatory response

“…Furthermore, it has been reported that picroside II is capable of protecting the heart or kidney from I/R-induced injury by inhibition of the inflammatory response (15,16). These studies suggested that picroside II has an anti-inflammation property.…”

“…In the rat model of middle cerebral artery occlusion and reperfusion, pretreatment with picroside II could significantly improve the neurobehavioral function and inhibit neurocyte apoptosis, which was correlated with a decrease of inflammatory factor production by inhibition of the TLR-4/NF-κB signaling pathway (15). In addition, the study by Wang et al (16) demonstrated that picroside II was able to decrease I/R-induced renal fibrosis in rats by inhibition of long-term inflammation. Recently, it has been reported that picroside II has a protective effect on myocardial I/R injury in rats (17).…”

Synthesis and Primary Biological Evaluation of Triazole‐Modified Picroside II Compounds

“…Picroside as an active ingredient of Picrorhiza scrophulariiflora, is iridoid glycoside, which has many pharmacological activities such as liver‐protective and choleretic effect, anti‐tumor and anti‐diabetics and so on [1] . The Picroside II (PII, Figure 1) as the main component has multiple pharmacological effects, including anti‐apoptosis, [2] anti‐inflammatory, [3] anti‐cancer, [4] anti‐oxidation, [5] anti‐virus, [6] neuroprotection, [7,8] myocardial protection, [9,10] kidney protection, [11] liver protection, [12] cerebral ischemic injury protection, [13] anti‐bone resorption [14] and so on.…”