Immunomodulatory and antimetastatic action of propolis and related polyphenolic compounds

Oršolić, Nada; Knežević, Anica Horvat; Šver, Lidija; Terzić, Svjetlana; Basić, Ivan

doi:10.1016/j.jep.2004.06.006

Cited by 181 publications

(123 citation statements)

References 30 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…They also noticed that propolis and some isolated polyphenolic compounds decreased the number of tumour nodules in the lung, and the antimetastatic effectiveness of propolis was higher than that achieved by its constituents. [7,16,17] The treatment of rats with Brazilian EEP increased the cytotoxic activity of natural killer cells against murine lymphoma. [18] Experiments by our group were designed to evaluate the effects of EEP in melanoma-bearing mice submitted to stress.…”

Section: Propolis Extracts From Different Geographic Regionsmentioning

confidence: 99%

Cytotoxic constituents of propolis inducing anticancer effects: a review

Watanabe

Amarante

Conti

et al. 2011

Journal of Pharmacy and Pharmacology

191

133

View full text Add to dashboard Cite

Objectives Propolis is a honeybee product used extensively in traditional medicine for its antioxidant, anti-inflammatory, immunomodulatory and anticancer effects. Propolis exhibits a broad spectrum of biological activities because it is a complex mixture of natural substances. In this review, the antitumour effects of propolis extracts and its constituents (e.g. flavonoids, terpenes and caffeic acid phenethyl ester) are discussed. Key findings The effect of propolis on experimental carcinogenesis is discussed, as well as its possible mechanisms of action against tumours, involving apoptosis, cell cycle arrest and interference on metabolic pathways. Propolis seems to be efficient against different tumour cells both in vitro and in vivo, which suggests its potential in the development of new anticancer drugs. Summary Propolis extracts may be important economically and would allow a relatively inexpensive cancer treatment. Preclinical investigations are needed to further elucidate the benefits of propolis and its antitumour properties.

show abstract

Section: Propolis Extracts From Different Geographic Regionsmentioning

confidence: 99%

Cytotoxic constituents of propolis inducing anticancer effects: a review

Watanabe

Amarante

Conti

et al. 2011

Journal of Pharmacy and Pharmacology

191

133

View full text Add to dashboard Cite

show abstract

“…This enhanced capacity is related to the optimal configuration of two pharmacophores within the molecule (Heijnen et al, 2002). Furthermore, various in vitro studies have shown that QUER possesses a wide range of pharmacologic and health promoting properties including antimicrobial (Cushnie andLamb, 2005, Sen et al, 2007), anti-inflammatory (Orsolic et al, 2004, Read, 1995 and anti-tumorogenic/anti-proliferative (Gulati et al, 2006, Kuo, 1996 More in vivo studies regarding QUER supplementation have been performed but lack of positive effects was reported (Conquer et al, 1998, Wilms et al, 2005. This however could be explained by the fact that the latter studies involved study of healthy volunteers and not subjects under Nevertheless, there are reports of other groups in the mouse model where a protective effect of topical formulations containing QUER against UVB-induced oxidative stress in hairless mice was reported (Casagrande et al, 2006).…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Anti-ageing and rejuvenating effects of quercetin

Chondrogianni

Kapeta

Chinou

et al. 2010

Experimental Gerontology

184

View full text Add to dashboard Cite

Homeostasis is a key feature of the cellular lifespan. Its maintenance influences the rate of ageing and it is determined by several factors, including efficient proteolysis. The proteasome is the major cellular proteolytic machinery responsible for the degradation of both normal and damaged proteins. Alterations of proteasome function have been recorded in various biological phenomena including ageing and replicative senescence. Proteasome activities and function are decreased upon replicative senescence, whereas proteasome activation confers enhanced survival against oxidative stress, lifespan extension and maintenance of the young morphology for longer in human primary fibroblasts. Several natural compounds possess anti-ageing/anti-oxidant properties. In this study, we have identified quercetin (QUER) and its derivative, namely quercetin caprylate (QU-CAP) as a proteasome activator with antioxidant properties that consequently influence cellular lifespan, survival and viability of HFL-1 primary human fibroblasts. Moreover, when these compounds are supplemented to already senescent fibroblasts, a rejuvenating effect is observed. Finally, we show that these compounds promote physiological alterations when applied to cells (i.e. whitening effect). In summary, these data demonstrate the existence of naturally occurring anti-ageing products that can be effectively used through topical application.

show abstract

“…Sendo assim, seria um novo agente no tratamento da asma. Orsolic et al (2004) demonstraram que derivados hidrossolúveis de própolis, ácido caféico, éster feniletil do ácido caféico e quercetina poderiam ser extremamente úteis no controle do crescimento tumoral em modelos experimentais. Nos últimos anos muitos estudos tem demonstrado a atividade da própolis no sistema imunológico (ativando macrófagos, aumentando a atividade lítica contra células tumorais, estimulando anticorpos, etc) como apresentado numa extensa revisão realizada por Sforcin (2000), todavia, cita que os mecanismos envolvidos na quimioprevenção ainda não são completamente conhecidos.…”

Section: Imunomodulatóriaunclassified

Própolis: atualizações sobre a química e a farmacologia

Lustosa¹,

Galindo²,

Nunes³

et al. 2008

Rev. bras. farmacogn.

114

View full text Add to dashboard Cite

RESUMO:Própolis é uma mistura complexa, formada por material resinoso e balsâmico. Sua composição química é complexa e variada, estando relacionada com a fl ora de cada região visitada pelas abelhas e com o período de coleta da resina. Inclui fl avonóides, ácidos aromáticos, terpenóides e fenilpropanóides, ácidos graxos e vários outros compostos. A própolis tem sido objeto de intensos estudos farmacológicos e químicos nos últimos 30 anos. Em várias partes do mundo é indicada para melhorar a saúde e prevenir doenças. Atualmente, é disponível em várias formas farmacêuticas como cápsulas, extratos, enxaguatório bucal, na forma de pó, entre outras. Ainda são necessários estudos correlacionando a composição química com a atividade biológica, defi nindo cada tipo de própolis com a sua aplicação terapêutica. É uma tarefa imprescindível para um mercado cada vez maior e exigente em todo o mundo.Unitermos: Própolis, constituintes químicos, atividade biológica.ABSTRACT: "Propolis: updates on chemistry and pharmacology". Propolis (bee glue) is a complex mixture, formed by resinous and balsamic material. Its chemical composition is variable and complex, being related with the fl ora of each region visited by the bees and with the period of resins collection. Flavonoids, aromatic acids, terpenoids and phenylpropanoids, fatty acids, and other compounds are found in propolis. In the last 30 years, propolis has become subject of intense pharmacological and chemical studies. In different parts of the world it is indicated to improve health and prevent illnesses. Currently, it is available in some pharmaceutical forms as capsules, extracts, mouthrinses, powder form, among others. Indeed, studies correlating the chemical composition with the biological activity are necessary, defi ning each type of propolis with its therapeutic application. It is an essential task for a market ever bigger and demanding in the whole word.

show abstract

Immunomodulatory and antimetastatic action of propolis and related polyphenolic compounds

Cited by 181 publications

References 30 publications

Cytotoxic constituents of propolis inducing anticancer effects: a review

Cytotoxic constituents of propolis inducing anticancer effects: a review

Anti-ageing and rejuvenating effects of quercetin

Própolis: atualizações sobre a química e a farmacologia

Contact Info

Product

Resources

About