Immunomodulatory and toxicological evaluation of the fruit seeds from Platonia insignis, a native species from Brazilian Amazon Rainforest

Lustosa, Ana Karina Marques Fortes; Arcanjo, Daniel Dias Rufino; Ribeiro, Rayra G.; Rodrigues, Klinger Antônio da França; Passos, Flávia Franceli B.; Piauilino, Celyane Alves; Silva-Filho, José Couras; Araújo, Bruno Quirino; Lima-Neto, José S.; Costa-Júnior, Joaquim Soares da; Carvalho, Fernando Aécio de Amorim; Citó, Antônia Maria das Graças Lopes

doi:10.1016/j.bjp.2015.05.014

Cited by 34 publications

(23 citation statements)

References 31 publications

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“…Cytotoxicity, MTT and hemolytic activity assays, performed with EHPi, FAcOEt and MB showed low cytotoxicity for macrophages, essential cells in the defense mechanisms of leishmaniasis, and for sheep erythrocytes, with CH50 being at concentrations well above 800 μg/mL, indicating greater selectivity for the parasite than for mammalian cells. Cytotoxicity assays with the hexanic extract of bacuri fruit seeds showed similar results, with a CH50 of 90.03 µg/mL for murine macrophages, with a confidence interval between 70.72 and 114.6 µg/mL and 3% hemolysis in human erythrocytes at the concentration of 400 µg/mL [ 13 ], reaffirming its use as safe.…”

Section: Discussionmentioning

confidence: 81%

“…It is widely used in the treatment of skin diseases, spider and snake bites, rheumatic arthritis and is also used as a cicatrizing agent [ 9 ]. Trials performed with the seeds of the fruits have demonstrated wound-healing and anti-inflammatory activities [ 10 ], anticonvulsant [ 11 ], antileishmania [ 12 ], immunomodulatory [ 13 ], antimicrobial and anti-inflammatory activities [ 10 ]. Furthermore, the fruit pulp has an antioxidant activity [ 14 ], and the fruit peels have been used for the treatment of eczema and arthritis [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Biflavones from Platonia insignis Mart. Flowers Promote In Vitro Antileishmanial and Immunomodulatory Effects against Internalized Amastigote Forms of Leishmania amazonensis

et al. 2021

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Leishmaniasis is an infectious disease that affects millions of people worldwide, making the search essential for more accessible treatments. The species Platonia insignis Mart. (Clusiaceae) has been extensively studied and has gained prominence for its pharmacological potential. The objective of this work was to evaluate the antileishmania activity, cytotoxic effect and activation patterns of macrophages of hydroalcoholic extract (EHPi), ethyl acetate fractions (FAcOEt) and morelloflavone/volkensiflavone mixture (MB) from P. insignis flowers. EHPi, FAcOEt and MB demonstrated concentration-dependent antileishmania activity, with inhibition of parasite growth in all analyzed concentrations. EHPi exhibited maximum effect at 800 μg/mL, while FAcOEt and MB reduced the growth of the parasite by 94.62% at 800 μg/mL. EHPi, FAcOEt and MB showed low cytotoxic effects for macrophages at 81.78, 159.67 and 134.28 μg/mL, respectively. EHPi (11.25 µg/mL), FAcOEt (11.25 and 22.5 µg/mL) and MB (22.5 µg/mL) characterized the increase in lysosomal activity, suggesting a possible modulating effect. These findings open for the application of flowers from a P. insignis flowers and biflavones mixture thereof in the promising treatment of leishmaniasis.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Biflavones from Platonia insignis Mart. Flowers Promote In Vitro Antileishmanial and Immunomodulatory Effects against Internalized Amastigote Forms of Leishmania amazonensis

et al. 2021

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“…Estudos de toxicidade de doses repetidas aconselham a observação dos animais por, no mínimo, 2 semanas, caracterizando o perfil toxicológico da substância pela administração repetida, avaliando os quadros de: mortalidade, sinais clínicos (incluindo parâmetros comportamentais); variações no peso corporal e no consumo de ração e água, patologia clínica (hematologia, bioquímica); duração e reversibilidade da toxicidade . Desse modo, a baixa toxicidade do EH-Pi, no tratamento agudo, pôde ser comparado aos resultados também expressos por Lustosa et al (2016), em relação ao peso dos animais, para o extrato das sementes de P. insignis e por , através de estudos pré-clínicos em ratos, com um composto isolado da P. insignis, a Garcinialiptona FC (GFC), respectivamente. No entanto, por serem agentes xenobióticos, seus efeitos podem não se manifestar de forma imediata o que intensifica as ações tóxicas mediante uso crônico, como por exemplo, comprometimento hepático e renal, alterações hematológicas,…”

Section: Resultsunclassified

CARACTERIZAÇÃO CENTESIMAL E MINERAL DO XILOGLUCANO EXTRAÍDO DA SEMENTE DE Hymenaea Courbaril L. DO ESTADO DO CEARÁ

Vergara¹,

Reis²,

Matos³

et al. 2020

Propostas, Recursos E Resultados Nas Ciências Da Saúde 7

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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“…As benzofenonas poliprenilada são metabólitos secundários das plantas que despertam crescente interesse, principalmente devido às propriedades farmacológicas. Estudos in vitro anteriores mostraram que o composto garcinielliptone FC, substância isolada da semente do bacuri possui efeito antioxidante, vasorrelaxante e antiparasitário (6) .…”

Section: Introductionunclassified

Pharmacological actions of bacuri butter (Platonia insignis Mart.): an integrative review

Ribeiro¹,

Figueiredo²,

Carvalho³

et al. 2021

Rev Rene

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Objective: to identify the pharmacological activities of bacuri butter (Platonia insignis Mart.). Methods: an integrative review, carried out in the databases of Latin American and Caribbean Literature in Health Sciences, Cumulative Index to Nursing and Allied Health Literature, EMBASE, MEDLINE/PubMed, Web of Science, Cochrane Library and SCOPUS, without the time and language restriction. The selection consisted of 13 pre-clinical trials. The information assessment descriptively took place, comparing with the pertinent findings. Results: it was observed that 50.0% of the publications were indexed in MEDLINE/PubMed, most publications were from England (61.5%), followed by Brazil and the United States, both with 13.3%. It is noteworthy that 100.0% of the articles were pre-clinical trials; pharmacological activities for antioxidants (38.4%) and antileishmanicides (30.7%). It was found that 38.4% of the trials presented toxicity tests. Conclusion: bacuri butter (Platonia insignis Mart.) Showed pharmacological activities in pre-clinical trials, such as antioxidants, antileshimaniasis, anticonvulsant and wound healing.

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Immunomodulatory and toxicological evaluation of the fruit seeds from Platonia insignis, a native species from Brazilian Amazon Rainforest

Cited by 34 publications

References 31 publications

Biflavones from Platonia insignis Mart. Flowers Promote In Vitro Antileishmanial and Immunomodulatory Effects against Internalized Amastigote Forms of Leishmania amazonensis

Biflavones from Platonia insignis Mart. Flowers Promote In Vitro Antileishmanial and Immunomodulatory Effects against Internalized Amastigote Forms of Leishmania amazonensis

CARACTERIZAÇÃO CENTESIMAL E MINERAL DO XILOGLUCANO EXTRAÍDO DA SEMENTE DE Hymenaea Courbaril L. DO ESTADO DO CEARÁ

Pharmacological actions of bacuri butter (Platonia insignis Mart.): an integrative review

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