Immunomodulatory basis of antioxidant therapy and its future prospects: an appraisal

Ajith, Y.; Dimri, Umesh; Dixit, S. K.; Singh, Shanker K.; Gopalakrishnan, A.; Madhesh, E.; Rajesh, J. B.; Sangeetha, Shubha

doi:10.1007/s10787-017-0393-5

Cited by 23 publications

(14 citation statements)

References 105 publications

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“…The present study explains that the antioxidant therapy can curb this pathological mechanism by modulating oxidative metabolisms preventing exhaustive damage to â cells. Similarly, the modulation of host immune mechanisms by the antioxidant N-acetylcysteine in Th1 cytokine dominant disease conditions was previously suggested by Ajith et al (2017). Also, the human form of IDDM is usually considered as a Th1 dominant condition with increased expression of Th1 cytokines (Eizirik et al 2009).…”

Section: Resultsmentioning

confidence: 82%

The Anti-oxidant and the Anti-diabetic Effects of Terminalia chebula and Withania somnifera in Subclinically Diabetic Dogs

Gopinath

Dimri

Ajith

et al. 2021

IJAR

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Background: The present study evaluated the antioxidant as well as the anti-diabetic potential of Terminalia chebula (Haritaki) and Withania somnifera (Ashwagandha) in subclinically diabetic dogs.Methods: A total of thirty subclinically diabetic dogs were divided into five groups of six animals each; Group I (Positive control), Group II (T. chebula extract), Group III (W. somnifera extract), Group IV (T. chebula and W. somnifera extracts at 1:1 ratio) and Group V (N- acetylcysteine). Six apparently healthy dogs were kept as negative control (Group VI) for the study. The animals were evaluated based on diabetic biomarkers (Random blood glucose, fasting blood glucose, glycated hemoglobin, serum fructosamine and serum insulin) and oxidative stress markers (lipid peroxidation, reduced glutathione, superoxide dismutase and catalase activities) on days 0, 15 and 30 of the study.Result: Significant oxidative stress was observed in the subclinically diabetic dogs and the supplementation of N- acetylcysteine, T. chebula and W. somnifera effectively curbed the oxidative impairments and further progression of diabetes. The improvement in oxidative, as well as diabetic biomarkers, was predominant in Group V animals, followed by Group IV, Group II and Group III. It may be concluded that therapeutic modulation of redox mechanisms may aid in the clinical management of subclinical diabetes mellitus, however, the mechanisms involved should be further explored.

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Section: Resultsmentioning

confidence: 82%

The Anti-oxidant and the Anti-diabetic Effects of Terminalia chebula and Withania somnifera in Subclinically Diabetic Dogs

Gopinath

Dimri

Ajith

et al. 2021

IJAR

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“…A clinical challenge is to achieve transplants that integrate advanced functional biomaterials with stem cells and biological regulators (such as antimicrobial, immunomodulatory, and trophic compounds) [ 253 ]. Redox equilibrium can be a key player in modulating these regulators; namely, the antioxidants can play a central role as immunomodulators [ 254 ]. A promising assumption in post-operation could be derived from an augmented bioavailability in the human body of natural products in association with standard pharmaceutical therapy.…”

Section: Discussionmentioning

confidence: 99%

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Marrazzo

O’Leary

2020

Bioengineering

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Although a large panel of natural antioxidants demonstrate a protective effect in preventing cellular oxidative stress, their low bioavailability limits therapeutic activity at the targeted injury site. The importance to deliver drug or cells into oxidative microenvironments can be realized with the development of biocompatible redox-modulating materials. The incorporation of antioxidant compounds within implanted biomaterials should be able to retain the antioxidant activity, while also allowing graft survival and tissue recovery. This review summarizes the recent literature reporting the combined role of natural antioxidants with biomaterials. Our review highlights how such functionalization is a promising strategy in tissue engineering to improve the engraftment and promote tissue healing or regeneration.

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“…infested treatment groups on day 0 and day 28 The current study showed that bubaline pediculosis caused by H. tuberculatus infestation had severe oxidative stress, anaemia, leukocytosis with neutrophilia, eosinophilia and lymphocytopenia. Other ectoparasitic infestations in various domestic animals; ovine pediculosis (Dede et al, 2002), pediculosis in goats (Ajith et al, 2017b), pediculosis in buffaloes (El-Moghazy, 2011), generalized canine demodicosis (Dimri et al, 2008), psoroptic mange infection in sheep (Aktas et al, 2017), sarcoptic mange in domestic goats (De and Dey, 2010), dogs (Behera et al, 2011;Singh and Dimri, 2013) and dairy buffaloes (Dimri et al, 2007) had similar oxidative stress and haematological changes observed in bubaline pediculosis. Growing body of evidence from recent studies promises the potential use of antioxidants for prophylactic and therapeutic management of various infectious diseases.…”

Section: Table1 Mean Lice Count In Different Body Regions Of Sucking Lice (Haematopinus Tuberculatus)mentioning

confidence: 99%

Vitamin C Moderates the Oxidative Stress of Bubaline Pediculosis in Indian Water Buffaloes

Madhesh¹,

Dimri²,

Ajith³

et al. 2020

Int.J.Curr.Microbiol.App.Sci

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Bubaline pediculosis caused by the sucking lice, Haematopinus tuberculatus is a widespread and economically important ectoparasitic infestation of Indian water buffaloes. This lice infestation in buffalo is characterized by anemia, mineral imbalance and loss of performance but its pathobiology is unexplored. The aim of the present study was to investigate the oxidative pathobiology of bubaline pediculosis and its alleviation through the commonly used two antioxidants as an supportive therapy (N-acetyl cysteine and vitamin C). Twenty four Indian dairy buffaloes with severe bubaline pediculosis were allotted to the three groups (Group 1, 2 and 3).Another eight healthy animals free of any clinical anomalies and ectoparasites have been included as healthy controls (Group 4). Sucking lice infested animals (Group 1, 2 and 3) animals were given with single dose of ivermectin therapy @ 200 microgram/kg body weight Subcutaneously; In addition, group 2 and group 3 animals were treated with N-acetyl cysteine @ 12 mg/kg body weight and vitamin C@2g/ per animal po, respectively, once daily for 15 days. Before therapy (Day 0) and post-therapy (Day 28), haematological parameters like total erythrocyte count (TEC),haemoglobin (Hb), total leukocyte count (TLC) and Differential leukocyte count (DLC), and oxidative stress parameters like total antioxidant capacity( TAC), lipid peroxidation (LPO), reduced glutathione (GSH), and superoxide dismutase (SOD) were evaluated on sucking lice infested buffaloes. Sucking lice infestation in Indian water buffaloes has showed severe anaemia, leukocytosis and along with remarkable oxidative stress response. Vitamin C given animals have demonstrated improved recovery from the bubaline pediculosis induced oxidative stress and reached normalcy post-therapeutically. Adjunct therapy of Vitamin C along with subcutaneous ivermectin has alleviated pathological damage in water buffaloes and hastened clinical recovery, while N-acetyl cysteine has been less effective in alleviating the oxidative stress. In future, therapeutic antioxidant studies should address the influence of the oxidative stress response in the host biological system.

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Immunomodulatory basis of antioxidant therapy and its future prospects: an appraisal

Cited by 23 publications

References 105 publications

The Anti-oxidant and the Anti-diabetic Effects of Terminalia chebula and Withania somnifera in Subclinically Diabetic Dogs

The Anti-oxidant and the Anti-diabetic Effects of Terminalia chebula and Withania somnifera in Subclinically Diabetic Dogs

Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering

Vitamin C Moderates the Oxidative Stress of Bubaline Pediculosis in Indian Water Buffaloes

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