Immunomodulatory effect of different extracts from Angiostrongylus cantonensis on airway inflammation in an allergic asthma model

Pascoal, Vanessa Fey; Cunha, Aline Andrea da; Morassutti, Alessandra Loureiro; Antunes, Géssica Luana; Silveira, Keila Abreu da; Silveira, Josiane Silva; Nuñez, Nailê Karine; Souza, Rodrigo Matos de; Graeff-Teixeira, Carlos; Pitrez, Paulo Márcio

doi:10.1007/s00436-020-06884-0

Cited by 3 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, with the eventual decline of helminth populations comes the rise of misdirected immune responses, the allergic reactions. Several studies have demonstrated the immunomodulatory effect of helminth-derived extracts, indicating their possible role in the prevention of allergic diseases ( 14 , 15 ). This phenomenon was first described as the “hygiene hypothesis,” by the epidemiologist, David Strachan ( 16 , 17 ).…”

Section: Current Theories On Allergic Diseasesmentioning

confidence: 99%

Immunologic, genetic, and ecological interplay of factors involved in allergic diseases

Falcon

Caoili

2023

Front. Allergy

View full text Add to dashboard Cite

An allergic or type I hypersensitivity reaction involves a misdirected immune overreaction to innocuous environmental and dietary antigens called allergens. The genetic predisposition to allergic disease, referred to as atopy, can be expressed as a variety of manifestations—e.g., allergic rhinitis, allergic conjunctivitis, atopic dermatitis, allergic asthma, anaphylaxis. Globally, allergic diseases are one the most common types of chronic conditions. Several factors have been identified to contribute to the pathogenesis and progression of the disease, leading to distinctively variable clinical symptoms. The factors which can attenuate or exacerbate allergic reactions can range from genetic heterozygosity, the prominence of various comorbid infections, and other factors such as pollution, climate, and interactions with other organisms and organism-derived products, and the surrounding environment. As a result, the effective prevention and control of allergies remains to be one of the most prominent public health problems. Therefore, to contextualize the current knowledge about allergic reactions, this review paper attempts to synthesize different aspects of an allergic response to describe its significance in the global health scheme. Specifically, the review shall characterize the biomolecular mechanisms of the pathophysiology of the disease based on underlying disease theories and current findings on ecologic interactions and describe prevention and control strategies being utilized. An integrated perspective that considers the underlying genetic, immunologic, and ecologic aspects of the disease would enable the development of more effective and targeted diagnostic tools and therapeutic strategies for the management and control of allergic diseases.

show abstract

Section: Current Theories On Allergic Diseasesmentioning

confidence: 99%

Immunologic, genetic, and ecological interplay of factors involved in allergic diseases

Falcon

Caoili

2023

Front. Allergy

View full text Add to dashboard Cite

show abstract

“…Experimental studies in animal models have shown that infection with helminths such as S. mansoni, H. diminuta, and T. spiralis can ameliorate colitis [98][99][100]. Extracts from nematodes such as Angiostrongylus catonensis, Oesophagostomum dentatum, and the already mentioned T. spiralis modulate the inflammatory reaction in allergic asthma models [101][102][103].…”

Section: Nmifs In the Treatment Of Autoimmune Diseasesmentioning

confidence: 99%

Nematode Orthologs of Macrophage Migration Inhibitory Factor (MIF) as Modulators of the Host Immune Response and Potential Therapeutic Targets

et al. 2022

View full text Add to dashboard Cite

One of the adaptations of nematodes, which allows long-term survival in the host, is the production of proteins with immunomodulatory properties. The parasites secrete numerous homologs of human immune mediators, such as macrophage migration inhibitory factor (MIF), which is a substantial regulator of the inflammatory immune response. Homologs of mammalian MIF have been recognized in many species of nematode parasites, but their role has not been fully understood. The application of molecular biology and genetic engineering methods, including the production of recombinant proteins, has enabled better characterization of their structure and properties. This review provides insight into the current state of knowledge on MIF homologs produced by nematodes, as well as their structure, enzymatic activity, tissue expression pattern, impact on the host immune system, and potential use in the treatment of parasitic, inflammatory, and autoimmune diseases.

show abstract

Can the Study of Parasitic Helminths Be Fruitful for Human Diseases?

Rzepecka

Harnett

2022

Helminth Infections and Their Impact on Global Public Health

View full text Add to dashboard Cite

Immunomodulatory effect of different extracts from Angiostrongylus cantonensis on airway inflammation in an allergic asthma model

Cited by 3 publications

References 37 publications

Immunologic, genetic, and ecological interplay of factors involved in allergic diseases

Immunologic, genetic, and ecological interplay of factors involved in allergic diseases

Nematode Orthologs of Macrophage Migration Inhibitory Factor (MIF) as Modulators of the Host Immune Response and Potential Therapeutic Targets

Can the Study of Parasitic Helminths Be Fruitful for Human Diseases?

Contact Info

Product

Resources

About