Immunomodulatory Effect of the Polysaccharide-Rich Fraction from Sclerotium of Medicinal Mushroom Poria cocos F.A. Wolf (Aphyllophoromycetideae) on Balb/c Mice

Ma, Chia-Yu; Chang, Wenxiu; Chang, Hung-Chi; Wu, James Swi‐Bea

doi:10.1615/intjmedmushr.v12.i2.10

Cited by 12 publications

(6 citation statements)

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“…Studies showed that PCP could enhance host immune function and activate the immune response . It is reported that PCPs could modulate their specific immune response via the activation of T cells . Pachymaran strongly enhances the generation of alloreactive cytotoxic T lymphocytes in vivo .…”

Section: Pharmacological Activities Of Pcpmentioning

confidence: 99%

Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China

Zeng

et al. 2018

J Cellular Molecular Medi

131

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Poria cocos is an edible medicinal fungus known as “Fuling” in Chinese and has been used as a Chinese traditional medicine for more than two thousand years. Pharmacological studies reveal that polysaccharide is the most abundant substance in Poria cocos and has a wide range of biological activities including antitumour, immunomodulation, anti‐inflammation, antioxidation, anti‐ageing, antihepatitis, antidiabetics and anti‐haemorrhagic fever effects. As a result, “Poria cocos polysaccharide oral solution” was developed and sold as an over‐the‐counter health supplement since 1970s. In 2015, “Polysaccharidum of Poria cocos oral solution” was approved as a drug by Chinese Food and Drug Administration for treating multiple types of cancers, hepatitis and other diseases alone or during chemo‐ or radiation therapy for patients with cancer. In this article, biochemical, preclinical and clinical studies of Poria cocos polysaccharide from 72 independent studies during the past 46 years (1970‐2016) based on PubMed, VIP (Chongqing VIP Chinese Scientific Journals Database), CNKI (China National Knowledge Infrastructure) and Wanfang database searches are summarized. The structure, pharmacological effects, clinical efficacy, immunobalancing molecular mechanism and toxicity of Poria cocos polysaccharide are deliberated to provide a general picture of Poria cocos polysaccharide as a clinically used antitumour drug.

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Section: Pharmacological Activities Of Pcpmentioning

confidence: 99%

Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China

Zeng

et al. 2018

J Cellular Molecular Medi

131

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“…In 1995, Wang et al demonstrated that two PPs (P1 and P2) could enhance humoral and innate immunity at very low dose . Recently, studies showed that PPs could improve adaptive immunity in vivo by activating T cells and improve hyperglycemia, hyperlipidemia, and hepatic steatosis by modulating gut microbiota . Moreover, PPs also exhibited suppressing effects toward inflammation and angiogenesis .…”

Section: Introductionmentioning

confidence: 99%

Poria cocos Polysaccharides Alleviates Chronic Nonbacterial Prostatitis by Preventing Oxidative Stress, Regulating Hormone Production, Modifying Gut Microbiota, and Remodeling the DNA Methylome

Liu

Peng

2020

J. Agric. Food Chem.

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Chronic nonbacterial prostatitis (CNP) is a common male disease with high incidence and low cure rate. This study aims to investigate the anti-CNP potential of Poria cocos polysaccharides (PPs) in a λ-carrageenan-induced CNP rat model. Results showed that PPs exerted anti-CNP functions by reducing the prostate weight and prostate index as well as the level of C-reactive protein (CRP) and pro-inflammatory cytokines (TNF-α and IL-1β). Further analysis on sex hormones revealed that PPs could favor CNP alleviation by regulating the production of testosterone (T), dihydrotestosterone (DTH), and estradiol (E2). PPs could also alleviate CNP by regulating the level of inducible nitric oxide synthase (iNOS), malonaldehyde (MDA), and superoxide diamutase (SOD) in inflamed prostate, thereby enhancing the anti-oxidative stress activity. As most non-digestive polysaccharides are fermented by gut microbiota rather than being digested directly by the host, we further analyzed PP-induced changes in gut microbiota. Microbiomic analysis revealed that PPs significantly change the profile of gut microbiota. Moreover, the relative abundance of five genera was recovered by PPs with a dose−effect relationship, thereby being suggested to play critical roles in the alleviation of CNP. Epigenomic (methylomic) analysis showed that PPs remodeled the DNA methylome of intestinal epithelia, by which PPs might modify hormone production. In the present study, we reported the anti-CNP activity of PPs as well as the involved mechanisms.

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“…Poria cocos (Schw.) Wolf is widely used in Yunnan, Guizhou, Hubei, Anhui, Fujian, Sichuan and Guangxi provinces in China, Modern medical research has indicated that P. cocos had comprehensive biological activities, such as antitumor [1,2,3,4,5,6,7,8,9,10,11], anti-inflammatory [12,13,14,15,16,17,18], immune-modulating [19,20], liver protecting [21,22] and so on, but particularly antitumor activity. Poria cocos (Schw.)…”

Section: Introductionmentioning

confidence: 99%

Screening and Analysis of the Potential Bioactive Components of Poria cocos (Schw.) Wolf by HPLC and HPLC-MSn with the Aid of Chemometrics

Wang

Mao

et al. 2016

Molecules

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Abstract:The aim of the present study was to establish a new method based on Similarity Analysis (SA), Cluster Analysis (CA) and Principal Component Analysis (PCA) to determine the quality of different samples of Poria cocos (Schw.) Wolf obtained from Yunnan, Hubei, Guizhou, Fujian, Henan, Guangxi, Anhui and Sichuan in China. For this purpose 15 samples from the different habitats were analyzed by HPLC-PAD and HPLC-MS n . Twenty-three compounds were detected by HPLC-MS n , of which twenty compounds were tentatively identified by comparing their retention times and mass spectrometry data with that of reference compounds and reviewing the literature. The characteristic fragmentations were summarized. 3-epi-Dehydrotumulosic acid (F13), 3-oxo-16α,25-dihydroxylanosta-7,9(11),24(31)-trien-21-oic acid (F4), 3-oxo-6,16α-dihydroxylanosta-7,9(11), 24(31)-trien-21-oic acid (F7) and dehydropachymic acid (F15) were deemed to be suitable marker compounds to distinguish between samples of different quality according to CA and PCA. This study provides helpful chemical information for further anti-tumor activity and active mechanism research on P. cocos. The results proved that fingerprint combined with a chemometric approach is a simple, rapid and effective method for the quality discrimination of P. cocos.

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Immunomodulatory Effect of the Polysaccharide-Rich Fraction from Sclerotium of Medicinal Mushroom Poria cocos F.A. Wolf (Aphyllophoromycetideae) on Balb/c Mice

Cited by 12 publications

References 0 publications

Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China

Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China

Poria cocos Polysaccharides Alleviates Chronic Nonbacterial Prostatitis by Preventing Oxidative Stress, Regulating Hormone Production, Modifying Gut Microbiota, and Remodeling the DNA Methylome

Screening and Analysis of the Potential Bioactive Components of Poria cocos (Schw.) Wolf by HPLC and HPLC-MSn with the Aid of Chemometrics

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