Immunomodulatory effects induced by intramuscular administration of autologous total immunoglobulin G in patients with atopic dermatitis

Intramuscular administration of autologous total immunoglobulin G induces immunomodulatory effects on T cells in healthy human subjects

“…In this study, the percentage of IL-10-producing CD4 + T cells increased significantly at week 8 and reached a peak at week 12 after intramuscular administrations of autologous total IgG in healthy human subjects. These results are consistent with the pattern of changes in serum levels of IL-10, which are also significantly increased at week 4, with the peak level reached at week 12 after the injections of the same amount of autologous total IgG for the same time period in adult patients with severe atopic dermatitis in our previous study [25] . These results collectively suggest that T cell activation induced by intramuscular administration of autologous total IgG has characteristics of delayed onset and prolonged effect in human subjects.…”

“…To prove the concept, we evaluated the clinical efficacy, safety, and immunomodulatory effect of intramuscular administration of autologous total IgG in 20 adult patients with severe atopic dermatitis as an open-labeled prospective single-arm pilot clinical trial [16,23–25] . In that study, intramuscular administration of 50 mg autologous total IgG twice a week for 4 weeks significantly decreased the clinical severity scores of atopic dermatitis and serum total IgE levels, and significantly increased serum levels of IL-10 and interferon-gamma (IFN-γ) at weeks 4, 8, and 12 compared to baseline (week 0) without serious adverse events [16,23–25] .…”

Cytokines and apoptosis in atopic dermatitis

“…showed strong upregulation of IL-8 in AD skin lesions, which was inversely correlated with miR-124 [ 80 ]. Also, IL-10 despite being predominantly tested in the blood [ 81 – 83 ] appears to be reflected in biopsy specimens where its level is also upregulated [ 84 ], particularly in pruritic atopic skin lesions [ 85 ].…”

Alternative Immunomodulatory and Disease-Modifying Treatment for Atopic Dermatitis: Autologous Total Immunoglobulin G

“…For the immunologic mechanisms of AIGT, the authors attempted to define immunomodulatory effects of AIGT using objective measurements of serum Ig levels, including IgE, IgG, and IgG4 and serum cytokine levels, including IL-10, IL-4, IL-12, and interferon (IFN)-γ. 7 In that study, a decrease in IgE and an increase in IgG and IgG4 (especially for Dermatophagoides farinae ) were noted. Also, the authors inferred that the main immunomodulatory effect of AIGT might be achieved through regulatory T-cell response which was suggested by the increased levels of IL-10 and IFN-γ.…”