Immunomodulatory effects of collagen hydrolysates from yak (Bos grunniens) bone on cyclophosphamide-induced immunosuppression in BALB/c mice

The objective of this study was to compare the quality and nutritional attributes of snakehead (Channa argus argus) fillets (cultured in ponds and containers) after being heated (boiling, frying, and baking). The results revealed that there were few differences in quality (flavor,color,and texture) and nutritional attributes (content of amino acid,dipeptidyl peptidase IV (DPP-IV) and angiotensin I-converting enzyme (ACE) inhibition activity, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity) of snakehead fillets obtained from two cultured modes. Container-cultured samples exhibited more beneficial effects on flavor (more esters) and bioactivity (ACE inhibition and DPPH scavenging activity) than pondcultured. Frying increased flavor attributes but decreased nutritional value of fish. Boiling was an effective heating method for increasing quality and nutritional attributes of container-cultured snakehead fish. Generally, the container-cultured mode was applicable for culturing snakehead without decreasing quality and nutritional attributes, which deserved more attention.

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“…The molecular distribution of the digested products was measured by the method of our previous study (Gao et al., 2019).…”

Section: Methodsmentioning

confidence: 99%

Comparison of quality and nutritional attributes of pond‐cultured and container‐cultured snakehead (Channa argus argus) fillets after being boiled, fried, and baked

Gao

Hong

et al. 2020

Journal of Food Science

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“…Both depend on some immune organs, such as the spleen, thymus, and immune cells (natural killer cells, macrophages, splenocytes, etc. ), which represent role significantly in increasing the body’s immunity [ 47 , 48 ]. Immunomodulation, which is very essential for healthy growth, can change and maintain the level of the immune response to a desired level [ 49 ].…”

Section: Introductionmentioning

confidence: 99%

Sulfaguanidine Hybrid with Some New Pyridine-2-One Derivatives: Design, Synthesis, and Antimicrobial Activity against Multidrug-Resistant Bacteria as Dual DNA Gyrase and DHFR Inhibitors

et al. 2021

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Herein, a series of novel hybrid sulfaguanidine moieties, bearing 2-cyanoacrylamide 2a–d, pyridine-2-one 3–10, and 2-imino-2H-chromene-3-carboxamide 11, 12 derivatives, were synthesized, and their structure confirmed by spectral data and elemental analysis. All the synthesized compounds showed moderate to good antimicrobial activity against eight pathogens. The most promising six derivatives, 2a, 2b, 2d, 3a, 8, and 11, revealed to be best in inhibiting bacterial and fungal growth, thus showing bactericidal and fungicidal activity. These derivatives exhibited moderate to potent inhibition against DNA gyrase and DHFR enzymes, with three derivatives 2d, 3a, and 2a demonstrating inhibition of DNA gyrase, with IC50 values of 18.17–23.87 µM, and of DHFR, with IC50 values of 4.33–5.54 µM; their potency is near to that of the positive controls. Further, the six derivatives exhibited immunomodulatory potential and three derivatives, 2d, 8, and 11, were selected for further study and displayed an increase in spleen and thymus weight and enhanced the activation of CD4+ and CD8+ T lymphocytes. Finally, molecular docking and some AMED studies were performed.

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“…In recent years, decreased resistance, depressed immunity and recurrent infections have been attributed to environmental pollution, enormous stress as well as prolonged application of corticosteroids and immunosuppressive agents 2–4 . The immune system is a rigid defense barrier to monitor and regulate body functions, and dysfunction of each aspect in the immune system can lead to inflammatory diseases, autoimmune diseases and even cancers 5–7 . Cyclophosphamide (CPA) is a highly effective alkylated anticancer drug widely used as antineoplastic agent.…”

Section: Introductionmentioning

confidence: 99%

The immunomodulatory effects of Carapax Trionycis ultrafine powder on cyclophosphamide‐induced immunosuppression in Balb/c mice

et al. 2020

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BACKGROUND There are abundant resources of Carapax Trionycis from soft‐shelled turtle processing wastes each year in China. Our preliminary work showed that Carapax Trionycis ultrafine powder (CTUP) obtained using ball‐milling with a particle size of 2.24 μm (D0.025) contained more active ingredients. The CTUP D0.025 has a good bioaccessibility, but there has been no report about the immunomodulatory function of CTUP. Therefore, using a cyclophosphamide‐induced immunosuppression mice model, we investigated the immunomodulatory effects of CTUP D0.025. RESULTS The results indicated that CTUP D0.025 administration significantly improved the immune organ (bone marrow, thymus and spleen) indices, ameliorated spleen tissue morphology and increased the capacity of splenocyte proliferation and the activity of macrophage phagocytosis. CTUP D0.025 also significantly promoted the secretion of cytokines (IL‐2, IL‐4, IL‐10, IFN‐γ and TNF‐α), improved the related mRNA expression levels of IL2, IFN‐γ, T‐bet and GATA3 in immunosuppressed mice and increased the production of serum hemolysin and the levels of IgG, IgM as well as complement C3. Moreover, CTUP D0.025 administration enhanced the antioxidant capacity of mice, exhibited a moderating effect on the damage of bone and skeletal muscle and improved the recovery of bone mineral density and calcium metabolism. CONCLUSIONS These findings demonstrated that CTUP D0.025 had an effective immune‐enhancing function in immunosuppressive Balb/c mice and also exhibited anti‐osteoporosis properties. © 2020 Society of Chemical Industry

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Immunomodulatory effects of collagen hydrolysates from yak (Bos grunniens) bone on cyclophosphamide-induced immunosuppression in BALB/c mice

Cited by 57 publications

References 50 publications

Comparison of quality and nutritional attributes of pond‐cultured and container‐cultured snakehead (Channa argus argus) fillets after being boiled, fried, and baked

Comparison of quality and nutritional attributes of pond‐cultured and container‐cultured snakehead (Channa argus argus) fillets after being boiled, fried, and baked

Sulfaguanidine Hybrid with Some New Pyridine-2-One Derivatives: Design, Synthesis, and Antimicrobial Activity against Multidrug-Resistant Bacteria as Dual DNA Gyrase and DHFR Inhibitors

The immunomodulatory effects of Carapax Trionycis ultrafine powder on cyclophosphamide‐induced immunosuppression in Balb/c mice

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