Immunomodulatory effects of EGCG fraction of green tea extract in innate and adaptive immunity via T regulatory cells in murine model

Kuo, Chao‐Lin; Chen, Tung-Sheng; Liou, Shaw-Yih; Hsieh, Chang-Chi

doi:10.3109/08923973.2014.953637

Cited by 51 publications

(37 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mechanism of action is uncertain but various immunomodulatory and antiproliferative properties have been proposed. 52,53 EGCG is formulated as a 10% ointment which is marketed in most European countries as Veregen â (Aresus Pharma, Strausberg, Germany) and in the UK as Catephen â (Kora Healthcare, Swords, Ireland). A 15% ointment preparation is only available in the US.…”

Section: Treatmentsmentioning

confidence: 99%

2019 IUSTI‐Europe guideline for the management of anogenital warts

Gilson

Nugent

Werner

et al. 2020

Acad Dermatol Venereol

105

View full text Add to dashboard Cite

This guideline is an update of the 2011 European Guideline for the Management of Anogenital Warts. It is intended to support best practice in the care of patients with anogenital warts by including evidence-based recommendations on diagnosis, treatment, follow-up and advice to patients. It is intended for use by healthcare professionals in sexual healthcare or dermato-venereology clinics in Europe but may be adapted for use in other settings where the management of anogenital warts is undertaken. As a European guideline, recommendations should be adapted according to national circumstances and healthcare systems. Despite the availability of vaccine to prevent HPV types 6 and 11, the cause of >95% anogenital warts, they remain an important and frequent health problem. The previous systematic review of randomized controlled trials for anogenital warts was updated. The changes in the present guideline include the following: Updated background information on the prevalence, natural history and transmission of human papillomavirus (HPV) infection and anogenital warts. Key recommendations for diagnosis and treatment have been graded according to the strength of the recommendation and the quality of supporting evidence. 5-fluorouracil, local interferon and photodynamic therapy have been evaluated and included as potential second-line treatment options. Evidence of the impact of HPV vaccination on the incidence of anogenital warts has been updated.

show abstract

Section: Treatmentsmentioning

confidence: 99%

2019 IUSTI‐Europe guideline for the management of anogenital warts

Gilson

Nugent

Werner

et al. 2020

Acad Dermatol Venereol

105

View full text Add to dashboard Cite

show abstract

“…Resveratrol is a polyphenolic compound isolated from plants and has been demonstrated to reduce inflammation and oxidative stress in preclinical endometriosis models [125,126]. Epigallocatechin gallate (EGCg) is a green tea extract that exerts immunomodulation activities via increased peritoneal phagocytic activity and NK cell cytolysis [127]. EGCg has been shown to inhibit angiogenesis, fibrosis, and endometriotic cell growth in preclinical models, and a phase II clinical trial is currently ongoing (Clinical Trials.gov ID: NCT02832271) [128].…”

Section: Targeting Inflammation For Treatment Of Endometriosis-assmentioning

confidence: 99%

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

Lin

Chen

Chang

et al. 2018

IJMS

140

104

View full text Add to dashboard Cite

Endometriosis is an estrogen-dependent inflammatory disease that affects up to 10% of women of reproductive age and accounts for up to 50% of female infertility cases. It has been highly associated with poorer outcomes of assisted reproductive technology (ART), including decreased oocyte retrieval, lower implantation, and pregnancy rates. A better understanding of the pathogenesis of endometriosis-associated infertility is crucial for improving infertility treatment outcomes. Current theories regarding how endometriosis reduces fertility include anatomical distortion, ovulatory dysfunction, and niche inflammation-associated peritoneal or implantation defects. This review will survey the latest evidence on the role of inflammatory niche in the peritoneal cavity, ovaries, and uterus of endometriosis patients. Nonhormone treatment strategies that target these inflammation processes are also included. Furthermore, mesenchymal stem cell-based therapies are highlighted for potential endometriosis treatment because of their immunomodulatory effects and tropism toward inflamed lesion foci. Potential applications of stem cell therapy in treatment of endometriosis-associated infertility in particular for safety and efficacy are discussed.

show abstract

“…The catechin polyphenols, such as epicatechin, epigallocatechin, epicatechin-3-gallate, and EGCG, are the major components responsible for the beneficial effects of green tea [11,12]. The anti-inflammatory and anticarcinogenic effects of these catechin polyphenols have been demonstrated in many animal and epidemiologic studies [13][14][15]. Among these polyphenols, EGCG is the most abundant component with potent antioxidant activity [16].…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin-3-gallate ameliorates autoimmune arthritis by reciprocal regulation of T helper-17 regulatory T cells and inhibition of osteoclastogenesis by inhibiting STAT3 signaling

Lee

Jung²,

Ryu

et al. 2016

Journal of Leukocyte Biology

View full text Add to dashboard Cite

The green tea polyphenol epigallocatechin-3-gallate is a potent antioxidant. Here, we describe the effects of epigallocatechin-3-gallate on T cell differentiation and osteoclast differentiation in an animal model of arthritis. Mice with collagen-induced arthritis were injected intraperitoneally with epigallocatechin-3-gallate, 3 times/wk after the primary immunization. Surface markers of T helper 17 cells and regulatory T cells were analyzed by flow cytometry. Flow cytometry, Western blotting, and enzyme-linked immunosorbent assays were used to evaluate the effect of epigallocatechin-3-gallate on cell signaling in the collagen-induced arthritis model. Epigallocatechin-3-gallate decreased the arthritis index and showed protective effects against joint destruction in collagen-induced arthritis mice. The expression of cytokines, oxidative stress proteins, and phosphorylated-signal transducer and activator of transcription-3, 705 and 727, were significantly less in mice treated with epigallocatechin-3-gallate than it was in controls. Epigallocatechin-3-gallate reduced the expression of osteoclast markers in vitro and in vivo relative to the control, and the antiosteoclastic activity was observed in epigallocatechin-3-gallate-treated, interferon-γ knockout mice. The proportion of forkhead box protein 3-positive regulatory T cells was increased in the spleens of mice treated with epigallocatechin-3-gallate compared with control mice, whereas the proportion of T helper 17 cells was reduced. In vitro, the expression of nuclear respiratory factor 2, heme oxygenase-1, and extracellular signal-regulated kinase was increased significantly by epigallocatechin-3-gallate. We demonstrated that the administration of epigallocatechin-3-gallate attenuated the symptoms of arthritis, inhibited osteoclastogenesis and T helper 17 cell activation, and increased the number of regulatory T cells. At the molecular level, the antiarthritic effects of epigallocatechin-3-gallate may be due to induction of phosphorylated-extracellular signal-regulated kinase, nuclear respiratory factor 2, and heme oxygenase-1 and inhibition of signal transducer and activator of transcription-3 activation.

show abstract

Immunomodulatory effects of EGCG fraction of green tea extract in innate and adaptive immunity via T regulatory cells in murine model

Cited by 51 publications

References 38 publications

2019 IUSTI‐Europe guideline for the management of anogenital warts

2019 IUSTI‐Europe guideline for the management of anogenital warts

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

Epigallocatechin-3-gallate ameliorates autoimmune arthritis by reciprocal regulation of T helper-17 regulatory T cells and inhibition of osteoclastogenesis by inhibiting STAT3 signaling

Contact Info

Product

Resources

About