Immunomodulatory effects of secondary metabolites from thermophilic Anoxybacillus kamchatkensis XA-1 on carp, Cyprinus carpio

Wang, Gao‐Xue; Wang, Yong; Wu, Zong-Fan; Jiang, Haifeng; Dong, Rui-Qiang; Li, Fuyuan; Liu, Xiaolin

doi:10.1016/j.fsi.2011.03.011

Cited by 29 publications

(12 citation statements)

References 45 publications

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“…Liu et al (2011) demonstrated that secondary metabolite cyclo-( L -Pro-Gly), isolated from Anoxybacillus flavithermus SX-4 could enhance non-specific immunity and disease resistance in carp ( Cyprinus carpio ). Isolated secondary metabolites from the soil isolate B. simplex increased cytokine responses and disease resistance against Aeromonas hydrophila challenge in C. carpio (Wang et al, 2011). Recently, Rajeswari et al (2016) demonstrated that phospholipid biosurfactant from Staphylococcus hominis significantly enhanced specific and non-specific immunity as well as disease resistance in Oreochromis mossambicus .…”

Section: Introductionmentioning

confidence: 99%

Role of Bacillus licheniformis VS16-Derived Biosurfactant in Mediating Immune Responses in Carp Rohu and its Application to the Food Industry

et al. 2017

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Multifarious applications of Bacillus licheniformis VS16-derived biosurfactant were explored. Labeo rohita fingerlings were injected intraperitoneally with 0.1 mL of phosphate-buffered saline (PBS) containing purified biosurfactant at 0 (control), 55 (S55), 110 (S110), 220 (S220), or 330 (S330) μg mL-1 concentrations. Various immunological parameters and the expression of immune-related genes were measured at 7, 14, and 21 days post-administration (dpa). At 21 dpa, fish were challenged with Aeromonas hydrophila and mortality was recorded for 14 days. Immune parameters such as lysozyme levels (39.29 ± 2.14 U mL-1), alternative complement pathway (61.21 ± 2.38 U mL-1), and phagocytic activities (33.37 ± 1.2%) were maximum (P < 0.05) in the S220 group at 14 dpa; but immunoglobulin levels (11.07 ± 0.83 mg mL-1) were highest in the S220 group at 7 dpa, compared to that in controls. Activities of digestive enzymes (amylase, protease, and lipase) were higher (P < 0.05) in the S220 and S330 groups than in the control group. Regarding cytokine gene expression, pro-inflammatory cytokines (TNF-α and IL-1β) were down-regulated (P < 0.05) in the S220 and S330 groups. Expression of IL-10, TGF-β, and IKB-α were up-regulated in the S220 and S330 groups at 14 dpa, with the highest levels in the S220 group. The expression of NF-κB p65 and IKK-β were down-regulated in treatment groups, and were lowest (P < 0.05) in the S220 group. The highest post-challenge survival rate (72.7%) was recorded in S220 group. Further, the potential of this substance to inhibit biofilm formation, and heavy metal removal from vegetables were also evaluated. Biosurfactant was effective in inhibiting biofilm formation up to 54.71 ± 1.27%. Moreover, it efficiently removed cadmium (Cd) from tested vegetables such as carrot, radish, ginger, and potato, with the highest removal efficiency (60.98 ± 1.29%) recorded in ginger contaminated with Cd. Collectively, these results suggest that isolated biosurfactant could be used in the aquaculture industry, in addition to its potential application to the food industry.

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Section: Introductionmentioning

confidence: 99%

Role of Bacillus licheniformis VS16-Derived Biosurfactant in Mediating Immune Responses in Carp Rohu and its Application to the Food Industry

et al. 2017

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“…A number of studies have identified immunomodulatory compartments of microbial products such as bacterial toxins, bacterial polysaccharides and secondary metabolites that have poteintal in treating certain pathological situations [2,4,6,[17][18][19][20][21][22][23][24][25][26][27][28]. Several substances, including components of bacterial cell walls, have been reported to modulate innate immune responses [1,7,19,20].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, several studies have evaluated the potential of secondary metabolites isolated from soil samples for regulation of innate immunity in fish aquaculture. [4,19,20]. In addition, secondary metabolites from marine Pseudomonas sp.…”

Section: Discussionmentioning

confidence: 99%

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The immunomodulatory activity of secondary metabolites isolated fromStreptomyces calvuson human peripheral blood mononuclear cells

Mahmoudi

Baradaran

Dehnad

et al. 2016

British Journal of Biomedical Science

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“…Furthermore, Wang et al . () isolated two compounds from the secondary metabolites of Anoxybacillus kamchatkensis XA‐1, themselves isolated from the hot springs in Xi'an, China. Intraperitoneal injection of these compounds at a dose of 20 mg kg −1 BW conferred high levels of protection to C. carpio against A. hydrophila infection.…”

Section: Efficacy Of Bacterial Subcellular Components Against Fish Pamentioning

confidence: 97%

Use of bacterial subcellular components as immunostimulants in fish aquaculture

Giri

Chi

Jun

et al. 2016

Reviews in Aquaculture

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Aquaculture and fisheries products are expected to play a leading part in addressing the food necessities of the increasing human population. However, in intensive aquaculture, fish are exposed to stress conditions that deteriorate their immune systems, leading to increased disease vulnerability. These disease outbreaks have resulted in production losses and represent one of the key constraints in fish farming. Accordingly, aquaculture disease management efforts have concentrated on the establishment of environmental friendly and lasting methods. Recently, several studies have revealed that various bacteria (especially probiotics)‐derived cellular components might be used as promising immunostimulants in fish aquaculture. Such components curtail the risk concomitant with the use of antibiotics, chemotherapeutics, vaccines and probiotics. Among the various health advantages ascribed to bacterial cellular components, the modulation of specific and nonspecific immune responses, cytokine gene expression and anti‐pathogenic activities are most anticipated benefits. Their potential as vaccine adjuvants for fish culture has also been demonstrated. However, as an emerging practice, limited knowledge is available regarding the detailed interactions with fish immune systems. Therefore, the underlying mechanisms involved in fish immune cell activation need to be explored further. In this context, the present article aspires to review the available studies on the use of bacterial cellular components in fish culture and their biological effects on fish such as growth promotion, immunostimulation and anti‐pathogenic activities as well as to evaluate the factors that control the optimal induction of immune responses in fish. In addition, future issues that merit further investigation are suggested.

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Immunomodulatory effects of secondary metabolites from thermophilic Anoxybacillus kamchatkensis XA-1 on carp, Cyprinus carpio

Cited by 29 publications

References 45 publications

Role of Bacillus licheniformis VS16-Derived Biosurfactant in Mediating Immune Responses in Carp Rohu and its Application to the Food Industry

Role of Bacillus licheniformis VS16-Derived Biosurfactant in Mediating Immune Responses in Carp Rohu and its Application to the Food Industry

The immunomodulatory activity of secondary metabolites isolated fromStreptomyces calvuson human peripheral blood mononuclear cells

Use of bacterial subcellular components as immunostimulants in fish aquaculture

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