Immunomodulatory Effects of ZYM-201 on LPS-stimulated B Cells

Lee, Ye Eun; Kim, Soochan; Jung, Woo Hyun; Lee, Hyung Soo; Kim, Mi‐Yeon

doi:10.4110/in.2014.14.5.260

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…For these purposes, people are recommended to consume numerous functional foods and nutraceuticals such as taheebo, ginseng, mushrooms, and cordyceps, as well as fresh vegetables and fruits [ 5 – 7 ]. These are all great sources of valuable components with antioxidative, antiasthmatic, and anti-inflammatory properties such as flavonoids, saponins, alkaloids, terpenoids, and anthraquinones [ 8 – 11 ]. Indeed, in many different experiments with animal models, these foods have been demonstrated to display numerous beneficial pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid

Park

Kim

et al. 2016

Mediators of Inflammation

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Anthraquinone compounds are one of the abundant polyphenols found in fruits, vegetables, and herbs. However, the in vivo anti-inflammatory activity and molecular mechanisms of anthraquinones have not been fully elucidated. We investigated the activity of anthraquinones using acute inflammatory and nociceptive experimental conditions. Anthraquinone-2-carboxylic acid (9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid, AQCA), one of the major anthraquinones identified from Brazilian taheebo, ameliorated various inflammatory and algesic symptoms in EtOH/HCl- and acetylsalicylic acid- (ASA-) induced gastritis, arachidonic acid-induced edema, and acetic acid-induced abdominal writhing without displaying toxic profiles in body and organ weight, gastric irritation, or serum parameters. In addition, AQCA suppressed the expression of inflammatory genes such as cyclooxygenase- (COX-) 2 in stomach tissues and lipopolysaccharide- (LPS-) treated RAW264.7 cells. According to reporter gene assay and immunoblotting analyses, AQCA inhibited activation of the nuclear factor- (NF-) κB and activator protein- (AP-) 1 pathways by suppression of upstream signaling involving interleukin-1 receptor-associated kinase 4 (IRAK1), p38, Src, and spleen tyrosine kinase (Syk). Our data strongly suggest that anthraquinones such as AQCA act as potent anti-inflammatory and antinociceptive components in vivo, thus contributing to the immune regulatory role of fruits and herbs.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid

Park

Kim

et al. 2016

Mediators of Inflammation

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“…Interestingly, the more an SRE dose increases up to 400 μg/mL, the more proliferation of splenocytes increases and tumor proliferation decreases. There are reports of SRE inducing immunomodulatory effects including inflammatory responses and cytokine production ( 27 , 28 ). Our findings suggest that SRE would not only have a cytotoxic effect on CRC cells but also promote T cell immunity and have anticancer effects via inhibition of PD-1/PD-L1 interaction in splenocyte-tumor coculture systems.…”

Section: Discussionmentioning

confidence: 99%

Sanguisorbae Radix Suppresses Colorectal Tumor Growth Through PD-1/PD-L1 Blockade and Synergistic Effect With Pembrolizumab in a Humanized PD-L1-Expressing Colorectal Cancer Mouse Model

Lee

Kim

et al. 2021

Front. Immunol.

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Immune checkpoints such as programmed death-1 (PD-1) have been proven as antitumor targets by enhancing cytotoxic T cell activity. All immune checkpoint blockades are antibody therapeutics that have large size and high affinity, as well as known immune-related side effects and low responses. To overcome the limitation of antibody therapeutics, we have explored PD-1/PD-L1 (programmed death-ligand 1) blockades in traditional oriental medicine, which has a long history but has not yet studied PD-1/PD-L1 blockades. Sanguisorbae Radix extract (SRE) blocked PD-1 and PD-L1 binding in competitive ELISA. SRE effectively inhibited the PD-1/PD-L1 interaction, thereby improving T cell receptor (TCR) signaling and the NFAT-mediated luciferase activity of T cells. SRE treatment reduced tumor growth in the humanized PD-L1 MC38 cell allograft humanized PD-1 mouse model. Additionally, the combination of SRE and pembrolizumab (anti-PD-1 antibody) suppressed tumor growth and increased infiltrated cytotoxic T cells to a greater extent did either agent alone. This study showed that SRE alone has anticancer effects via PD-1/PD-L1 blockade and that the combination therapy of SRE and pembrolizumab has enhanced immuno-oncologic effects.

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“…Ziyuglycosides are known as primary terpenoid compounds of S. officinalis that have been reported to exhibit diverse biological actions, including anti-cancer, anti-inflammation, anti-skin aging, anti-hyperlipidemia, and hemostasis properties [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. However, anti-diabetic properties of ziyuglycosides have not been reported yet.…”

Section: Discussionmentioning

confidence: 99%

“…Ziyuglycoside II (ZG02) is a triterpenoid compound isolated from S. officinalis [ 28 ]. Previous studies demonstrated that the methyl ester form of ZG02 (ZG02-ME) plays a significant role in modulating hyperlipidemic conditions [ 29 , 30 , 31 ] and inflammatory responses [ 32 ]. Furthermore, it has been reported that ZG02-ME, which is derivatized from ziyuglycoside I (ZG01) by chemical modification, possesses an improved inhibitory activity in vivo compared with that of ZG01 on tissue factor and tumor necrosis factor (TNF)-α productions [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice

et al. 2015

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Type 2 diabetes is a metabolic disorder caused by abnormal carbohydrate metabolism, and closely associated with abnormal lipid metabolism and hepato-renal dysfunction. This study investigated the anti-diabetic and hepato-renal protective properties of ziyuglycoside I (ZG01) derivative on type 2 diabetes. ZG01 was isolated from roots of Sanguisorba officinalis and chemically modified by deglycosylation and esterification to obtained ziyuglycoside II methyl ester (ZG02-ME). Here, we showed that ZG02-ME has stronger anti-diabetic activity than the original compound (ZG01) through decreasing blood glucose, glycated hemoglobin (HbA1c), and insulin levels in a mouse model of type 2 diabetes (db/db mice). We further found that ZG02-ME treatment effectively ameliorated serum insulin, leptin and C-peptide levels, which are key metabolic hormones, in db/db mice. In addition, we showed that elevated basal blood lipid levels were decreased by ZG02-ME treatment in db/db mice. Furthermore, treatment of ZG02-ME significantly decreased serum AST, ALT, BUN, creatinine, and liver lipid peroxidation in db/db mice. These results demonstrated that compared to ZG01, chemically modified ZG02-ME possess improved anti-diabetic properties, and has hepato-renal protective activities in type 2 diabetes.

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Immunomodulatory Effects of ZYM-201 on LPS-stimulated B Cells

Cited by 8 publications

References 24 publications

Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid

Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid

Sanguisorbae Radix Suppresses Colorectal Tumor Growth Through PD-1/PD-L1 Blockade and Synergistic Effect With Pembrolizumab in a Humanized PD-L1-Expressing Colorectal Cancer Mouse Model

Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice

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