Immunomodulatory potential of flavonoids for the treatment of autoimmune diseases and tumour

Han, Limin; Fu, Qiang; Deng, Chao; Luo, Li; Xiang, Tengxiao; Zhao, Hailong

doi:10.1111/sji.13106

Cited by 29 publications

(18 citation statements)

References 213 publications

(223 reference statements)

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“…As primary effector cells of the innate immune response, T cells, a type of natural killer cell, possess the function of eliminating pathogens. 34 Thus, naringin@MIL-101 could affect T-cell proliferation by promoting the antiinflammatory effect and inhibiting the inflammatory response. We believe by further increasing the incubation time, cell confluency, or material concentrations, we can readily promote cytokine releases from naringin@MIL-101 composites, thereby inducing an increase in the immune response against EL4 T cells.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, naringin@MIL-101 could affect the activation of the immune system. As primary effector cells of the innate immune response, T cells, a type of natural killer cell, possess the function of eliminating pathogens . Thus, naringin@MIL-101 could affect T-cell proliferation by promoting the anti-inflammatory effect and inhibiting the inflammatory response.…”

Section: Resultsmentioning

confidence: 99%

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Naringin@Metal–Organic Framework as a Multifunctional Bioplatform

Wang

Chen

et al. 2022

ACS Appl. Mater. Interfaces

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Naringin, a natural product, can be used as a therapeutic agent due to its low systemic toxicity and negligible adverse effect. However, due to its hydrophobic nature and thereby low solubility, high-dose treatment is required when used for human therapy. Herein, we demonstrate the employment of a metal−organic framework (MOF) as a nontoxic loading carrier to encapsulate naringin, and the afforded nairngin@MOF composite can serve as a multifunctional bioplatform capable of treating Gram-positive bacteria and certain cancers by slowly and progressively releasing the encapsulated naringin as well as improving and modulating immune system functions through synergy between naringin and the MOF.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Naringin@Metal–Organic Framework as a Multifunctional Bioplatform

Wang

Chen

et al. 2022

ACS Appl. Mater. Interfaces

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“…However, FLAs have been documented to increase the expression of genes encoding IgA in mice ( 78 ). Likewise, various FLAs increase the number and activity of B1 and B2 lymphocytes ( 79 ), which secrete IgG and IgM ( 80 , 81 ). Therefore, similar effects of FLAs consumption in the present meta-analysis would explain the observed increases in IgA, IgG, and IgM.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of flavonoids use into beef and dairy cattle diet: Performance, antioxidant status, ruminal fermentation, meat quality, and milk composition

et al. 2023

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The objective of this study was to evaluate the effects of dietary supplementation with flavonoids (FLAs) on animal performance, diet digestibility, antioxidant status in blood serum, rumen parameters, meat quality, and milk composition in beef and dairy cattle through a meta-analysis. Thirty-six peer-reviewed publications were included in the data set. The weighted mean differences (WMD) between the FLAs treatments and the control treatment were used to assess the effect size. Dietary supplementation with FLAs decreased feed conversion ratio (WMD = −0.340 kg/kg; p = 0.050) and increased (p < 0.05) dry matter intake (WMD = 0.191 kg/d), dry matter digestibility (WMD = 15.283 g/kg of DM), and daily weight gain (WMD = 0.061 kg/d). In blood serum, FLAs supplementation decreased the serum concentration of malondialdehyde (WMD = −0.779 nmol/mL; p < 0.001) and increased (p < 0.01) the serum concentration of superoxide dismutase (WMD = 8.516 U/mL), glutathione peroxidase (WMD = 12.400 U/mL) and total antioxidant capacity (WMD = 0.771 U/mL). A higher ruminal propionate concentration (WMD = 0.926 mol/100 mol; p = 008) was observed in response to FLAs supplementation. In meat, the dietary inclusion of FLAs decreased (p < 0.05) shear force (WMD = −1.018 kgf/cm2), malondialdehyde content (WMD = −0.080 mg/kg of meat), and yellowness (WMD = −0.460). Supplementation with FLAs decreased milk somatic cell count (WMD = −0.251 × 103 cells/mL; p < 0.001) and increased (p < 0.01) milk production (WMD = 1.348 kg/d), milk protein content (WMD = 0.080/100 g) and milk fat content (WMD = 0.142/100 g). In conclusion, dietary supplementation with FLAs improves animal performance and nutrient digestibility in cattle. In addition, FLAs improve the antioxidant status in blood serum and the quality of meat and milk.

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“…Oral administration of EGCG in an MS mice model decreased the production of IFN-γ, IL-17, IL-6, IL-1β, and TNF-α. 77,78 EGCG treatment led to a decrease in Th1 and Th17 helper cells and also reduced the expression of transcription factors T-box expressed in T-cells and retinoidrelated orphan receptor-γt, which is a transcription factor specific to Th1 and Th17 differentiation (Figure 1II). 77 Thereby, EGCG has a potential role in decreasing the TRAILinduced damage of neurons and oligodendrocytes in neuroinflammatory diseases.…”

Section: Egcg: a Potential Therapeutic Molecule Againstmentioning

confidence: 99%

Epigallocatechin Gallate: A Multifaceted Molecule for Neurological Disorders and Neurotropic Viral Infections

Rani,

Saini,

Patra

et al. 2023

ACS Chem. Neurosci.

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Epigallocatechin-3-gallate (EGCG), a polyphenolic moiety found in green tea extracts, exhibits pleiotropic bioactivities to combat many diseases including neurological ailments. These neurological diseases include Alzheimer's disease, multiple sclerosis, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. For instance, in the case of Alzheimer's disease, the formation of a β-sheet in the region of the 10th−21st amino acids was significantly reduced in EGCG-induced oligomeric samples of Aβ40. Its interference induces the formation of Aβ structures with an increase in intercenter-ofmass distances, reduction in interchain/intrachain contacts, reduction in β-sheet propensity, and increase in α-helix. Besides, numerous neurotropic viruses are known to instigate or aggravate neurological ailments. It exerts an effect on the oxidative damage caused in neurodegenerative disorders by acting on GSK3-β, PI3K/Akt, and downstream signaling pathways via caspase-3 and cytochrome-c. EGCG also diminishes these viral-mediated effects, such as EGCG delayed HSV-1 infection by blocking the entry for virions, inhibitory effects on NS3/4A protease or NS5B polymerase of HCV and potent inhibitor of ZIKV NS2B-NS3pro/NS3 serine protease (NS3-SP). It showed a reduction in the neurotoxic properties of HIV-gp120 and Tat in the presence of IFN-γ. EGCG also involves numerous viral-mediated inflammatory cascades, such as JAK/STAT. Nonetheless, it also inhibits the Epstein−Barr virus replication protein (Zta and Rta). Moreover, it also impedes certain viruses (influenza A and B strains) by hijacking the endosomal and lysosomal compartments. Therefore, the current article aims to describe the importance of EGCG in numerous neurological diseases and its inhibitory effect against neurotropic viruses.

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Immunomodulatory potential of flavonoids for the treatment of autoimmune diseases and tumour

Cited by 29 publications

References 213 publications

Naringin@Metal–Organic Framework as a Multifunctional Bioplatform

Naringin@Metal–Organic Framework as a Multifunctional Bioplatform

Meta-analysis of flavonoids use into beef and dairy cattle diet: Performance, antioxidant status, ruminal fermentation, meat quality, and milk composition

Epigallocatechin Gallate: A Multifaceted Molecule for Neurological Disorders and Neurotropic Viral Infections

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