Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc commune

Liao, Hui-Fen; Wu, Tai-Jung; Tai, Jia-Liang; Chi, Meng-Chun; Lin, Long-Liu

doi:10.3390/medsci3040112

Cited by 14 publications

(11 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, the polysaccharide is mostly β -1, 3 and β -1, 4 glycoside bonds, which are not easy to be absorbed by the intestinal tract, and it has strong moisture absorption, moisture retention, and high relative viscosity [ 9 , 13 , 14 ]. Studies have shown that NSKP has rich biological activities, including anti-inflammatory and lipid-lowering effects [ 15 – 17 ]. However, there are a few studies on moistening intestines and the laxative effect of NSKP.…”

Section: Introductionmentioning

confidence: 99%

Nostoc sphaeroides Kütz Polysaccharide Improved Constipation and Promoted Intestinal Motility in Rats

Liu

Yang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Natural products and medicinal foods have attracted more and more attention because of their potential prevention and inhibition effect on constipation. Nostoc sphaeroides Kütz Polysaccharide (NSKP) polysaccharide is a natural product rich in polysaccharides. This work attempted to prove the effects of aqueous extracts of NSKP on STC treatment and to determine the possible mechanisms by a loperamide-induced slow transit constipation (STC) model. The results show that, in rats of the NSKP group, compared with the model group, the colon propulsion rate was improved, the time of the first grain of black stool was shortened, and the fecal wet weight was increased remarkably. The 5-HT levels were increased, but the VIP and NO levels were reduced dramatically. The number of interstitial cells of cajal (ICC) was increased by c-kit/SCF signal pathway, and the intestines were moisturized; then, constipation was relieved. It is interesting to note that NSKP appeared to be effective on constipation, so further experiments are necessary to clarify the exact mechanisms involved.

show abstract

Section: Introductionmentioning

confidence: 99%

Nostoc sphaeroides Kütz Polysaccharide Improved Constipation and Promoted Intestinal Motility in Rats

Liu

Yang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Similarly, Nostoc is an edible, largely consumed cyanobacterial form after Spirulina. Polysaccharide-rich extracts of Nostoc commune could be potentially used for macrophage activation and consequently inhibit the leukemic cell growth and induce monocytes/macrophages when used to treat human monoblastoid leukemia U937 cells [73]. Different immunomodulating activities of Microcystis aeruginosa, Synechocystis aquatilis, Oscillatoria redekei, Anabaena flos-aque, Aphanizomenon flos-aquae, Oscillatoria rubescens, Oscillatoria tenuis have also been reported [74] their different cell extracts variably promote the proliferation of lymphocytes.…”

Section: Immunomodulatory and Anti-inflammatory Effectsmentioning

confidence: 99%

Potential of Cyanobacteria in Wound Healing

Parwani¹,

Shrivastava²,

Singh³

2022

Cyanobacteria - Recent Advances in Taxonomy and Applications

View full text Add to dashboard Cite

The wound care market is rapidly expanding due to the development of innumerable dressings that exhibit specific healing requirements for different wound types. The use of biomaterials as suitable wound dressing material is highly advantageous due to their biocompatibility, biodegradability, and non-toxicity. Cyanobacteria have been widely explored for their potential applications in wound healing, as they are the rich source of bioactive compounds with antibacterial, antitumor, antiviral, antioxidant, and antifungal activities. In recent years this group of organisms has been widely studied due to their immense potential in biomedical applications. Although their different bioactivities can support wound healing in different ways, very few forms have proven utility as a wound-healing agent. This chapter gives an insight into the potential of cyanobacteria in wound healing. Different bioactive compounds present in variable forms of cyanobacteria and their associated activities were reported to support tissue regeneration and wound healing acceleration. As the demand for cost-effective, bioactive wound care products is ever increasing, these organisms have immense potential to be utilized for the development of bioactive wound dressings. Hence, various bioactive compounds of cyanobacteria, their associated activities, and roles in wound healing have been briefly reviewed in this chapter.

show abstract

“…There is one major thing that all the polymers have in common: the higher amount of 1,3 substituted glucose units [ 11 ]. Liao et al also reported the immunomodulatory potential of the polysaccharide-rich extract from N. commune (NCPS) and found that the immunity of murine macrophage Raw 264.7 cells might be activated by nitric oxide and superoxide secretion and consequently effectively inhibit the growth of human leukemic U937 cells as well as trigger the differentiation of U937 monoblast cells into monocytic/macrophagic lines resulting from the upregulation of GM-CSF and IL-1β as well as the downregulation of IL-6 and IL-17 [ 65 ]. Taken together, these studies demonstrated that N. commune may have potential as a cancer chemopreventative agent.…”

Section: Anti-carcinogenic and Immunomodulatory Properties Of mentioning

confidence: 99%

Healthy efficacy ofNostoc communeVaucher

Guo

2017

Oncotarget

View full text Add to dashboard Cite

Nostoc commune Vaucher, a macroscopic cyanobacterium, has long been appreciated as a healthy food and traditional medicine worldwide. Accumulated evidence has demonstrated that it possesses a wide range of remarkably protective physiological and pharmacological activities, largely based on animal and in vitro studies. In this review, we summarise and update evidence regarding the chemical composition and nutritional characteristics of Nostoc commune Vaucher, and comprehensively discuss the recent studies on the antioxidative, anti-inflammatory, anti-carcinogenic and immune regulation properties of Nostoc commune Vaucher and Nostoc commune Vaucher-derived extracts. The available results demonstrate the potential of it to act as a functional food for the amelioration of human associated diseases. More details from human clinical trials should be a matter of further investigation.

show abstract

Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc commune

Cited by 14 publications

References 36 publications

Nostoc sphaeroides Kütz Polysaccharide Improved Constipation and Promoted Intestinal Motility in Rats

Nostoc sphaeroides Kütz Polysaccharide Improved Constipation and Promoted Intestinal Motility in Rats

Potential of Cyanobacteria in Wound Healing

Healthy efficacy ofNostoc communeVaucher

Contact Info

Product

Resources

About