Immunomodulatory properties of human placental mesenchymal stem/stromal cells

Abumaree, Mohamed; Abomaray, Fawaz; Alshabibi, Manal A.; Alaskar, Ahmed; Kalionis, Bill

doi:10.1016/j.placenta.2017.04.003

Cited by 96 publications

(79 citation statements)

References 90 publications

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“…Although placenta-derived MSCs also have immunomodulatory effects, their relative immunomodulatory capacity compared with other tissue origins is contradictory [229,230]. MSCs isolated from neonatal sources like placenta, umbilical cord, and umbilical cord blood also express high level of HLA-G, a critical surface antigen responsible for inducing immunotolerance and allowing fetal tissues to coexist with maternal immune system during pregnancy [231,232]. The presence of HLA-G on neonatal MSCs may therefore make them favorable cell therapy candidates for allogeneic transplantation.…”

Section: Cell-based Therapy For Endometriosis Treatmentmentioning

confidence: 99%

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

Lin

Chen

Chang

et al. 2018

IJMS

140

104

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Endometriosis is an estrogen-dependent inflammatory disease that affects up to 10% of women of reproductive age and accounts for up to 50% of female infertility cases. It has been highly associated with poorer outcomes of assisted reproductive technology (ART), including decreased oocyte retrieval, lower implantation, and pregnancy rates. A better understanding of the pathogenesis of endometriosis-associated infertility is crucial for improving infertility treatment outcomes. Current theories regarding how endometriosis reduces fertility include anatomical distortion, ovulatory dysfunction, and niche inflammation-associated peritoneal or implantation defects. This review will survey the latest evidence on the role of inflammatory niche in the peritoneal cavity, ovaries, and uterus of endometriosis patients. Nonhormone treatment strategies that target these inflammation processes are also included. Furthermore, mesenchymal stem cell-based therapies are highlighted for potential endometriosis treatment because of their immunomodulatory effects and tropism toward inflamed lesion foci. Potential applications of stem cell therapy in treatment of endometriosis-associated infertility in particular for safety and efficacy are discussed.

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Section: Cell-based Therapy For Endometriosis Treatmentmentioning

confidence: 99%

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

Lin

Chen

Chang

et al. 2018

IJMS

140

104

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“…Ethical concerns related to the derivation of PL-MSCs should be disregarded by the fact that placental tissues are normally considered medical waste and can be recovered without harm to the donor or fetus (27). Bearing in mind the simplicity of the harvesting procedure for isolation of PL-MSCs and their huge therapeutic potential (28,29), we recently developed: "Exosomes Derived Multiple Allogeneic Proteins Paracrine Signaling, Exosomes d-MAPPS", biological product which activity is based on placental derived biomaterials, growth factors, and immunomodulatory cytokines capable to attenuate inflammation and to promote regeneration of injured tissues. Herewith, we analyzed and discussed in detail concentrations of bio-active molecules in Exosomes d-MAPPS emphasizing its therapeutic potential in regenerative medicine.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of “Exosomes Derived Multiple Allogeneic Proteins Paracrine Signaling: Exosomes d-MAPPS” is Based on the Effects of Exosomes, Immunosuppressive and Trophic Factors

Harrell¹,

Fellabaum²,

Marković

et al. 2019

Serbian Journal of Experimental and Clinical Research

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Due to their differentiation capacity and potent immunosuppressive and pro-angiogenic properties, mesenchymal stem cells (MSCs) have been considered as new therapeutic agents in regenerative medicine. Since most of MSC-mediated beneficent effects are a consequence of their paracrine action, we designed MSC-based product “Exosomes Derived Multiple Allogeneic Proteins Paracrine Signaling (Exosomes d-MAPPS), which activity is based on MSCs-derived growth factors and immunomodulatory cytokines capable to attenuate inflammation and to promote regeneration of injured tissues. Interleukin 1 receptor antagonist (IL-1Ra) and IL-27 were found in high concentrations in Exosomes d-MAPPS samples indicating strong anti-inflammatory and immunosuppressive potential of Exosomes d-MAPPS. Additionally, high concentrations of vascular endothelial growth factor receptor (VEGFR1) and chemokines (CXCL16, CCL21, CXCL14) were noticed at Exosomes d-MAPPS samples suggesting their potential to promote generation of new blood vessels and migration of CXCR6, CCR7 and CXCR4 expressing cells. Since all proteins which were found in high concentration in Exosomes d-MAPPS samples (IL-1Ra, CXCL16, CXCL14, CCL21, IL-27 and VEGFR1) are involved in modulation of lung, eye, and synovial inflammation, Exosomes d-MAPPS samples were prepared as inhalation and ophthalmic solutions in addition to injection formulations; their application in several patients suffering from chronic obstructive pulmonary disease, osteoarthritis, and dry eye syndrome resulted with significant improvement of biochemical and functional parameters. In conclusion, Exosomes d-MAPPS, due to the presence of important anti-inflammatory, immunomodulatory, and pro-angiogenic factors, represents potentially new therapeutic agent in regenerative medicine that should be further tested in large clinical studies.

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“…The immunoregulatory properties of MSCs have been shown in vitro to modulate the action of neutrophils, NK cells as well as B and T lymphocytes (Demircan et al, ; Spees et al, ). MSCs possess immunosuppressive properties and this is due to the secretion of soluble factors including HGF, TGF‐β, IDO, NO, and PGE2 (De Miguel et al, ; Abumaree et al, ; Cagliani et al, ). Paracrine factors influence the microenvironment and activate local organ‐specific progenitor populations, leading to long‐term therapeutic effects.…”

Section: Discussionmentioning

confidence: 99%

Effect of Bone Marrow‐Derived Mesenchymal Stem Cells on Cochlear Function in an Experimental Rat Model

Mittal

Ocak

Zhu

et al. 2019

The Anatomical Record

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Mesenchymal stem cell (MSC) therapy is an emerging treatment modality for various human diseases. Although induced pluripotent stem cells have been explored for the restoration of hearing, the potential of MSCs as a therapeutic strategy for various cochlear insults is not precisely known. MSCs possess anti‐inflammatory, anti‐apoptotic and neuroprotective properties, making them an attractive target for the treatment of inner ear disorders such as hair cell damage in response to inflammation. Most of the previous studies have used immunosuppression or the complex surgical techniques to deliver stem cells into the cochlea. However, no information is available regarding the biocompatibility and safety of MSCs in the inner ear in immunocompetent cochlea. The aim of the present study was to determine the effect of non‐surgical administration of rodent bone marrow derived MSCs (BM‐MSCs) through transtympanic delivery on the cochlear function and to assess any adverse effects on the auditory system employing a rat model without immunosuppression. We observed that the transtympanic administration of BM‐MSCs has no significant effect on the hearing thresholds as determined by auditory brainstem response and distortion product otoacoustic emissions. Histopathological examination revealed no recruitment of inflammatory leukocytes and edema in the cochlea of BM‐MSCs administrated rats. The results of this study suggest that transtympanic administration of BM‐MSCs is safe and can be explored in providing otoprotection against cochlear insults. Anat Rec, 303:487–493, 2020. © 2019 American Association for Anatomy

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Immunomodulatory properties of human placental mesenchymal stem/stromal cells

Cited by 96 publications

References 90 publications

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies

Therapeutic Potential of “Exosomes Derived Multiple Allogeneic Proteins Paracrine Signaling: Exosomes d-MAPPS” is Based on the Effects of Exosomes, Immunosuppressive and Trophic Factors

Effect of Bone Marrow‐Derived Mesenchymal Stem Cells on Cochlear Function in an Experimental Rat Model

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