Immunopathologic Characteristics of Nasal Polyps in Adult Koreans: A Single-Center Study

Shin, Seung‐Heon; Kim, Yee-Hyuk; Ye, Mi‐Kyung; Choi, Sung Yong

doi:10.2500/ajra.2017.31.4423

Cited by 9 publications

(11 citation statements)

References 19 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,5,11 Our finding of higher fibronectin in NE-CRS subjects compared to the other CRS groups is consistent with the results that were reported by Shin et al. 16 who found the highest levels of fibronectin RNA and protein in noneosinophilic polyps from Korean subjects. There was no difference in collagen IV expression among any of the groups.…”

Section: Discussionsupporting

confidence: 91%

Differential Expression of Extracellular Matrix Components in Nasal Polyp Endotypes

Feng

Payne

Borish

et al. 2019

Am J Rhinol�Allergy

View full text Add to dashboard Cite

Background Chronic rhinosinusitis is a difficult-to-treat disease that is often characterized by recurrent nasal polyp (NP) growth following surgical removal. The disease has been separated into distinct phenotypes based on cellular infiltrate or underlying physiological mechanisms. NPs are composed in part of an inflammatory cellular infiltrate, blood vessels, and a large amount of extracellular matrix (ECM). Despite the recognition of prominent ECM deposition, few studies have examined the components in detail and how they might differ with disease state. Objective The purpose of this study was to quantitate the expression of ECM components in NPs. Methods NPs were stained with pico-sirius red to determine total collagen content, and immunofluorescence was used to detect collagen I, collagen III, collagen IV, fibronectin, and laminin. Expression of each was quantitated and analyzed in relation to rhinosinusitis phenotype and separately as a function of polyp eosinophil number. Results When analyzed by phenotype, collagen I, collagen III, and fibronectin were expressed at the highest levels in noneosinophilic sinus disease. Collagen IV was not different among any groups, and its location was found predominately around vessels. When analyzed as a function of polyp eosinophil number, total collagen and collagen III showed a significant inverse correlation. Conclusions NP ECM composition differs with disease state with higher expression in cases where eosinophil levels are low. This suggests that in eosinophilic polyps there is a loss of matrix deposition either through break down or a failure to produce the essential components. Understanding these differences may identify new therapeutic targets.

show abstract

Section: Discussionsupporting

confidence: 91%

Differential Expression of Extracellular Matrix Components in Nasal Polyp Endotypes

Feng

Payne

Borish

et al. 2019

Am J Rhinol�Allergy

View full text Add to dashboard Cite

show abstract

“…Of note, there are several studies that addressed MMP-9 elevation in ECRS. For instance, Shin et al 30 showed that MMP-9 mRNA expression increased significantly in nasal polyps derived from patients with CRSwNP. In addition, we have previously shown that eosinophil granule protein acts on nasal epithelial cells to enhance MMP-9 production.…”

Section: Discussionmentioning

confidence: 99%

Pathological and therapeutic implications of eosinophil-derived semaphorin 4D in eosinophilic chronic rhinosinusitis

Tsuda

Nishide

Maeda

et al. 2020

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

“…Chain Reaction (PCR) (26,41,46,49,54,(56)(57)(58) and Western Blot analysis (13,29,46,49,53,54,57,59,62) were also selected by several researchers, while immunofluorescence (27,34,37,57) , Northern blot analysis (23) and Luminex (60,61) were used in a minority of studies. It is however of note that in studies where multiple methods were applied (quantitative) m-RNA and protein levels were reported to be in consistency with each other and with semi-quantitative or qualitative immunohistochemical results (26,34,41,49,57,62) .…”

Section: Studymentioning

confidence: 99%

“…Lechapt-Zalcman 2001 for all & 88-84Kd, 22 Chen 2007, 26 Can 2008, 28 Eisenberg 2008, 29 Kahveci 2008, 30 Bugdayci 2010 (allergic NP-plasma) 32 Li 2010, 34 Wang 2012, 38 2013 42 in gl of pri, Wang 2013 in gl of rec, 42 De Borja Callejas 2013 in ECM &eos, 39 Malinsky 2013, 40 Yeo 2013 rec>pri> controls, 43 Li 2015 III>II>I>controls, 46 Shin 2017 atop & non-atop, 54 Chen 2018 56 Lechapt-Zalcman 2001 for 92kD, 22 Bugdayci 2010 (non-allergic NP-plasma), 32 Van Crombruggen 2012, 37 Wang 2012, 38 Can 2008, 28 Li 2010, 34 Van Crombruggen 2012, 37 Chen 2018 56 (pri-mucus), 27 Kahveci 2008 30 Katainen 2015 (sec) 45 Kostamo 2007 (rec-mucus), 27 28 Kahveci 2008, 30 Yeo 2013 (rec & pri) 43 Chen 2007, 26 Li 2010, 34 De Borja Callejas 2013, 39 Katainen 2015 (sec & serum), 45 Vetuschi 2020 (different distribution) 62 none Li 2010 34 Can 2008 28 TIMP-2 Li 2015 (controls>I>II &III) 46 Li 2010, 34 Eyibilen 2011, 36 Katainen 2015 (sec & serum) 45 none Eyibilen 2011 36 Li 2010 34 MMP-9/TIMP-2 Katainen 2015 (sec) 45 Katainen...…”

Section: Mmp-9mentioning

confidence: 99%

Matrix metalloproteinases and chronic rhinosinusitis with nasal polyposis. Unravelling a puzzle through a systematic review

Lygeros

Danielides

Grafanaki

et al. 2021

Rhin

View full text Add to dashboard Cite

BACKGROUND: The expression of metalloproteinases (MMPs) in chronic rhinosinusitis with nasal polyposis (CRSwNP) was reviewed in order to investigate their possible use as therapeutical targets and/or biomarkers. METHODOLOGY: The differences between CRSwNP and normal controls or CRS without NP, as well as the effects of various treatments on MMPs, tissue inhibitors of MMPs (TIMPs) and MMP/TIMP ratios were considered as primary outcomes. Additional factors reported to affect MMP expression levels were noted as secondary outcomes. Data regarding inflammatory subtypes, patients’ clinical characteristics, controls, laboratory method(s) and origin of samples were also pooled. Studies on 10 or fewer patients or on specimens other than nasal and serum were excluded. RESULTS: Forty-three studies were included. Tissue sample origin, allergic rhinitis, smoking, infection, medication intake and primary or recurrent disease should be considered as confounding factors for MMP levels. MMP-1 and -7 were consistently found to be significantly higher in CRSwNP patients than controls. CRSwNP endotypes with distinctly different inflammation patterns seem to present similar MMP-related remodelling patterns. CONCLUSIONS: The existing literature has revealed several population and methodology related confounding factors and remains inconclusive regarding the roles of MMPs in CRSwNP pathophysiology and their possible clinical usefulness as biomarkers and therapeutical targets.

show abstract

Immunopathologic Characteristics of Nasal Polyps in Adult Koreans: A Single-Center Study

Abstract: The immunopathologic characteristics differed between eosinophilic NP and noneosinophilic NP and between atopic NP and nonatopic NP. The different underlying pathogenic processes may influence the development of Korean NP.

Cited by 9 publications

References 19 publications

Differential Expression of Extracellular Matrix Components in Nasal Polyp Endotypes

Differential Expression of Extracellular Matrix Components in Nasal Polyp Endotypes

Pathological and therapeutic implications of eosinophil-derived semaphorin 4D in eosinophilic chronic rhinosinusitis

Matrix metalloproteinases and chronic rhinosinusitis with nasal polyposis. Unravelling a puzzle through a systematic review

Contact Info

Product

Resources

About