Immunopathological effects of experimental T-2 mycotoxicosis in Wistar rats

Rahman, Shafiqur; Sharma, Anil Kumar; Singh, Namita; Prawez, Shahid

doi:10.1177/0960327120968852

Cited by 5 publications

(7 citation statements)

References 36 publications

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“…What is more, the presence of karyomegaly and binucleation in epithelial cells was observed. The mononuclear cell infiltration around glomeruli and in the interstitium was also recorded in rats [57].…”

Section: Nephrotoxicitymentioning

confidence: 89%

“…Rahman and colleagues [57] showed the immunopathological effects of T-2 mycotoxicosis in rats. T-2 toxicity caused the suppression of both humoral and cellular immune responses in a dose and duration-dependent manner.…”

Section: Immunotoxicitymentioning

confidence: 99%

“…The depletion of lymphocytes started as single-cell apoptosis, then forming large foci of lymphocytolysis, especially in the thymus. Changes in thymus also included inter and intrafollicular hemorrhage and increased interfollicular connective tissue, resulting in early atrophy of thymic follicles [57].…”

Section: Immunotoxicitymentioning

confidence: 99%

See 2 more Smart Citations

T-2 Toxin—The Most Toxic Trichothecene Mycotoxin: Metabolism, Toxicity, and Decontamination Strategies

et al. 2021

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Among trichothecenes, T-2 toxin is the most toxic fungal secondary metabolite produced by different Fusarium species. Moreover, T-2 is the most common cause of poisoning that results from the consumption of contaminated cereal-based food and feed reported among humans and animals. The food and feed most contaminated with T-2 toxin is made from wheat, barley, rye, oats, and maize. After exposition or ingestion, T-2 is immediately absorbed from the alimentary tract or through the respiratory mucosal membranes and transported to the liver as a primary organ responsible for toxin's metabolism. Depending on the age, way of exposure, and dosage, intoxication manifests by vomiting, feed refusal, stomach necrosis, and skin irritation, which is rarely observed in case of mycotoxins intoxication. In order to eliminate T-2 toxin, various decontamination techniques have been found to mitigate the concentration of T-2 toxin in agricultural commodities. However, it is believed that 100% degradation of this toxin could be not possible. In this review, T-2 toxin toxicity, metabolism, and decontamination strategies are presented and discussed.

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Section: Nephrotoxicitymentioning

confidence: 89%

Section: Immunotoxicitymentioning

confidence: 99%

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T-2 Toxin—The Most Toxic Trichothecene Mycotoxin: Metabolism, Toxicity, and Decontamination Strategies

et al. 2021

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“…The T-2 toxin is one of the most common mycotoxins in agriculture and the environment. Excessive exposure to the T-2 toxin damages the immune, hematopoietic, reproductive, and nervous systems, posing a great threat to human health and the breeding industry. According to European Food Safety Authority investigations, most animals experience adverse effects at the dose of 0.1–2 mg/kg BW T-2 toxin exposure .…”

Section: Discussionmentioning

confidence: 99%

Selenium Improves Bone Microenvironment-Related Hematopoiesis and Immunity in T-2 Toxin-Exposed Mice

Zhang

Han²,

Song

et al. 2023

J. Agric. Food Chem.

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The T-2 toxin is one of the most frequent contaminants in the environment and agricultural production globally. It exerts a wide range of toxic effects. Selenium (Se), as an antioxidant, has the potential to be widely used to antagonize mycotoxin toxicity. To investigate the protective effects of Se on bone microenvironment (BM)-related hematopoiesis and immunity after T-2 toxin exposure, 36 male mice were treated with the T-2 toxin (1 mg/kg) and/or Se (0.2 mg/kg) by intragastric administration for 28 days. The results showed that Se alleviated T-2 toxin-induced cytopenia and splenic extramedullary hematopoiesis. Se also significantly relieved T-2 toxin-induced immunosuppression, as assessed by immune factors and lymphocytes. Furthermore, Se also attenuated oxidative stress and apoptosis and improved the BM in T-2 toxin-exposed mice. Therefore, Se improves BM-related hematopoiesis and immunity after T-2 toxin exposure. This study provides references for identifying the toxic mechanism and screening potential therapeutic drugs of the T-2 toxin.

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“…At the same time, under the toxic compounds, namely mycotoxins, a decrease in this indicator was observed, which may indicate a decrease in the synthesizing function of lymphatic cells (Rahman et al, 2021). The level of IgG in the blood serum of animals of Group 2 decreased, and during the experiment and up to Day 10 of research, compared to the background indicator, was 1.05 times lower, up to Day 30 -1.1 times, up to Day 60 -1.23 times, up to Day 125 -1.25 times.…”

Section: Immunoglobulins and Their Correction In Cows With Mycotoxico...mentioning

confidence: 96%

Indicators of Immunity in Associated Mycotoxicosis of Cows

Chekan¹,

Шкромада²,

Фотіна³

et al. 2022

Scientific Horizons

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The issue of cattle reproduction was and still is one of the main tasks in cattle breeding. Losses of farms from infertility of cows are quite significant and range within 3.19-5.41 per 1 day of infertility. Mycotoxins produced by fungi of the Fusarium family, namely deoxynivalenol (DON) and zearalenone (ZEN) adversely affect not only the functioning of all organs and systems of the cow’s body, but also produce an immunosedative effect. The purpose of this study was to establish the effect of the DON and ZEN complex on the main indicators of the immune response of cows and its correction in a comparative aspect using a feed additive based on zeolite and organic acids and recombinant α-, g-interferons. The study material was the blood of cows (serum and stabilized) sick with mycotoxicosis caused by the association of DON and ZEN. Methods used: photonephelometric using E. coli test culture, spontaneous rosette formation with sheep red blood cells according to M. Jondal, modified method of rosette formation according to M. Wansbrough-Jones, R. Limatibul’s method, simple radial immunodiffusion in gel according to G. Mancini, precipitation in a polyethylene glycol solution according to M. Digeon. Experimental studies were performed on black-spotted cows in farms of the Sumy Oblast. The dynamics of the immune indicators of cows during the development of mycotoxicosis and upon treatment with products zeolite-based, organic acids, and an aqueous solution of recombinant α-, g-interferons were studied. It was found that the indicator of bactericidal, lysozyme, complementary, and phagocytic activity of cow blood serum under treatment increased to the indicator inherent in healthy animals. The dynamics of immunoglobulins in the treatment with zeolite and organic acids and recombinant α-, g-interferons was investigated, and an increase to the level of intact cows was established. It was proved that the indicators of the immune response of cows upon using a feed additive based on zeolite and organic acids at a dose of 2.5 kg per tonne of fodder and a preparation based on an aqueous solution of recombinant α-, g-interferons at a dose of 3 ml per animal were significantly higher

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Immunopathological effects of experimental T-2 mycotoxicosis in Wistar rats

Cited by 5 publications

References 36 publications

T-2 Toxin—The Most Toxic Trichothecene Mycotoxin: Metabolism, Toxicity, and Decontamination Strategies

T-2 Toxin—The Most Toxic Trichothecene Mycotoxin: Metabolism, Toxicity, and Decontamination Strategies

Selenium Improves Bone Microenvironment-Related Hematopoiesis and Immunity in T-2 Toxin-Exposed Mice

Indicators of Immunity in Associated Mycotoxicosis of Cows

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