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It is well known that T-2 toxin has cytotoxic radiomimetic like effects on the immune system. Because of scant research data demonstrating the chronic effects of low doses of the T-2 toxin on humoral and cellular responses in rats, the present experiment was undertaken. The animals were divided into four groups, namely, group I (0.5 ppm), group II (0.75 ppm) and group III (1.0 ppm) and group IV (control) were given toxin-free diet for 12 weeks and eight animals each were sacrificed at 2, 4, 6, 8, 10, and 12-week of the experimental period. The humoral immune response was evaluated based on hemagglutination test (HA), and levels of serum immunoglobulins (IgA, IgG, IgM) while the cell-mediated immune response was evaluated by delayed-type hypersensitivity (DTH) response to ovalbumin, lymphocyte stimulation index, analyses of CD4+ and CD8+ T lymphocytes and mRNA expression levels of selected cytokines like IL-2, IFN-γ, IL-4 and IL-10 by quantitative Real-time PCR in experimental groups. T-2 treatment caused suppression in both humoral and cell-mediated immune responses as evidenced by a decrease in all these parameters in toxin fed animals compared to the control in the dose and duration-dependent manner. This dose-dependent effect on the immune system has been further reflected largely by the depletion of lymphocytes from lymphoid organs as observed histopathologically in the spleen, thymus, and Peyer’s patches in the present study.

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A 20 years old man presented with 4 year history of painless swelling of the left testis. He ignored this swelling until he started having pain in the abdomen. Ultrasonography revealed testicular malignancy with multiple para-aortic lymph nodes enlargements in the abdomen. His X-ray chest showed pulmonary metastasis. One tumor marker was raised. Histology revealed mixed germ cell tumour with a rare combination of seminoma and embryonal carcinoma. Because of this rare combination of 2 varieties of testicular germ cell tumor and extensive systemic metastasis we presented this case. We discussed the epidemiology, incidence, classification, staging, treatment and prognosis of testicular cancer.Anwer Khan Modern Medical College Journal Vol. 6, No. 1: January 2015, Pages 50-54