Immunopathology of intraocular silicone oil: enucleated eyes

Wickham, Louisa; Asaria, Riaz; Alexander, Robert; Luthert, Philip J.; Charteris, David G.

doi:10.1136/bjo.2006.103564

Cited by 70 publications

(57 citation statements)

References 22 publications

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“…25 It was thought that a foreign body reaction to heavy tamponades triggers an increased inflammatory response, leading to an increased membrane formation with the consequences of re-detachment, recurrent PVR, and cyclitic membranes. In fact, such changes can be seen following unsuccessful surgery with conventional silicone oil, 26 and similar changes are likely to occur with heavy silicone oil. Whether or not the heavy tamponade, a part of the recently developed heavy silicone oils, adds an additional immunogenic factor is unknown at present.…”

Section: Discussionmentioning

confidence: 93%

Clinical complications of Densiron 68 intraocular tamponade for complicated retinal detachment

Zheng

et al. 2009

Eye

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Purpose To report and disscuss the postoperative complications in patients after Densiron 68 intraocular tamponade in the management of complicated retinal detachment with proliferative vitreoretinopathy (PVR). Methods We presented a prospective interventional non-comparative case series of 27 eyes of 27 consecutive patients. Inclusion criteria were PVR, posterior or inferior retinal breaks, and the patient's inability to posture. Vitreoretinal surgery with Densiron 68 intraocular tamponade was performed in all patients. Complications were recorded at 1 week and 1, 2, and 3 months after Densiron 68 intraocular tamponade and after removal of Densiron 68 endotamponade at same periods. Results The most common complication was posterior capsule opacification and cataract development in seven eyes (25.9%) and in two eyes (25%, 2/8), respectively, the second complication was intraocular inflammation in six eyes (22.2%), the third complication was emulsification and dispersion and raised intraocular pressure in five eyes (18.5%), respectively. The success rate with one operation using Densiron 68 was 85.2% and with further surgery 92.5%. Visual acuity improved from mean logMAR of 2.12 (SD ¼ 0.68) to 1.16 (SD ¼ 0.84), P ¼ 0.0001. Conclusions According to the results of this study, postoperative complications did not increase significantly in the vitreoretinal surgery with temporary Densiron 68 intraocular tamponade. Densiron 68 intraocular tamponade is safe and effective in treating complicated retinal detachment.

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Section: Discussionmentioning

confidence: 93%

Clinical complications of Densiron 68 intraocular tamponade for complicated retinal detachment

Zheng

et al. 2009

Eye

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“…13 It was thought that a foreign body reaction to heavy tamponades triggers an increased inflammatory response, leading to an increased membrane formation with the consequences of redetachment, recurrent PVR, and cyclitic membranes. In fact, such changes can be seen following unsuccessful surgery with conventional silicone oil, 60 and similar changes are likely to occur with heavy silicone oil. Whether or not the heavy tamponade part of the recently developed heavy silicone oils adds an additional immunogenic factor is unknown at present.…”

Section: Ocular Hypotensionmentioning

confidence: 93%

Heavy tamponade 1: a review of indications, use, and complications

Heimann

Stappler

Wong

2008

Eye

117

125

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Background Heavier than water intraocular tamponades have several theoretical advantages over conventional tamponades, especially in the treatment of complicated retinal detachments and proliferative viteroretinopathy of the lower fundus periphery. However, initial clinical series of various heavy tamponades have reported significant complication rates. Therefore, heavy tamponades have not found widespread acceptance. Three recently developed heavy silicone oil tamponades, Oxane HD, Densiron 68, and HWS 46-3000, are much better tolerated and presently seem to enter routine clinical practice. Materials and methods Literature review of 21 publications on the clinical application of 9 different heavy tamponades (fluorosilicone, C10F18, F6H8, OL62HV, Oxane HD, O62, F6H8-silicone oil mixture, Densiron 68, and HWS 46-3000). Results The first generation (fluorinated silicone and perfluorocarbon liquids) and second generation (partially fluorinated alkanes) of heavy tamponades were associated with relatively high complication rates, for example, tamponade emulsification, intraocular inflammation, and rise in intraocular pressure. The complication spectrum of the new generation of heavy silicone oils (Oxane HD, Densiron 68, and HWS 46-3000) seems to be comparable to conventional silicone oil tamponades while providing better support for the inferior retina and the posterior pole. Conclusion The recently developed heavy silicone oil tamponades are safe and effective tools for the use of complicated retinal detachments of the inferior fundus.

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“…It has been shown that SO has toxic effects on many ocular structures, such as the optic nerve, retina, crystalline lens, trabecular meshwork, and cornea [1][2][3][4]. However, the possible effects of SO on the choroid are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Effects of Intravitreal Silicone Oil on Subfoveal Choroidal Thickness

et al. 2018

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Purpose: To evaluate the effects of intravitreal silicone oil (SO) on subfoveal choroidal thickness (SFCT). Methods: A total of 60 patients with unilateral pseudophakic macula-off rhegmatogenous retinal detachment were treated with a three-port pars plana vitrectomy and a 5,700-cSt SO endotamponade and subsequent SO removal. SFCT was measured before and 3 months after SO removal. The main outcome measure was the difference between the SFCT of operated eyes and the fellow eyes. Results: Before SO removal, the mean SFCT differences in group 1 (3–6 months’ duration of SO), group 2 (6–9 months’ duration of SO), and group 3 (9–18 months’ duration of SO) were –14.8, –25.5, and –62.1 µm, respectively (p = 0.002, r = 0.398). Three months after SO removal, the mean SFCT differences in group 1, group 2, and group 3 were –13.4, –23.3, and –59.0 µm, respectively (p = 0.002, r = 0.393). Conclusion: SFCT decreased significantly in eyes with long-term (≥6 months) intravitreal SO tamponade. Choroidal thinning did not improve after SO removal.

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Immunopathology of intraocular silicone oil: enucleated eyes

Cited by 70 publications

References 22 publications

Clinical complications of Densiron 68 intraocular tamponade for complicated retinal detachment

Clinical complications of Densiron 68 intraocular tamponade for complicated retinal detachment

Heavy tamponade 1: a review of indications, use, and complications

Effects of Intravitreal Silicone Oil on Subfoveal Choroidal Thickness

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