Immunoperoxidase characterization of extramedullary plasmacytoma of the head and neck

Mock, Presley M.; Neal, G. David; Aufdemorte, Thomas B.

doi:10.1002/hed.2890090610

Cited by 24 publications

(15 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There may be destruction of adjacent bone in direct continuity with the tumour mass. Poole and Marchetta (1968), Gromer andDuvall (1973), Harwood et al (1981) and Mock et al (1987) felt that the presence of bone destruction seemed to be an unfavourable prognostic factor, while Kotner and Wang (1972), Corwin and Lindberg (1979), Kapadia et al (1982) and Mayr et al (1990) were not of the same opinion. In our series, two of three tumours with bone destruction recurred locally; one of them was a solitary high-grade EMP, and the patient presented with a huge tumour in the paranasal sinuses (Figure 6).…”

Section: Bone Destructionmentioning

confidence: 99%

“…The monoclonal gammopathy disappears following treatment of localized primary tumour. Subsequent development of a paraprotein may signal a recurrence (Kapadia et al, 1982;Mock et al, 1987). Holland et al (1992) felt that patients with paraprotein at the time of diagnosis fared worst, while Harwood et al (1981), Soesan et al (1992) and Shih et al (1995) suggested no effect on prognosis provided they return to normal after treatment.…”

Section: Diagnostic Criteriamentioning

confidence: 99%

“…This leaves us with the question of whether the higher grade tumours should be treated differently in terms of either XRT dose and volume or the use of adjuvant chemotherapy. Mock et al (1987), in a retrospective analysis of 18 cases of EMP of the head and neck, found that the commonest immunoglobulin was IgG with kappa light chain restriction. They observed the lowest rate of progression to MM with IgG, and none of the cases with kappa light chain restriction progressed to MM.…”

Section: Pathologymentioning

confidence: 99%

“…One of them is in remission and the second patient died with uncontrolled disease after receiving palliative XRT. Several studies suggest that the presence of involved cervical nodes at diagnosis or subsequent development does not affect the survival or conversion to MM (Poole and Marchetta, 1968;Kotner and Wang, 1972;Corwin and Lindberg, 1979;Mock et al, 1987). Some authors recommend prophylactic cervical lymph nodal XRT as it was the first site of relapse in their patients (Knowling et al, 1983;Greenberg et al, 1987;Mayr et al, 1990;Shih et al, 1995).…”

Section: Pathologymentioning

confidence: 99%

See 3 more Smart Citations

Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases

Susnerwala

Shanks²,

Banerjee³

et al. 1997

Br J Cancer

188

195

View full text Add to dashboard Cite

Summary Extramedullary plasmacytomas (EMP) of head and neck are rare tumours. Between 1972 and 1993, 25 cases of EMP of head and neck were seen at our institute. The clinical and pathological features and response to treatment are presented. At initial presentation, 23 (92%) patients presented with disease confined to a single extramedullary site only and two patients had in addition clinical involvement of cervical lymph nodes. All except these two patients received radiotherapy to the primary site only as initial treatment. Initial primary control of local disease was obtained in 16 of 24 (67%) patients treated with radical intent. With salvage treatment of further radiotherapy and/or chemotherapy, local disease control was achieved in 21 of 24 (88%) patients. One patient was treated with palliative intent. Conversion to multiple myeloma was seen in two patients (8%). Pathologically, the tumours were classified into low, intermediate and high grade, which correlated closely with outcome. This classification has been used for the first time in extramedullary plasmacytomas and is based on the multiple myeloma grading criteria devised by Bartl et al (1987). Fifteen of eighteen (83%) low-grade tumours and only one of six (17%) intermediate-and high-grade tumours were locally controlled after primary radiotherapy. This is statistically significant for local control (P= 0.0019) but not for overall survival (P= 0.12). The median survival and 5-year overall survival is 68 months and 58.9% respectively. We recommend consideration of adjuvant chemotherapy in patients with higher grade disease.

show abstract

Section: Bone Destructionmentioning

confidence: 99%

Section: Diagnostic Criteriamentioning

confidence: 99%

Section: Pathologymentioning

confidence: 99%

Section: Pathologymentioning

confidence: 99%

See 2 more Smart Citations

Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases

Susnerwala

Shanks²,

Banerjee³

et al. 1997

Br J Cancer

188

195

View full text Add to dashboard Cite

show abstract

“…Immunohistochemical characterization of human EMP with immunoglobulin heavy and light chains reveals a monoclonal proliferation of plas-ma cells that secrete a single immunoglobulin type with both λ and K light chains equally represented. 18,19 Previous studies of canine EMP have used a variety of immunohistochemical markers for diagnostic purposes and have determined that canine EMPs are of plasma cell origin. 1,13,20,24 The neoplastic nature of the tumors was confirmed by the identification of a monoclonal expression of immunoglobulin light chains.…”

mentioning

confidence: 99%

Identification of Immunoglobulin Light Chains in Canine Extramedullary Plasmacytomas by Thioflavine T and Immunohistochemistry

Brunnert

Altman

1991

J VET Diagn Invest

View full text Add to dashboard Cite

Abstract. Extramedullary plasmacytomas were studied in 29 dogs. The site at which tumors occurred and the age and sex of the dogs were similar to those in previous reports. The skin of the digits, chin, ear, and lip represented the most common (17/29) tumor sites. Males and females were equally represented, and tumors occurred in middle-aged to old dogs (mean age, 9.0 years). A breed predilection was seen in the Cocker Spaniel (n = 7; 24%); Cocker Spaniels represented only 4% (210/4,725) of the submissions during the same period. Tumors were stained with immunohistochemical markers (λ light chain, K light chain) and thioflavine T. Immunoreactivity was limited to either λ or K light chains, consistent with a monoclonal plasma cell population. The majority of tumors expressed λ light chains, consistent with previously reported canine plasma cell dyscrasias. Thioflavine T cytoplasmic fluorescence was seen in the majority (18/29) of plasmacytomas and with inflammatory plasma cells present in control specimens. Other round cell neoplasms (lymphosarcoma, histiocytoma, and mastocytoma) were negative with thioflavine T, indicating that positive staining with thioflavine T was specific for plasma cells (neoplastic and inflammatory). This study confirms by immunohistochemistry that canine extramedullary plasmacytomas disproportionately express λ light chains and establishes thioflavine T staining as a rapid histochemical method for diagnosis of these tumors.The morphologic, clinical, and biological features of canine extramedullary plasmacytoma (EMP) have been reported 1,13,16,17,20,24 Most dogs were aged adults, and tumors developed most commonly on the mucocutaneous junction of the mouth, the skin between the digits, and on the external ear. 1,24 More than 90% of the dogs with cutaneous EMP were cured by surgical excision, indicating that these tumors were most likely benign. Multiple EMP were found in a small percentage of dogs but were not associated with progression to multiple myeloma. Only rarely did cases of canine EMP precede the development of multiple myeloma, 14,24 which is different from the clinical course seen in humans.In humans, long-term survival of 15 years without recurrence occurs in the majority of cases of EMP, 28 but in approximately 25% of the cases, EMP will develop into multiple myeloma. 18 When EMP precedes the development of multiple myeloma, an extended period (up to 10 years) may occur before clinical signs of bone involvement are noted. Secondary extramedullary involvement of the skin with primary multiple myeloma is rare. Immunohistochemical characterization of human EMP with immunoglobulin heavy and light chains reveals a monoclonal proliferation of plas-

show abstract

Extramedullary plasmacytoma

Alexiou

Kau

Dietzfelbinger

et al. 1999

Cancer

490

191

View full text Add to dashboard Cite

Immunoperoxidase characterization of extramedullary plasmacytoma of the head and neck

Cited by 24 publications

References 7 publications

Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases

Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases

Identification of Immunoglobulin Light Chains in Canine Extramedullary Plasmacytomas by Thioflavine T and Immunohistochemistry

Extramedullary plasmacytoma

Contact Info

Product

Resources

About