Immunoperoxidase localization of keratin proteins, carcinoembryonic antigen, and factor VIII in adenomatoid tumors

Said, Jonathan W.; Nash, Gerald D.; Lee, Melinda

doi:10.1016/s0046-8177(82)80247-5

Cited by 51 publications

(16 citation statements)

References 9 publications

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“…Mitotic figures were not seen. As illustrated in our case and supported by other studies involving adenomatoid tumors from both male and female genital tracts, the tumor exhibited positive immunostaining for cytokeratin and vimentin [7,12,13].…”

Section: Discussionsupporting

confidence: 90%

Adenomatoid tumor of the testis in a child

Liu

2011

Journal of Pediatric Surgery

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Section: Discussionsupporting

confidence: 90%

Adenomatoid tumor of the testis in a child

Liu

2011

Journal of Pediatric Surgery

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“…even question whether adenomatoid tumors are neoplastic or reactive lesions 2 . The origin of these tumors was debated for years, but more recent studies utilizing electron microscopy and immunohistochemical staining point toward a likely mesothelial origin 3–6 . The great majority of tumors in men are found in the epididymis with only rare case reports in the spermatic cord, tunica albuginea and in the testicular parenchyma 1,2 , 6,7 .…”

Section: Discussionmentioning

confidence: 99%

Adenomatoid tumor of the tunica albuginea

et al. 2005

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Adenomatoid tumors are benign mesothelial tumors most commonly found in the paratesticular structures, especially the epididymis. Herein, we report a case of adenomatoid tumor originating in the tunica albuginea and mimicking an intratesticular neoplasm. We review the ultrasonographic presentation and literature regarding adenomatoid tumors originating in the tunica albuginea and testicular parenchyma.Key words adenomatoid, case report, review, testes, tumor, tunica albuginea. Case reportA 44-year-old African-American male presented with a 1 year history of a right midtesticular mass which had progressively enlarged over the last 3 months. He denied having any urinary or constitutional symptoms. On physical examination, his testicles were descended bilaterally with a nodule noted in the midposterior aspect of the right testicle. His physical examination was otherwise unremarkable. Serum tumor markers including b -human chorionic gonadotropin, a -fetoprotein and lactate dehydrogenase were normal. Scrotal ultrasonography was performed, revealing a right testicular mass (Fig. 1).The patient underwent exploration via a right inguinal approach. After isolating the spermatic cord, an excisional biopsy was sent for intraoperative frozen section analysis (Fig. 2). These sections were suggestive of an epithelial neoplasm, though malignancy could not be excluded. A right radical orchiectomy with high ligation of the cord was therefore performed. Final pathological analysis showed mesothelioid cell invasion from the tunica albuginea into the testicular parenchyma. The tumor cells were positive for CK7 and tumor cell nuclei stained darkly with calretinin (typical of mesotheloid subtype adenomatoid tumors). The tumor itself measured 0.7 ¥ 0.6 ¥ 0.5 cm with clear margins (Figs 3,4).

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“…Immunohistochemical studies have, to date, provided some evidence for the tissue of origin for adenomatoid tumour, although the results are supportive rather than definitive in determining that the tumour is of mesothelial origin. In common with benign mesothelial cells and the epithelial cells from malignant mesothelioma, adenomatoid tumour from both male and female genital tracts have been shown to exhibit positive immunostaining for pan‐cytokeratin and vimentin 9 , 18 , 19 . Lack of a variety of carcinoma‐related antigens (Ber‐EP4, Leu M1, AUA‐1, CEA, CA 19.9 and HEA‐125) has also been found to be of assistance in the diagnosis of mesothelioma by excluding tumours of similar morphology but different pathogenesis 20 –22 .…”

Section: Discussionmentioning

confidence: 99%