Immunophenotypic characterization of double positive T lymphocytes in Cuban older adults

Marrero, Yenisey Triana; Súarez, Vianed Marsán; Abraham, Consuelo Milagros Macías; Hernández, Imilla Casado; Ramos, Elizabeth Hernández; Domínguez, Gabriela Díaz; Pérez, Yaneisy Duarte; Zamora, Mary Carmen Reyes; Guerra, Luis Felipe Heredia

doi:10.1016/j.exger.2021.111450

Cited by 7 publications

(5 citation statements)

References 12 publications

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“…As already mentioned, DP T cells are increased in the blood of healthy older adults compared to young ones [15], and it has been observed that older adults with higher DP T cell numbers had some associated comorbidities [57]. DP T cell populations are altered in different ailments, namely (1) infectious diseases, (2) inflammatory/autoimmune diseases, and (3) cancer.…”

Section: Peripheral Cd4 + Cd8 + Double-positive T Cells In Diseasementioning

confidence: 95%

Legend or Truth: Mature CD4+CD8+ Double-Positive T Cells in the Periphery in Health and Disease

Hagen,

Pangrazzi,

Rocamora-Reverte

et al. 2023

Biomedicines

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The expression of CD4 and CD8 co-receptors defines two distinct T cell populations with specialized functions. While CD4+ T cells support and modulate immune responses through different T-helper (Th) and regulatory subtypes, CD8+ T cells eliminate cells that might threaten the organism, for example, virus-infected or tumor cells. However, a paradoxical population of CD4+CD8+ double-positive (DP) T cells challenging this paradigm has been found in the peripheral blood. This subset has been observed in healthy as well as pathological conditions, suggesting unique and well-defined functions. Furthermore, DP T cells express activation markers and exhibit memory-like features, displaying an effector memory (EM) and central memory (CM) phenotype. A subset expressing high CD4 (CD4bright+) and intermediate CD8 (CD8dim+) levels and a population of CD8bright+CD4dim+ T cells have been identified within DP T cells, suggesting that this small subpopulation may be heterogeneous. This review summarizes the current literature on DP T cells in humans in health and diseases. In addition, we point out that strategies to better characterize this minor T cell subset’s role in regulating immune responses are necessary.

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Section: Peripheral Cd4 + Cd8 + Double-positive T Cells In Diseasementioning

confidence: 95%

Legend or Truth: Mature CD4+CD8+ Double-Positive T Cells in the Periphery in Health and Disease

Hagen,

Pangrazzi,

Rocamora-Reverte

et al. 2023

Biomedicines

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show abstract

“…In this sense, the establishment of the thymic microenvironment could contribute to the preservation or restoration of immune protection and enhance the quality of the immune response against infections and cancer. [28] A recent article published showed that most of the Cuban older adults evaluated who exhibited high percentage and absolute values of TDP lymphocytes, had some associated comorbidity, among them infections and cancer [29]. This supports the claimed idea about its role as an immunosuppressant or potentially cytotoxic cell.…”

Section: Discussionmentioning

confidence: 65%

BIOMODULINA T® Modulates Lymphocyte Compartments in Institutionalized Cuban Geriatric Patients

2022

Journal of Cellular Immunology

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BIOMODULINA T® is a biological immunomodulator of natural origin, not blood derived, which promises to be a strategy for immune restoration in the elderly, in the midst of the worldwide epidemiological crisis due to the SARS-CoV-2 virus. This research aimed to determine the changes induced by BT in the distribution of lymphocyte compartments of institutionalized Cuban geriatric patients. The significant expansion of the naïve CD4 + and CD8 + , CD19 + , NK T cells and of the CD3 + HLA-DR + and CD3 + CD25 + activation populations was observed; while the rest of the populations of T, B compartments, the T population that co-express CD4 and CD8, and the CD4-CD8-TCRαβ + T cells did not show significant changes. BT had an effect on the immune restoration of T and B lymphocyte populations of Cuban older adults. It modulates the immune response and inflammation, restores immunity, and can contribute to a strategy to prevent and treat COVID-19 in elderly.

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“…They are increased in the elderly, in neoplasms such as melanoma and in auto-immune diseases. 18 , 19 , 20 So, the DP T cells could have a cytotoxic or immunomodulating effect that could contribute to TFR maintenance. So, the DP T cells could have a cytotoxic or immunomodulating effect that could contribute to TFR maintenance but, to the best of our knowledge, this has not yet been examined in CML.…”

Section: Discussionmentioning

confidence: 99%

Peripheral lymphocyte subsets as predicting factors for molecular recurrence after imatinib discontinuation in a phase 2 imatinib discontinuation trial in patients with chronic myeloid leukemia

Braga,

Barbosa Pagnano,

Campioni

et al. 2024

Hematology, Transfusion and Cell Therapy

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Immunophenotypic characterization of double positive T lymphocytes in Cuban older adults

Cited by 7 publications

References 12 publications

Legend or Truth: Mature CD4+CD8+ Double-Positive T Cells in the Periphery in Health and Disease

Legend or Truth: Mature CD4+CD8+ Double-Positive T Cells in the Periphery in Health and Disease

BIOMODULINA T® Modulates Lymphocyte Compartments in Institutionalized Cuban Geriatric Patients

Peripheral lymphocyte subsets as predicting factors for molecular recurrence after imatinib discontinuation in a phase 2 imatinib discontinuation trial in patients with chronic myeloid leukemia

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