Immunoreactive renin concentrations in healthy children from birth to adolescence

Krüger, Carsten; Rauh, Manfred; Dörr, Helmuth G.

doi:10.1016/s0009-8981(98)00044-8

Cited by 35 publications

(17 citation statements)

References 46 publications

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“…The data that are available indicate that plasma renin concentrations and/or activity are typically quite high in infancy, particularly in premature infants, with a direct correlation to gestational age [107][108][109]. Although renal artery stenosis and thromboembolism are typically considered high renin states, peripheral plasma renin activity may not be elevated in such infants despite the presence of significant underlying pathology.…”

Section: Diagnostic Evaluationmentioning

confidence: 99%

Hypertension in infancy: diagnosis, management and outcome

2011

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Advances in the ability to identify, evaluate, and care for infants with hypertension, coupled with advances in the practice of Neonatology, have led to an increased awareness of hypertension in modern neonatal intensive care units. This review will present updated data on blood pressure values in neonates, with a focus on the changes that occur over the first days and weeks of life in both term and preterm infants. Optimal blood pressure measurement techniques as well as the differential diagnosis of hypertension in the neonate and older infants will be discussed. Recommendations for the optimal immediate and long-term evaluation and treatment, including potential treatment parameters, will be presented. We will also review additional information on outcome that has become available over the past decade.

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Section: Diagnostic Evaluationmentioning

confidence: 99%

Hypertension in infancy: diagnosis, management and outcome

2011

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“…To estimate the influence of metabolic control at the time of BP assessment, we made correlation analyses between serum renin, serum 17-OHP, morning saliva 17-OHP, 24-h urine pregnanetriol, 24-h urine pregnanetriol to tetrahydrocortisone ratio (only in patients with hydrocortisone), and the BA delay (BA minus CA in years) and all BP and HR variables: there was no correlation regarding any of these parameters (Table 1). There was no significant difference between the patients with either low (Ͻfifth percentile, n ϭ 9) or elevated (Ͼ95th percentile, n ϭ 9) serum renin concentrations according to age-specific reference values (26) in any BP variable.…”

Section: Medication and Metabolic Controlmentioning

confidence: 88%

Altered 24-Hour Blood Pressure Profiles in Children and Adolescents with Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

Völkl¹,

Simm²,

Dötsch

et al. 2006

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…Major signs of poor metabolic control were progressive virilization, intervals of Ͼ6 months (Ͻ12 years of age) or Ͼ12 months (Ͼ12 years of age) between visits at our outpatient endocrine unit, increased urinary excretion of pregnanetriol, exceeding the reference limits published by Knorr and Hinrichsen-de-Lienau, 3 or height velocity SDS of Ͼ2.0; minor signs of poor metabolic control were height velocity SDS of Ͼ2 but decreasing, change in bone age relative to change in chronologic age of Ͼ1.5 (prepubertal) or Ͼ2.5 (pubertal), serum 17-hydroxyprogesterone concentrations of Ͼ10 g/L, or serum renin concentrations above the 95% confidence interval. 11,12 Major signs of overtreatment were Cushing signs, maintained or progressive, height velocity SDS less than Ϫ2 and decreasing, or urinary excretion of pregnanetriol below the reference limits; minor signs were height velocity SDS less than Ϫ2, maintained or increasing, serum 17-hydroxyprogesterone concentrations of Ͻ0.1 g/L, or serum renin concentrations below the 5% confidence interval. Urinary creatinine levels were also measured, to assess collection completeness.…”

Section: Patientsmentioning

confidence: 99%

Obesity Among Children and Adolescents With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency

et al. 2006

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OBJECTIVES. Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is the most common inherited disorder of adrenal steroid biosynthesis. Patients with the classic form of CAH show androgen excess, with or without salt wasting. There are few studies reporting on higher rates of overweight and obesity among children with CAH. In addition to its role in the regulation of energy balance, leptin is involved in various endocrine and metabolic pathways. In this context, elevated serum leptin levels were reported recently for patients with CAH and were thought to be involved in the development of obesity among these patients. Therefore, the aim of this study was to analyze BMI values, compared with population-based references, for children and adolescents with CAH. Possible contributing factors, such as glucocorticoid therapy, skeletal maturation, birth weight and length, and parental BMI, were correlated with current BMI SD scores (SDS). In addition, the implications of serum leptin levels, corrected for BMI, gender, and Tanner stage, were investigated.METHODS. We performed a cross-sectional retrospective study of 89 children and adolescents with CAH (48 female and 41 male subjects; age: 0.2-17.9 years) who presented in our outpatient department during 1 year. All individuals had classic CAH, confirmed with molecular genetic analyses, and received substitution therapy (glucocorticoids and mineralocorticoids, if necessary). The quality of therapy was monitored in follow-up visits every 3 to 6 months, on the basis of clinical presentation and laboratory measurement findings according to current guidelines. We grouped the patients into salt wasting and simple virilizing groups, as well as according to current metabolic control. Leptin levels were measured with a commercial radioimmunoassay and calculated as SDS. For statistical analyses, standard parametric and nonparametric methods were used.RESULTS. The chronologic ages of the children with CAH were between 0.20 and 17.9 years (mean Ϯ SD: 8.9 Ϯ 4.6 years). The BMI SDS of the whole group ranged from Ϫ2.7 to 4.3 (mean Ϯ SD: 0.88 Ϯ 1.3) and was significantly elevated above 0.www.pediatrics.org/cgi

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Immunoreactive renin concentrations in healthy children from birth to adolescence

Cited by 35 publications

References 46 publications

Hypertension in infancy: diagnosis, management and outcome

Hypertension in infancy: diagnosis, management and outcome

Altered 24-Hour Blood Pressure Profiles in Children and Adolescents with Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

Obesity Among Children and Adolescents With Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency

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