Immunoreactive somatomedin C in children from Morocco: a biological marker of nutritional growth retardation ?

Bouhaddioui, L.; Brun, Jean-Frédéric; Jacquemin, J. L.; Bailly, A; Bouhaddioui, N; Kabbaj, Karima; Orsetti, A

doi:10.1016/0753-3322(89)90192-3

Cited by 12 publications

(6 citation statements)

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“…Somatomedins play an important role for growth in general. SmC is significantly lower in short children than in age-matched children of normal height (Sanayama et al, 1987;Suwa et al, 1988), and SmC is low in malnutrition (Bouhaddioui et al, 1989) and in growth-impaired children with chronic inflammatory bowel disease (Kirschner & Sutton, 1986). There is a close relationship between the growth spurt around puberty and SmC-levels (Rosenfield et al, 1983;Suwa et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

Somatomedin C (insulin‐like growth factor 1) in adults with Down's syndrome

Hestnes¹,

Stovner²,

Husøy³

et al. 1991

J intellect Disabil Res

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ABSTRACT. In a Norwegian institution for the mentally retarded, 29 adults with chromosomally verified Down's syndrome were compared to other mentally retarded patients with respect to serum somatomedin C (SmC) (insulin‐like growth factor 1 [IGF‐1]). Contrary to what has been observed in children, no shortage of SmC could be demonstrated in the adults with Down's syndrome. The results were within the normal range, and there was no difference between those with Down's syndrome and the other mentally retarded patients. Human growth hormone (HGH) and body height were studied in a previous work. Some correlations with these data are, nevertheless, included herein because they are of relevance. SmC correlated with body height in Down's syndrome, while there was no correlation between SmC and HGH or between HGH and body height.

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Section: Discussionmentioning

confidence: 99%

Somatomedin C (insulin‐like growth factor 1) in adults with Down's syndrome

Hestnes¹,

Stovner²,

Husøy³

et al. 1991

J intellect Disabil Res

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“…Serum levels of IGF-I and IGFBP-3 exhibit little diurnal variation (Jorgensen et al, 1990) and reflect endogenous GH secretion in healthy children (Blum et al, 1993). In addition to GH status, chronological age, gonadal maturation and nutrition also have influence on IGF-I concentration significantly (Bouhaddioui et al, 1989;Lopez-Jaramillo et al, 1992;Juul et al, 1994Juul et al, , 1995. It has been demonstrated that plasma IGF-I levels are lower in malnourished children (Unterman et al, 1985;Bouhaddioui et al, 1989;Wan Nazaimoon et al, 1996;Beaune et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

“…In addition to GH status, chronological age, gonadal maturation and nutrition also have influence on IGF-I concentration significantly (Bouhaddioui et al, 1989;Lopez-Jaramillo et al, 1992;Juul et al, 1994Juul et al, , 1995. It has been demonstrated that plasma IGF-I levels are lower in malnourished children (Unterman et al, 1985;Bouhaddioui et al, 1989;Wan Nazaimoon et al, 1996;Beaune et al, 1997). The role of the socioeconomic status on IGF-I, IGFBP-3 axis is suggested as a result of the effect of nutrition on IGF axis.…”

Section: Introductionmentioning

confidence: 99%

The effect of economic status on height, insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations in healthy Turkish children

et al. 2006

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Objectives: The effect of economic status (ES) on growth, insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-3 in healthy children is not well characterized. We aimed to study the interrelationship between height, weight, IGF-I, IGFBP-3, mid-parental height (MPH) and ES. Design/subjects: Eight hundred and fourteen healthy children (428 boys, 386 girls; age 3-18 years) were classified according to income of the families as low, middle and high. Standard deviation scores (SDSs) of height, weight, MPH, IGF-I and IGFBP-3 were compared between the groups. The combined effect of these parameters and ES on height SDS was investigated with complex statistical models. Results: There was a significant trend for height and weight SDSs to increase with higher income levels in boys, but not in girls. Body mass index (BMI) SDSs were similar in three groups. There was a general trend for MPH SDS to increase with income levels in both sexes. In boys, IGF-I SDS was significantly higher in high ES group than low ES. In girls, IGFBP-3 SDSs were significantly higher in high ES group than in middle ES group. For both genders, height SDS was highly correlated with weight SDS and moderately correlated with BMI SDS, MPH SDS and IGF-1 SDS. All correlations were significant and positive. Complex models showed that MPH (19%), IGF-I (13%) and ES (3%) in boys, and MPH (16%) and IGF-I (7%) in girls have significant contribution to height SDSs. Conclusions: ES per se, independent of overt malnutrition, affects height, weight, IGF-I and IGFBP-3 with some gender differences in healthy children. Influence of income on height and weight show sexual dimorphism, a slight but significant effect is observed only in boys. MPH is the most prominent variable effecting height in healthy children. Higher height and MPH SDSs observed in higher income groups suggest that secular trend in growth still exists, at least in boys, in a country of favorable economic development.

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“…The growth‐promoting effect of growth hormone (GH) is mediated, at least in part, via insulin‐like growth factor‐1 (IGF‐1). It has been demonstrated that plasma IGF‐1 levels are lower in malnourished children [15,16].…”

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confidence: 99%