Immunoreactivity for β/A4 protein, but not for its precursor, in human chromaffin cells

Alonso-Cortina, V.; Gonzalez-Vazquez, L.O.; Cabal, Álvaro Arias; Esteban, I.; Soto, Miguel; Ja, Vega

doi:10.1016/0361-9230(95)00022-7

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…10 TrkA was the only receptor found in chromaffin cells (50%), although a previous study in human adrenal gland showed TrkC, 48 using the same antibody as used here. Because TrkA was regularly present in a subpopulation of chromaffin cells 10,26,27 the partial discrepancies between present and previous studies could be related to differences in the methods used (RT-PCR, mRNA detection vs immunohistochemistry) or in the processing of the tissues.…”

Section: Discussioncontrasting

confidence: 77%

“…Moreover, adrenal chromaffin cells of man and rat express both TrkA and p75. 10,26,27 Nevertheless, whether human adrenal chromaffin cells express neurotrophins or receptors other than p75 LNGFR and TrkA, and whether this also occurs for other types of neural crest-derived cells, such as paraganglionic cells, is still unknown. On the other hand, there is no information available as to the occurrence of neurotrophins and/or their receptors in human neural crestderived tumours, except for neuroblastoma.…”

Section: Introductionmentioning

confidence: 99%

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Neurotrophins and neurotrophin receptors in some neural crest‐derived tumours (ganglioneuroma, phaeochromocytoma and paraganglioma)

et al. 1999

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Section: Discussioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Neurotrophins and neurotrophin receptors in some neural crest‐derived tumours (ganglioneuroma, phaeochromocytoma and paraganglioma)

et al. 1999

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S‐100 proteins in the human peripheral nervous system

González-Martínez

Pérez-Piñera

Díaz-Esnal

et al. 2003

Microscopy Res & Technique

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130

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This article reviews the distribution of S100 proteins in the human peripheral nervous system. The expression of S100 by peripheral glial cells seems to be a distinctive fact of these cells, independently of their localization and their ability to myelinate or not. S100 proteins expressing cells include satellite cells of sensory, sympathetic and enteric ganglia, supporting cells of the adrenal medulla, myelinating and non-myelinating Schwann cells in the nerve trunks, and the Schwann-related cells of sensory corpuscles. In addition, S100 proteins are expressed in peripheral neurons. Most of them express S100alpha protein, and a subpopulation of sensory neurons in dorsal root ganglia contains S100beta protein or S100alpha plus S100beta proteins.

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Changes of the Enteric Nervous System in Amyloid-β Protein Precursor Transgenic Mice Correlate with Disease Progression

Semar

Klotz

Letièmbre

et al. 2013

JAD

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In Alzheimer's disease (AD), fatal neuronal cell loss occurs long before relevant evidence can lead to a reliable diagnosis. If characteristic pathological alterations take place in the enteric nervous system (ENS), it could be one of the most promising targets for an early diagnosis, using submucosal biopsies from the gut. We therefore investigated time- and spatial-dependent changes in an amyloid-β protein precursor (AβPP) overexpressing transgenic mouse model to examine early changes within the ENS. Wholemount preparations and paraffin sections were analyzed for the expression of neuronal, glial, and innate immunity markers. Isolated myenteric networks were screened for differences in overall protein expression, and a motility analysis delivered functional data. The level of AβPP in the gut was significantly higher in the AD mouse model than in wild-type mice and also higher in the gut than in the brain at all ages investigated. The transcriptional level of Nestin, GFAP, and TLR4 increased with age with a peak at 3 months. At the protein level, human amyloid-β was located in myenteric neurons. Myenteric networks showed a reduction of the neuronal density in AβPP compared to wild-type mice, which was functionally relevant as revealed by motility analysis. The ENS undergoes significant changes during the early onset of AβPP expression in AD mouse models that appear before those seen in the brain as demonstrated in this study. Thus, there is a chance of determining similar alterations in the human gut of AD patients, which could be used to develop early diagnostic approaches.

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Immunoreactivity for β/A4 protein, but not for its precursor, in human chromaffin cells

Cited by 3 publications

References 30 publications

Neurotrophins and neurotrophin receptors in some neural crest‐derived tumours (ganglioneuroma, phaeochromocytoma and paraganglioma)

Neurotrophins and neurotrophin receptors in some neural crest‐derived tumours (ganglioneuroma, phaeochromocytoma and paraganglioma)

S‐100 proteins in the human peripheral nervous system

Changes of the Enteric Nervous System in Amyloid-β Protein Precursor Transgenic Mice Correlate with Disease Progression

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