Immunoregulatory abnormalities in patients with pigeon breeder’s disease

Hypersensitivity Pneumonitis: Clinical Manifestations, Pathogenesis, Diagnosis, and Therapeutic Strategies

“…However, in a subgroup of asymptomatic pigeon breeders, we have demonstrated a low concanavalin A-induced suppression similar to that found in patients manifesting PBD. 26 In another subgroup of asymptomatic pigeon breeders, concanavalin A did not induce supression similar to that of normal individuals. 26 The percentage of BAL macrophages in HP is very low.…”

“…26 In another subgroup of asymptomatic pigeon breeders, concanavalin A did not induce supression similar to that of normal individuals. 26 The percentage of BAL macrophages in HP is very low. However, because of the severalfold increase of the total cells recovered in BAL, the absolute number of macrophages is compared to those in controls.…”

Pigeon breeder's lung in childhood: Varied clinical picture at presentation

“…A decrease in T-cell-induced suppression in affected individuals, when compared with asymptomatic breeders and normal subjects, may partially explain patients' cellular and humoral hyperreactivity. 7 In these individuals, Tcells also recognize a wide range of bird proteins, which induce a marked T-cell proliferation. 8 Furthermore, mucociliary clearance is impaired with reduced clearance of antigen.…”