Immunoregulatory functions of PD-1/PD-L1 inhibitors and development of resistance to them

Саяпина, М. С.

doi:10.18027/2224-5057-2017-2-94-99

Cited by 7 publications

(1 citation statement)

References 53 publications

(57 reference statements)

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“…PD-L1 экспрессируется на макрофагах, поверхности Т-и В-лимфоцитов, дендритных клеток, эндотелиальных клеток сердца, гемопоэтических, эпителиальных, глиальных клеток, клеток плаценты, паренхиматозных клеток (β-клеток поджелудочной железы, эндотелиально-сосудистых клеток) [6]. PD-L1 препятствует развитию аутоиммунных реакций, содействует диф-ференцировке наивных клеток CD4+ в индуцируемые CD4+FOXP3+Treg [7,8]. PD-L1 является продуктом гена CD274, который располагается на 9-й хромосоме.…”

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Expression of Programmed Cell Death Protein 1 (Pd-1) and Its Ligand Pd-L1 in High-Grade Serous Ovarian Cancer

Zhurman,

Plekhova

2023

Ulyanovsk Medico-biological Journal

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Recently, the immunotherapeutic treatment of ovarian cancer is of much concern. This is due to the discovery of the signaling pathway of the PD-1/PD-L1 immune checkpoints, which are capable of controlling autoimmune response severity and duration. The aim of the study is to determine the dependence of PD-1/PD-L1 expression on the proliferative activity of high-grade serous ovarian cancer cells. Materials and Methods. The study was performed at Central Research Laboratory, Pacific State Medical University, Ministry of Health of the Russian Federation. The material was collected at Primorsky Regional Oncological Dispensary, 2016–2021. The pathological and anatomical samples were analyzed by immunohistochemistry using p53, Ki-67, PD-L1, and Anti-Hu CD279 (PD-1). The main group included 74 patients with high-grade serous ovarian cancer, the comparative group consisted of 26 patients with benign ovarian tumors. Results. PD-1/PD-L1 expression was observed in tumor tissues in ovarian cancer. There was also an increase in the positive reaction to Ki-67 and p53 according to grading and staging of cancer. Conclusion. Despite the claimed immunomodulatory function, high PD-1/PD-L1 levels are favorable prognostic indicators in ovarian cancer. The obtained data show that PD-1/PD-L1 molecules are biologically significant regulators of the immune response in high-grade serous ovarian cancer, which is an argument in favor of immune checkpoint inhibitors. Thus, PD-L1 in the immune cells infiltrating the tumor is a favorable prognostic factor. A statistically significant direct correlation between Ki-67 and PD-L1 proves a direct dependence of PD-L1 expression on proliferative activity of the ovarian tumor. A statistically significant inverse correlation between p53 and PD-1 shows the dependence of PD-1 expression on apoptotic changes in the ovarian tumor.

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Expression of Programmed Cell Death Protein 1 (Pd-1) and Its Ligand Pd-L1 in High-Grade Serous Ovarian Cancer

Zhurman,

Plekhova

2023

Ulyanovsk Medico-biological Journal

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Activity of Negative Regulation of the PD-1/PD-L1/PD-L2 T-Cell Response System in Patients with Pneumonia and Inﬂuenza A (H1N1)

Малярчиков

Шаповалов

Лукьянов

et al. 2021

Obŝaâ reanimatologiâ

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Systemic inﬂammation is an integral pathophysiological component of many critical illnesses. The systemic inﬂammatory response is based on a cascade of interactions leading to hypercytokinemia and, as a consequence, multiple organ failure, which is one of the main causes of mortality in intensive care units.Aim of the study. To evaluate the activity of the negative regulation system of T-cell response by determining the plasma levels of PD-1, PD-L1 and PD-L2 molecules in pneumonia patients with inﬂuenza A (H1N1).Materials and methods. 85 patients with pneumonia and underlying inﬂuenza A (H1N1) were examined. Among them there were 30 patients with severe pneumonia, and 55 patients with non-severe pneumonia. Plasma levels of PD-1, PD-L1, PD-L2 molecules was determined by ﬂow cytoﬂuorometry method.Results. In patients with severe pneumonia and underlying inﬂuenza A (H1N1), the plasma level of PD-1 receptor increased 4.6-fold, while the concentration of its ligands PD-L1 and PD-L2 increased 10.6 and 2.2-fold, respectively.Conclusion. Signiﬁcant increase in levels of PD-1 and its ligands PD-L1 and PD-L2 in patients with pneumonia and underlying inﬂuenza A (H1N1) indicates the involvement of negative regulation system of T-cell response in the cascade of immunological reactions and is associated with the severe disease. Possible correction of immune reactions realized through PD-1/PD-L1/PD-L2 complex in critically ill patients is a promising research avenue.

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Study of association between molecular marker expression on tumor and immunocompetent cells and sensitivity to adjuvant and neoadjuvant therapy of bladder cancer

et al. 2019

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Use of immunotherapy in treatment of muscle-invasive bladder cancer remains the most promising method in case of impossibility of chemotherapy with cisplatin or progression during cisplatin treatment. This approach is the method of choice and can prolong patient’s life. In particular, use of checkpoint inhibitors allows to obtain effective treatment of bladder cancer. However, to prescribe immunotherapeutic medication, patient must have point of application for these drugs. Individualized approach will allow to increase treatment effectiveness and disease prognosis while maximally improving the quality of life.

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Immunoregulatory functions of PD-1/PD-L1 inhibitors and development of resistance to them

Cited by 7 publications

References 53 publications

Expression of Programmed Cell Death Protein 1 (Pd-1) and Its Ligand Pd-L1 in High-Grade Serous Ovarian Cancer

Expression of Programmed Cell Death Protein 1 (Pd-1) and Its Ligand Pd-L1 in High-Grade Serous Ovarian Cancer

Activity of Negative Regulation of the PD-1/PD-L1/PD-L2 T-Cell Response System in Patients with Pneumonia and Inﬂuenza A (H1N1)

Study of association between molecular marker expression on tumor and immunocompetent cells and sensitivity to adjuvant and neoadjuvant therapy of bladder cancer

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