Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

Santoro, Aurelia; Bientinesi, Elisa; Monti, Daniela

doi:10.1016/j.arr.2021.101422

Cited by 299 publications

(228 citation statements)

References 255 publications

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“…Aging causes increased proinflammatory memory T cells and decreases the number of naïve T cells. This whole process is likely linked to the chronic inflammation seen in aging, or “inflammaging” [ 103 ]. In breast cancer, several studies have correlated “inflammaging” with changes in micro-RNA and chronic inflammation.…”

Section: Breast Cancer and Radiation Response In Aged Populationmentioning

confidence: 99%

Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer

Shastri

Lombardo

Okere

et al. 2021

IJMS

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Understanding metabolic and immune regulation inherent to patient populations is key to improving the radiation response for our patients. To date, radiation therapy regimens are prescribed based on tumor type and stage. Patient populations who are noted to have a poor response to radiation such as those of African American descent, those who have obesity or metabolic syndrome, or senior adult oncology patients, should be considered for concurrent therapies with radiation that will improve response. Here, we explore these populations of breast cancer patients, who frequently display radiation resistance and increased mortality rates, and identify the molecular underpinnings that are, in part, responsible for the radiation response and that result in an immune-suppressive tumor microenvironment. The resulting immune phenotype is discussed to understand how antitumor immunity could be improved. Correcting nutrient deficiencies observed in these populations should be considered as a means to improve the therapeutic index of radiation therapy.

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Section: Breast Cancer and Radiation Response In Aged Populationmentioning

confidence: 99%

Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer

Shastri

Lombardo

Okere

et al. 2021

IJMS

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“…The term "Inflamm-aging" was first conceived by Franceschi and his group, who suggested that up-regulation of the inflammatory response at an older age results from a lowgrade, chronic, systemic pro-inflammatory state, and that this state contributes to age-associated diseases [8]. Aging is a process involving both the innate and the adaptive immune system [9]. Senescence of the adaptive immune system is characterized by the loss of naive T cells; as the memory T cell pool increases, it results in a limited T-cell receptor (TCR) repertoire [10].…”

Section: Introductionmentioning

confidence: 99%

“…Senescence of the adaptive immune system is characterized by the loss of naive T cells; as the memory T cell pool increases, it results in a limited T-cell receptor (TCR) repertoire [10]. The innate immune system also contributes to aging [9]. Native immune cells are the first line of host defense, constantly challenged by exogenous and endogenous stimuli.…”

Section: Introductionmentioning

confidence: 99%

The innate immune system in human kidney inflammaging

et al. 2021

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Elderly individuals with chronic disorders tend to develop inflammaging, a condition associated with elevated levels of blood inflammatory markers, and increased susceptibility to chronic disease progression. Native and adaptive immunity are both involved in immune system senescence, kidney fibrosis and aging. The innate immune system is characterized by a limited number of receptors, constantly challenged by self and non-self stimuli. Circulating and kidney resident myeloid and lymphoid cells are all equipped with pattern recognition receptors (PRRs). Recent reports on PRRs show kidney overexpression of toll-like receptors (TLRs) in inflammaging autoimmune renal diseases, vasculitis, acute kidney injury and kidney transplant rejection. TLR upregulation leads to proinflammatory cytokine induction, fibrosis, and chronic kidney disease progression. TLR2 blockade in a murine model of renal ischemia reperfusion injury prevented the escape of natural killer cells and neutrophils by inflammaging kidney injury. Tumor necrosis factor-α blockade in endothelial cells with senescenceassociated secretory phenotype significantly reduced interleukin-6 release. These findings should encourage experimental and translational clinical trials aimed at modulating renal inflammaging by native immunity blockade. KeywordsAcute kidney injury • Aging • COVID-19 • Hemodialysis • Inflammaging • Innate immune system Abbreviations ACE2 Angiotensin-converting enzyme 2 aHUS Atypical hemolytic uremic syndrome (thrombotic microangiopathy) ANCA Anti-neutrophil cytoplasmic antibody AP Complement alternative pathway ASC Or PYCARD is an apoptosis-associated speck-like protein containing a CARD ATN Acute tubular necrosis AKI Acute kidney injury CARD Caspase recruitment domain CD Cluster of differentiation CKD Chronic kidney disease CMV Cytomegalovirus COVID-19 Corona virus disease-2019 novel coronavirus CXCL16 Chemokine (C-X-C motif) ligand 16 CTLRs C-type lectin receptors CP Complement classical pathway CRP C-reactive protein CXCR6 C-X-C motif chemokine receptor 6 DCs Dendritic cells DAMPs Dander-associated molecular patterns or alarmins DGF Delayed graft function DKD Diabetic kidney disease or diabetic nephropathy ds Double-stranded ECM Extracellular matrix eNOS Endothelial nitric oxide synthase ESRD End-stage renal disease FGF-2 Fibroblast growth factor 2 * Vincenzo Sepe

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“…Age-related changes in the gut microbiota may be associated with immunosenescence, or age-related dysfunction of the immune system, in humans [3]. Immunosenescence may lead to "inflammaging," low-grade chronic inflammation that contributes to age-related diseases [10]. Indeed, detrimental effects of aging in cats include an increased risk of a variety of conditions associated with inflammation such as chronic kidney disease (CKD), diabetes, gastrointestinal disease, cancer, and cognitive decline [11,12].…”

Section: Introductionmentioning

confidence: 99%

Effect of Nutrition on Age-Related Metabolic Markers and the Gut Microbiota in Cats

Ephraim¹,

Jewell

2021

Microorganisms

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Age-related changes in the gut microbiota and metabolites are associated with the increased risk of detrimental conditions also seen with age. This study evaluated whether a test food with potential anti-aging benefits results in favorable changes in plasma and fecal metabolites and the fecal microbiota in senior cats. Forty healthy domestic cats aged 8.3–13.5 years were fed a washout food for 30 days, then control or test food for 30 days. After another 30-day washout, cats were switched to the other study food for 30 days. Assessment of plasma and fecal metabolites showed lower levels of metabolites associated with detrimental processes (e.g., uremic toxins) and higher levels of metabolites associated with beneficial processes (e.g., tocopherols) after cats consumed the test food compared with the control food. A shift toward proteolysis with the control food is supported by higher levels of amino acid metabolites and lower levels of carbohydrate metabolites. Operational taxonomic units of greater abundance with the test food positively correlated with carbohydrate and nicotinic acid metabolites, and negatively correlated with uremic toxins, amino acid metabolism, secondary bile salts, and branched-chain fatty acids. Taken together, the test food appears to result in greater levels of metabolites and microbiota associated with a healthier state.

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Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

Cited by 299 publications

References 255 publications

Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer

Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer

The innate immune system in human kidney inflammaging

Effect of Nutrition on Age-Related Metabolic Markers and the Gut Microbiota in Cats

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