Immunosuppression in broilers under experimental aflatoxicosis

Ghosh, R. C.; Chauhan, Himanshu

doi:10.1016/0007-1935(90)90035-2

Cited by 34 publications

(17 citation statements)

References 19 publications

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“…In contrast to our study dietary AF has been reported to cause vaccine failure as indicated by significantly reduced (P<0.05) antibody titres against Newcastle disease vaccine when birds were fed diets containing 2000 to 3000 ppb AF (Rathore et al, 1987;Mangat et al, 1988;Viridi et al, 1989;Ghosh et al, 1990;Bakshi, 1991;Mohiuddin and Reddy, 1993;Sharma, 1993;Mohiudin, 1993). Similarly, Azzam and Gabal (1998) reported that even low levels of dietary AF (200 ppb) can cause reduction in antibody titers to vaccines for Newcastle disease, infectious bronchitis, and infectious bursal disease in layers, when fed for a longer period (40 weeks).…”

Section: Antibody Titrecontrasting

confidence: 93%

Comparative Evaluation of Different Techniques for Aflatoxin Detoxification in Poultry Feed and Its Effect on Broiler Performance

Mahmood¹,

Pasha²,

Khattak³

2011

Aflatoxins - Detection, Measurement and Control

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Section: Antibody Titrecontrasting

confidence: 93%

Comparative Evaluation of Different Techniques for Aflatoxin Detoxification in Poultry Feed and Its Effect on Broiler Performance

Mahmood¹,

Pasha²,

Khattak³

2011

Aflatoxins - Detection, Measurement and Control

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“…Segundo GHOSH et al (1990), ocorre uma diminuição da síntese protéica pelo fígado e uma redução dos níveis séricos de albumina e globulinas nos frangos de corte quando alimentados com dietas contendo 30ppb de aflatoxinas. Uma das vantagens da utilização de quirera de arroz na dieta dos animais é a ausência ou o nível muito reduzido de micotoxinas devido à forma de colheita e processamento do arroz (BUTOLO, 2002).…”

Section: Introductionunclassified

Dietas para frangos de corte contendo quirera de arroz

et al. 2007

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RESUMO O experimento foi realizado para avaliar o uso da quirera de arroz na dieta de frangos de corte. Foram utilizados INTRODUÇÃOO avanço da nutrição exige cada vez mais dos nutricionistas a busca por alimentos com alta digestibilidade que sejam economicamente viáveis. A avaliação de alimentos alternativos e o uso destes na alimentação animal possibilitam a redução dos custos de produção, com reflexos diretos sobre a viabilidade do sistema produtivo avícola.O arroz (Oryza sativa L.) é mundialmente produzido para ser consumido por humanos. Entretanto, quando não estiver dentro das especificações para o consumo humano ou quando razões econômicas o permitem, pode ser utilizado na

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“…AFB1 can induce circulating lymphocytopenia [34, 159,166,168] and cause lymphoid depletion in the bursa, spleen and thymus [34,134,139,149,150,159,166]. This likely results from increased apoptosis of splenocytes, thymocytes and bursal B-cells as seen in young chickens during aflatoxicosis [139,149,156,169,170].…”

Section: Immunotoxicitymentioning

confidence: 99%

“…In contrast, the phagocytic activity of thrombocytes was not affected in chickens fed an aflatoxin-contaminated diet [165]. Dietary AFB1 inhibits T lymphocyte activation in both chickens and turkeys as evidenced by delayed hypersensitive skin tests and graft-versus-host response tests [39,84,116,122,159,166,167].…”

Section: Immunotoxicitymentioning

confidence: 99%

Aflatoxicosis: Lessons from Toxicity and Responses to Aflatoxin B1 in Poultry

2015

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This review is a comprehensive introduction to the effects of poultry exposure to the toxic and carcinogenic mycotoxin aflatoxin B1 (AFB1). The relationship between AFB1 sensitivity and metabolism, major direct and indirect effects of AFB1, recent studies of gene expression and transcriptome responses to exposure, and mitigation strategies to reduce toxicity are discussed. Exposure to AFB1 primarily occurs by consumption of contaminated corn, grain or other feed components. Low levels of residual AFB1 in poultry feeds can cause reduction in growth, feed conversion, egg production, and compromised immune functions, resulting in significant economic costs to producers. Thus, AFB1 acts as a "force multiplier" synergizing the adverse effects of microbial pathogens and other agents, and factors detrimental to poultry health. Domestic turkeys (Meleagris gallopavo) are one of the most sensitive animals known to AFB1 due, in large part, to a combination of efficient hepatic bioactivation by cytochromes P450 1A5 and 3A37, and deficient hepatic glutathione-S-transferase (GST)-mediated detoxification. Because of their sensitivity, turkeys are a good model to investigate chemopreventive treatments and feed additives for their ability to reduce AFB1 toxicity. Transcriptome analysis (RNA-seq) of turkey poults (liver and spleen) has identified AFB1-induced gene expression changes in pathways of apoptosis, carcinogenesis, lipid regulation, antimicrobial activity, cytotoxicity and antigen presentation. Current research focuses on further identifying the molecular mechanisms OPEN ACCESSAgriculture 2015, 5 743 underlying AFB1 toxicity with the goal of reducing aflatoxicosis and improving poultry health.

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Immunosuppression in broilers under experimental aflatoxicosis

Cited by 34 publications

References 19 publications

Comparative Evaluation of Different Techniques for Aflatoxin Detoxification in Poultry Feed and Its Effect on Broiler Performance

Comparative Evaluation of Different Techniques for Aflatoxin Detoxification in Poultry Feed and Its Effect on Broiler Performance

Dietas para frangos de corte contendo quirera de arroz

Aflatoxicosis: Lessons from Toxicity and Responses to Aflatoxin B1 in Poultry

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