Immunosuppressive effects of Echinodorus macrophyllus aqueous extract

Oxidative stress has been considered as one of the factors responsible for hepatic diseases, which sometimes require new ways of treatment. The present study aimed to evaluate the in vitro antioxidant capacity of the tea of Echinodorus grandiforus ("leather hat" plant) in rat liver. Different preparations of tea were evaluated for phenolic composition, antioxidant activity by DPPH assay and ability to inhibit lipid peroxidation induced by copper sulfate. The antioxidant activity was assessed in liver tissue treated with sodium azide in the presence or absence of tea by assays for lipid peroxidation (TBARS), protein oxidation (carbonyl) and the antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD). The results show that different preparations of tea are important sources of polyphenols and contain theobromine, catechin and vitexin. Furthermore, the results indicate that this tea exhibits an antioxidant activity by its ability to scavenge DPPH radical. Different preparations of tea prevented damage to lipids and proteins induced by sodium azide, as well as assisting in restoring CAT and SOD activities. Thus, it can be seen that E. grandiforus tea had antioxidant activity in serum and liver being able to prevent oxidative damages generated by sodium azide.

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“…First, four concentrations of tea were prepared (5, 10, 15, and 20 g/100 mL), based on previous studies (Pinto et al 2007, Garcia et al 2010.…”

Section: Chemicalsmentioning

confidence: 99%

In vitro antioxidant capacity of tea of Echinodorus grandiforus, “leather hat,” in Wistar rat liver

Lunardi¹,

Wohlenberg²,

Medeiros³

et al. 2014

An. Acad. Bras. Ciênc.

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“…100 and 300 mg/kg (Mukherjee et al, 1995a;Rai et al, 2006), DMS (2 mg/kg) (Pinto et al, 2007). Aqueous suspension of the extracts and standard drugs were prepared using distilled water.…”

Section: Selection Of Dosementioning

confidence: 99%

Immunomodulatory potential of rhizome and seed extracts of Nelumbo nucifera Gaertn.

Mukherjee¹,

Khatua²,

Venkatesh³

et al. 2010

Journal of Ethnopharmacology

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“…Pinto et al 7 reported that the immunosuppressive effect supports a potential therapeutic use of aerial parts of the E. macrophyllus plant to control exacerbated humoral and= or cellular immune responses, as in autoimmune rheumatic diseases.…”

Section: Introductionmentioning

confidence: 97%

Topical and Systemic Anti-Inflammatory Effects of Echinodorus macrophyllus (Kunth) Micheli (Alismataceae)

Tanus-Rangel

Santos

Lima

et al. 2010

Journal of Medicinal Food

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Echinodorus macrophyllus leaf has been used in Brazilian folk medicine to treat inflammatory conditions and kidney dysfunctions. The present study evaluated the effects of leaf ethanolic extract from E. macrophyllus (EEEm) in acute and subchronic models of inflammation. The EEEm was found to cause significant and potent inhibition of carrageenan- and dextran-induced paw edema in rats and marked decreases in the exudate volume and leukocyte migration in rats with carrageenan-induced pleurisy, the vascular permeability increase induced by intraperitoneal acetic acid, and the croton oil-induced topical ear edema in mice. On the other hand, the EEEm was not active in the test model of cotton pellet-induced granuloma in rats. Phytochemical analysis with E. macrophyllus leaves revealed the presence of triterpenoids, steroids, flavones, flavonols, and xanthones. Two flavonoids were isolated from the ethyl acetate fraction and identified as isovitexin and vitexin. Our results support the traditional use of E. macrophyllus leaves in the treatment of acute inflammatory conditions.

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Immunosuppressive effects of Echinodorus macrophyllus aqueous extract

Cited by 27 publications

References 22 publications

In vitro antioxidant capacity of tea of Echinodorus grandiforus, “leather hat,” in Wistar rat liver

In vitro antioxidant capacity of tea of Echinodorus grandiforus, “leather hat,” in Wistar rat liver

Immunomodulatory potential of rhizome and seed extracts of Nelumbo nucifera Gaertn.

Topical and Systemic Anti-Inflammatory Effects of Echinodorus macrophyllus (Kunth) Micheli (Alismataceae)

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