Immunosuppressive pregnane glycosides from Periploca sepium and Periploca forrestii

Feng, Jia‐Quan; Zhang, Rujun; Zhou, Yu; Chen, Zhenhua; Tang, Wei; Liu, Qunfang; Zuo, Jian‐Ping; Zhao, Weimin

doi:10.1016/j.phytochem.2008.08.015

Cited by 58 publications

(49 citation statements)

References 23 publications

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“…The compound showed dosedependent relaxation on aortic rings with endothelium contracted by phenylepherine or KCI. 396 The structures of a series of peroxy function containing pregnane glycosides including periperoxides A-E 635-639 397 and previously reported periplocosides A-K 398,399 have been revised to be orthoester group bearing ones using 2D NMR techniques as well as chemical transformations and X-ray crystallographic diffraction analysis. …”

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confidence: 99%

Peroxy natural products

Liu

2013

Nat. Prod. Bioprospect.

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confidence: 99%

Peroxy natural products

Liu

2013

Nat. Prod. Bioprospect.

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“…Periploca is one of the genus in Asclepiadaceae family and is widely distributed in the north and tropical Africa, and East Asia [1]. Cortex Periplocae has a special feature and shape.…”

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confidence: 99%

“…Traditionally, Cortex Periplocae has been used to treat rheumatism and strengthen bones and tendons, and it is regarded as an effective tonic medicine [3]. Currently, more than 100 compounds have been identified from Cortex Periplocae, some C 21 -steroidal glycosides and terpenoids have demonstrated special immunosuppressive activity [1,4]. Besides its characteristic antirheumatic effect, it was shown to specifically treat heart failure.…”

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confidence: 99%

A Review on Phytochemistry and Pharmacology of Cortex Periplocae

Yang

Zhou

et al. 2016

Molecules

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Cortex Periplocae, as a traditional Chinese herbal medicine, has been widely used for autoimmune diseases, especially rheumatoid arthritis. Due to its potential pharmaceutical values, more studies about the biological activities of Cortex Periplocae have been conducted recently. Meanwhile, the adverse reaction of Cortex Periplocae is not a negligible problem in clinic. In this article, we reviewed a series of articles and summarized the recent studies of Cortex Periplocae in the areas of phytochemistry and pharmacology. More than 100 constituents have been isolated and identified from Cortex Periplocae, including steroids, cardiac glycosides, terpenoids, and fatty acid compounds. The crude extracts of Cortex Periplocae and its active compounds exhibit various biological activities, such as cardiotonic effect, anticancer action, and anti-inflammatory effect. This paper aims to provide an overall review on the bioactive ingredients, pharmacological effect, and toxicity of this plant. Furthermore, this review suggests investigating and developing new clinical usages according to the above pharmacological effects.

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“…Periploca is one of the genus in Asclepiadaceae family and is widely distributed in the north and tropical Africa, Orient, and East Asia [1]. Cortex Periplocae has a special feature and shape.…”

Section: Introductionmentioning

confidence: 99%

A Review on Phytochemistry and Pharmacology of <em>Cortex Periplocae</em>

Zhou

et al. 2016

Preprint

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Abstract:Cortex Periplocae, as a traditional Chinese herbal medicine, has been widely used for autoimmune diseases, especially rheumatoid arthritis. Due to its potential pharmaceutical values, more studies about the biological activities of Cortex Periplocae have been conducted recently. Meanwhile, the adverse reaction of Cortex Periplocae is not a negligible problem in clinic. In this article, we reviewed a series of articles and summarized the recent studies of Cortex Periplocae in the areas of phytochemistry and pharmacology. More than 100 constituents have been isolated and identified from Cortex Periplocae, including steroids, cardiac glycosides, terpenoids, and fatty acid compounds. The crude extracts of Cortex Periplocae and its active compounds exhibit various biological activities, such as cardiotonic effect, anticancer action, and anti-inflammatory effect. This paper aims to provide an overall review on the bioactive ingredients, pharmacological effect, and toxicity of this plant. Furthermore, this review suggests investigating and developing new clinical usages according to the above pharmacological effects.

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Immunosuppressive pregnane glycosides from Periploca sepium and Periploca forrestii

Cited by 58 publications

References 23 publications

Peroxy natural products

Peroxy natural products

A Review on Phytochemistry and Pharmacology of Cortex Periplocae

A Review on Phytochemistry and Pharmacology of <em>Cortex Periplocae</em>

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