Immunotherapy for childhood asthma: Is there a rationale for its use?

Sigman, Karen; Mazer, Bruce

doi:10.1016/s1081-1206(10)60029-4

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…Allergen immunotherapy is defined by the World Health Organization as therapeutic vaccination for allergic diseases [79]. Although debate about the value of immunotherapy continues, meta-analysis and review of immunotherapy support its potential value in childhood [80]. Early immunotherapy may prevent the development of asthma in children sensitized to house dust mites [81].…”

Section: Immunotherapymentioning

confidence: 99%

2003 Canadian Asthma Consensus Guidelines Executive Summary

Becker

Lemière

Bérubé

et al. 2006

All Asth Clin Immun

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BackgroundGuidelines for the diagnosis and management of asthma have been published over the last 15 years; however, there has been little focus on issues relating to asthma in childhood. Since the last revision of the 1999 Canadian Asthma Consensus Report, important new studies, particularly in children, have highlighted the need to incorporate new information into the asthma guidelines. The objectives of this article are to review the literature on asthma published between January 2000 and June 2003 and to evaluate the influence of new evidence on the recommendations made in the 1999 Canadian Asthma Consensus Report and its 2001 update, with a major focus on pediatric issues.MethodsThe diagnosis of asthma in young children and prevention strategies, pharmacotherapy, inhalation devices, immunotherapy, and asthma education were selected for review by small expert resource groups. The reviews were discussed in June 2003 at a meeting under the auspices of the Canadian Network For Asthma Care and the Canadian Thoracic Society. Data published through December 2004 were subsequently reviewed by the individual expert resource groups.ResultsThis report evaluates early-life prevention strategies and focuses on treatment of asthma in children, emphasizing the importance of early diagnosis and preventive therapy, the benefits of additional therapy, and the essential role of asthma education.ConclusionWe generally support previous recommendations and focus on new issues, particularly those relevant to children and their families. This document is a guide for asthma management based on the best available published data and the opinion of health care professionals, including asthma experts and educators.

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Section: Immunotherapymentioning

confidence: 99%

2003 Canadian Asthma Consensus Guidelines Executive Summary

Becker

Lemière

Bérubé

et al. 2006

All Asth Clin Immun

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“…Allergy can be an important trigger. It has been shown that allergen exposure can induce the expression of Intercellular Adhesion-molecule-l (ICAM-l): this molecule acting as a receptor for 90% ofhuman rhinovirus, the expression ofICAM-1can raise the susceptibility of a patient to rhinovirus infections (7).…”

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confidence: 99%

Sublingual Allergen-Specific Immunotherapy in Allergic Rhinitis and Related Pathologies: Efficacy in a Paediatric Population

Volpe

D’Agostino

Varricchio

et al. 2002

Int J Immunopathol Pharmacol

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The aim of this study was to demonstrate the efficacy and safety of the sublingual-swallow allergen-specific immunotherapy (SLIT) in a paediatric population suffering from allergic rhinitis and related pathologies. From March 1994 through March 2000, at our ENT Department 4000 children (1800 male and 2200 female), aged 3 to14 years, were examined for recurrent nasal obstruction and nasal polyps. 2400 (60%) of them were allergic and underwent the following investigations: Impedance test, Pure tone audiometry, rhinomanometry, Prick test, RAST, nasal provocation test and paranasal sinus TC without contrast media. Of the allergic group we admitted 288 patients(12%) to a 3 yr SLIT, meeting the following criteria: children aged 5 years or more, mono-sensitised to one allergen and with family cooperation support. After three years of SLIT, we observed complete symptom remission and a marked improvement in instrumental examinations in 80% of these children. The improvement was poor in 8% of patients, while in 12% of the subjects no changes in symptoms and instrumental results were detected. These results are in agreement with previously published studies and confirm that SLIT can be a valid tool for treating allergic upper respiratory tract diseases in children.

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Immunotherapy for Asthma

Cantani

Rienzo

et al. 1998

Annals of Allergy, Asthma & Immunology

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Immunotherapy for childhood asthma: Is there a rationale for its use?

Cited by 5 publications

References 31 publications

2003 Canadian Asthma Consensus Guidelines Executive Summary

2003 Canadian Asthma Consensus Guidelines Executive Summary

Sublingual Allergen-Specific Immunotherapy in Allergic Rhinitis and Related Pathologies: Efficacy in a Paediatric Population

Immunotherapy for Asthma

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