Immunotherapy of bovine ocular squamous cell carcinoma by repeated intralesional injections of live bacillus Calmette-Guérin (BCG) or BCG cell walls

Rutten, Victor P.M.G.; Klein, W. R.; Jong, W. A. C. De; Steerenberg, P. A.; Jong, Wim H. de; Otter, W. Den; Ruitenberg, E. J.

doi:10.1007/bf01742311

Cited by 12 publications

(7 citation statements)

References 28 publications

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“…In the present study, animals with small localized eye tumors where vision was not affected were treated with intralesional injection of BCG vaccine at 0, 14, 35, 56 days intervals (Rutten et al, 1991). A decrease in size, drying, shrinkage of eye tumors was observed in all the animals after 4 th injection.…”

Section: Resultsmentioning

confidence: 59%

“…The incidence of eye cancer in cattle was found to be high in age group of above 5 years followed by 2-5 years (Rutten et al 1991). This could be due to the allowing of adult animals to outside leading to exposure to radiation.…”

Section: Resultsmentioning

confidence: 98%

“…A decrease in size, drying, shrinkage of eye tumors was observed in all the animals after 4 th injection. There was no recurrence after repeated treatments for a period of 6 months (Rutten et al, 1991 andRadhakrishnan et al, 1999). BCG is a potent stimulator of B and T cells especially the enrichment of natural killer cell activity.…”

Section: Resultsmentioning

confidence: 99%

“…In group II, animals were subjected to intralesional injection of BCG vaccine (Tubervac, Dheer Healthcare Private Limited, Mumbai) at 0, 14, 35 and 56 days interval. Depending on the size of the tumor 2-4 ml vaccine was injected (Rutten et al, 1991) to saturate the whole tumour.…”

Section: Methodsmentioning

confidence: 99%

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Efficacy of Different Treatment Modalities for Eye Cancer in Bovines

Lakshmi¹,

Veena²,

Kumar³

et al. 2021

IJAR

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Background: Bovine ocular squamous cell carcinoma also called cancer eye, represents the most economically important neoplasm in large animals. Hereditary factors, environmental factors (e.g: latitude, altitude, exposure to sunlight), lack of eyelid pigmentation, age and dietary habits have all been reported to play a role in the etiopathogenesis of bovine ocular squamous cell carcinoma. In addition, in cattle the etiology has been linked to a number of viral agents, especially bovine papilloma virus and bovine herpes virus type 1 and 5. Nevertheless, ultraviolet light, viruses and circumocular pigmentation are the major epidemiologic risk factors for the development of the tumor. The efficacy of different treatment modalities for eye cancer in bovines was studied.Methods: All the animals were divided in to four groups of six animals each. Surgical excision, intra lesion BCG vaccine, surgery with auto vaccine and surgery with mitomycin was the treatment protocols followed. Immunohistochemical studies were conducted to know the rate of proliferation of bovine ye cancer. Immunopositive reaction was observed against Vascular Endothelial Growth Factor and Epidermal Growth Factor Receptor in all the cases.Result: The benefits of different treatment modalities depended on nature, type, location and extensiveness of tumor. Early detection and aggressive treatment were essential in the successful management of these tumors. A multimodal treatment approach was recommended with surgery, immunotherapy and chemotherapy in providing 100% disease free interval.

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Section: Resultsmentioning

confidence: 59%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of Different Treatment Modalities for Eye Cancer in Bovines

Lakshmi¹,

Veena²,

Kumar³

et al. 2021

IJAR

View full text Add to dashboard Cite

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“…Local vaccination with bacillus Calmette-Guérin (BCG) has long been used as a therapeutic treatment for superficial cancer of the urinary tract in humans and has been shown to be effective in the treatment of equine sarcoids and, to a lesser extent, bovine ocular squamous cell carcinoma (105,153). The mode of action of this vaccination regimen is unknown but may involve the upregulation of tumor-specific antigens through local inflammation and activation of the innate immune system (162).…”

Section: Cancer Vaccinesmentioning

confidence: 99%

Current Status of Veterinary Vaccines

et al. 2007

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SUMMARY The major goals of veterinary vaccines are to improve the health and welfare of companion animals, increase production of livestock in a cost-effective manner, and prevent animal-to-human transmission from both domestic animals and wildlife. These diverse aims have led to different approaches to the development of veterinary vaccines from crude but effective whole-pathogen preparations to molecularly defined subunit vaccines, genetically engineered organisms or chimeras, vectored antigen formulations, and naked DNA injections. The final successful outcome of vaccine research and development is the generation of a product that will be available in the marketplace or that will be used in the field to achieve desired outcomes. As detailed in this review, successful veterinary vaccines have been produced against viral, bacterial, protozoal, and multicellular pathogens, which in many ways have led the field in the application and adaptation of novel technologies. These veterinary vaccines have had, and continue to have, a major impact not only on animal health and production but also on human health through increasing safe food supplies and preventing animal-to-human transmission of infectious diseases. The continued interaction between animals and human researchers and health professionals will be of major importance for adapting new technologies, providing animal models of disease, and confronting new and emerging infectious diseases.

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