Immunotoxicity and neurotoxicity of bisphenol A and microplastics alone or in combination to a bivalve species, Tegillarca granosa

Tang, Yu; Zhou, Weicheng; Sun, Suwan; Du, Xueying; Han, Yu; Shi, Wei; Liu, Guangxu

doi:10.1016/j.envpol.2020.115115

Cited by 135 publications

(29 citation statements)

References 91 publications

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“…In addition, oxidative stress caused by the overproduction of reactive oxygen species (ROS) is one of the most commonly measured biomarkers for environmental contaminant exposure, including MP exposure [ 39 , 40 , 41 ], consistent with our results. In our study, the relative content of oxidized glutathione (GSSG) was increased.…”

Section: Discussionsupporting

confidence: 90%

Microplastics (Polystyrene) Exposure Induces Metabolic Changes in the Liver of Rare Minnow (Gobiocypris rarus)

et al. 2022

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Microplastics are environmental contaminants and an emergent concern. Microplastics are abundant in freshwater and can cause biochemical stress in freshwater organisms. In the current study, rare minnows (Gobiocypris rarus) were exposed to 1μm polystyrene microplastics at 200 μg/L concentration. We observed various sublethal effects after four weeks of exposure but no mortality. Numerous cellular and tissue alterations were observed in the liver. Differential metabolites and differentially expressed genes between control and exposure groups were identified and mapped to pathways in the Kyoto Encyclopedia of Genes and Genomes. The combination of transcriptomic and metabolomic analyses revealed significantly varied metabolic pathways between the two groups. These pathways were involved in glucolipid, amino acid, and nucleotide metabolism. Results demonstrated that MP exposure induced immune reaction, oxidative stress, and disturbed glycolipid and energy metabolism. The current study provided novel insights into the molecular and metabolic mechanisms of microplastic ecotoxicology in rare minnow.

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Section: Discussionsupporting

confidence: 90%

Microplastics (Polystyrene) Exposure Induces Metabolic Changes in the Liver of Rare Minnow (Gobiocypris rarus)

et al. 2022

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“…Secondly, the presence of additives and contaminants in or on microplastics raises concerns about the possible accentuation of the pollutants' toxicity. Indeed, microplastics aggravated the immunotoxicity of bisphenol A and petroleum hydrocarbons in blood clams [125,126], and the immunotoxicity of cadmium in fish [113]. Polyethylene microplastics increased the toxicity of the pesticide chlorpyrifos in the marine copepod Acartia tonsa [127].…”

Section: Microplastics As Carriers Of Intestinal Toxics and Pathogensmentioning

confidence: 99%

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

2020

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Background Together with poor biodegradability and insufficient recycling, the massive production and use of plastics have led to widespread environmental contamination by nano- and microplastics. These particles accumulate across ecosystems - even in the most remote habitats - and are transferred through food chains, leading to inevitable human ingestion, that adds to the highest one due to food processes and packaging. Objective The present review aimed at providing a comprehensive overview of current knowledge regarding the effects of nano- and microplastics on intestinal homeostasis. Methods We conducted a literature search focused on the in vivo effects of nano- and microplastics on gut epithelium and microbiota, as well as on immune response. Results Numerous animal studies have shown that exposure to nano- and microplastics leads to impairments in oxidative and inflammatory intestinal balance, and disruption of the gut’s epithelial permeability. Other notable effects of nano- and microplastic exposure include dysbiosis (changes in the gut microbiota) and immune cell toxicity. Moreover, microplastics contain additives, adsorb contaminants, and may promote the growth of bacterial pathogens on their surfaces: they are potential carriers of intestinal toxicants and pathogens that can potentially lead to further adverse effects. Conclusion Despite the scarcity of reports directly relevant to human, this review brings together a growing body of evidence showing that nano- and microplastic exposure disturbs the gut microbiota and critical intestinal functions. Such effects may promote the development of chronic immune disorders. Further investigation of this threat to human health is warranted.

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“…This is especially important, since the longer the retention time of these particles, the more likely it is that they will be transferred to the next trophic level upon consumption [34], as well as the more time chemicals and other compounds have to potentially desorb from the particles [23,32,35]. A multitude of studies have been conducted on the effects of pristine and contaminated plastic particles on the health of marine mussels [36,37], as well as the thus resulting health effect for humans [38] for different compounds.…”

Section: Introductionmentioning

confidence: 99%

Accumulation, Depuration, and Biological Effects of Polystyrene Microplastic Spheres and Adsorbed Cadmium and Benzo(a)pyrene on the Mussel Mytilus galloprovincialis

Hellfeld

Zarzuelo

Zaldibar

et al. 2022

Toxics

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Filter feeders are target species for microplastic (MP) pollution, as particles can accumulate in the digestive system, disturbing feeding processes and becoming internalized in tissues. MPs may also carry pathogens or pollutants present in the environment. This work assessed the influence of polystyrene (PS) MP size and concentration on accumulation and depuration time and the role of MPs as vectors for metallic (Cd) and organic (benzo(a)pyrene, BaP) pollutants. One-day exposure to pristine MPs induced a concentration-dependent accumulation in the digestive gland (in the stomach and duct lumen), and after 3-day depuration, 45 µm MPs appeared between gill filaments, while 4.5 µm MPs also occurred within gill filaments. After 3-day exposure to contaminated 4.5 µm MPs, mussels showed increased BaP levels whilst Cd accumulation did not occur. Here, PS showed higher affinity to BaP than to Cd. Three-day exposure to pristine or contaminated MPs did not provoke significant alterations in antioxidant and peroxisomal enzyme activities in the gills and digestive gland nor in lysosomal membrane stability. Exposure to dissolved contaminants and to MP-BaP caused histological alterations in the digestive gland. In conclusion, these short-term studies suggest that MPs are ingested and internalized in a size-dependent manner and act as carriers of the persistent organic pollutant BaP.

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Immunotoxicity and neurotoxicity of bisphenol A and microplastics alone or in combination to a bivalve species, Tegillarca granosa

Cited by 135 publications

References 91 publications

Microplastics (Polystyrene) Exposure Induces Metabolic Changes in the Liver of Rare Minnow (Gobiocypris rarus)

Microplastics (Polystyrene) Exposure Induces Metabolic Changes in the Liver of Rare Minnow (Gobiocypris rarus)

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

Accumulation, Depuration, and Biological Effects of Polystyrene Microplastic Spheres and Adsorbed Cadmium and Benzo(a)pyrene on the Mussel Mytilus galloprovincialis

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