Immunotoxicity effect of benzo[α]pyrene on scallop Chlamys farreri

Wang, Qisheng; Pan, Luqing; Liu, Jing

doi:10.1007/s11802-009-0089-6

Cited by 18 publications

(9 citation statements)

References 28 publications

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“…In this study, the pro-PO activity, PO activity, α 2 -M activity, antibacterial activity and bacteriolytic activity of the shrimps were significantly decreased following 6d exposure to high concentrations of BaP and CHR, and presented significant dose response and time response. These results were consistent with the studies of Liu [10] and Zhang [11], and they found that BaP and Aroclor 1254 could inhibit the humoral immune factors of scallop (Chlamys farreri).…”

Section: Effects Of Bap and Chr On Immune Parameterssupporting

confidence: 92%

“…Therefore, the THC in hemolymph was usually used as an important parameter to evaluate the immunotoxicity of pollutions [9]. In this study, the THC in hemolymph of the shrimps decreased significantly under 21d exposures to high concentrations of BaP and CHR, which agrees with the result of Zhang et al [11]. Previous work has indicated the susceptibility of its baseline immune parameters to the PAH phenanthrene, causing alterations in phagocytosis [28].…”

Section: Effects Of Bap and Chr On Immune Parameterssupporting

confidence: 90%

“…Such a decrease in THC has also been reported in crustaceans as a result of the exposures to PAHs [26], PCBs [32] and ammonia-N [18]. The lysosomes play an important role in the immune defense system of crustaceans, which not only take part in phagocytosis, but also can release various hydrolytic enzymes to the haemolymph to participate in the humoral response [11]. Lysosomal damage arising from the accumulation of PAhs and formation of oxyradicals causes an increase in membrane permeability and subsequently the release of acid hydrolases into the cytoplasm.…”

Section: Immunotoxic Mechanism Of Bap and Chr In L Vannameimentioning

confidence: 61%

“…Once the PAHs are taken up by an organism, these PAHs undergo biotransformation reactions through two ways, during the reactions, reactive oxygen species (ROS) and inermediate hydrosoluble metabolites were stimulated to produce, and thereby damage biological macromolecules and tissue structures [31], which is another reason for the decrease of THC. Moreover, the haemocyte may participate in damage repair, resulting in a decrease of count in hemolymph [11]. Such a decrease in THC has also been reported in crustaceans as a result of the exposures to PAHs [26], PCBs [32] and ammonia-N [18].…”

Section: Immunotoxic Mechanism Of Bap and Chr In L Vannameimentioning

confidence: 68%

“…An effective immune response is important in themaintenance of the health, disease and survival of an organism [8]. PAHs can alter cellular function (viability and immune function) in various invertebrate species, such as bivalves [9][10][11] and crustaceans [12,13]. Therefore, immune function is important in assessing sublethal effect of contaminant exposure [14].…”

Section: Introductionmentioning

confidence: 99%

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Immunotoxic effect of Benzo[α]Pyrene and chrysene in juvenile white shrimp Litopenaeus vannamei

2014

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The effects of benzo(a)pyrene (Bap) (0.03, 0.3 and 3 μg L−1) and chrysene (CHR) (0.3, 2.1 and 14.7 μg L−1) on the function of the immune system of juvenile white shrimp Litopenaeus vannamei were determined under laboratory conditions. This included the total hemocyte count (THC) in the hemolymph, phagocytic activityand pro-phenoloxidase (pro-PO) activity of the hemocyte, phenoloxidase (PO) activity, α2-macroglobulin (α2-M) activity, bacteriolytic activity and antibacterial activity in the hemolymph. The results showed that BaP and CHR could inhibit the immune function of L. vannamei significantly under high concentration BaP and CHR exposure. The results of this study indicated that the immunotoxicity of PAHs in a descending order was BaP>CHR. Moreover, the results indicated the THC in hemolymph, pro-PO activity and phagocytic activity of hemocyte, and bacteriolytic activity in hemolymphcould be used as potentially suitable biomarkersfor early warning indication of PAHs toxicity, this could provide useful information for toxic risk assessment of environmental pollutants.

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Section: Effects Of Bap and Chr On Immune Parameterssupporting

confidence: 92%

Section: Effects Of Bap and Chr On Immune Parameterssupporting

confidence: 90%

Section: Immunotoxic Mechanism Of Bap and Chr In L Vannameimentioning

confidence: 61%

Section: Immunotoxic Mechanism Of Bap and Chr In L Vannameimentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

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Immunotoxic effect of Benzo[α]Pyrene and chrysene in juvenile white shrimp Litopenaeus vannamei

2014

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Seasonal variation and biogeochemical cycling of dimethylsulfide (DMS) and dimethylsulfoniopropionate (DMSP) in theYellowSea andBohaiSea

et al. 2014

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The concentrations of dimethylsulfide (DMS), dimethylsulfoniopropionate (DMSP) and chlorophyll a (Chl-a) as well as the size distribution of particulate DMSP (DMSPp) were determined in the Yellow Sea (YS) and Bohai Sea (BS) during two cruises from 1 to 20 November 2012 and from 21 June to 11 July 2013. Besides, the biological production and consumption rates of DMS and the degradation rates of dissolved DMSP (DMSPd) were also measured. The concentrations of DMS and DMSP showed a significant seasonal variation with higher values in summer, which corresponded well with the seasonal change of Chl-a in the study area. Both DMS and DMSPp concentrations were significantly correlated with Chl-a levels, implying that phytoplankton biomass might play an important role in controlling the distributions of DMS and DMSP in the study area. The size-fractionation research showed that nanophytoplankton (5-20 lm) contributed to most of Chl-a and DMSPp in autumn and summer. The average biological production and consumption rates of DMS during summer were 13.35 and 9.80 nmol L 21 d 21 , respectively, which were much higher than those during autumn. The degradation rates of DMSPd during summer ranged from 7.10 to 21.70 nmol L 21 d 21 , with an average of 14.71 nmol L 21 d 21 , which was nearly equal to the average biological production rate (13.35 nmol L 21 d 21 ) of DMS. The average sea-to-air flux of DMS in the YS and BS were 12.06 and 20.81 lmol m 22 d 21 in autumn and in summer, respectively, which were much higher than the values reported in the ocean.

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Effects of benzo(a)pyrene on differentially expressed genes and haemocyte parameters of the clam Venerupis philippinarum

et al. 2013

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In this study a suppression subtractive hybridisation method was employed to identify differentially expressed genes of the clam Venerupis philippinarum exposed to benzo(a)pyrene (BaP). Nineteen known transcripts and seven predicted proteins were found from the subtractive cDNA library of the clam, which could provide more sequence information for further study. Seven of the differentially expressed genes were selected for mRNA expression analysis. Real-time PCR analysis revealed that the expression level of the selected cDNAs of clams was up-regulated to varying degrees by different concentration of BaP. They are suggested as potential molecular biomarkers for polycyclic aromatic hydrocarbons (PAHs) pollution monitoring in aquatic ecosystems. In addition, haemocyte parameters were also measured, and a decrease of total haemocyte counts and suppression of antibacterial and bacteriolytic activities were detected in BaP-stressed clams. We suggest that the modulation of the expression of the selected genes caused by PAHs probably leads to the disturbance of the immune defense of the clam. Meanwhile, the adverse effects of PAHs on haemocyte parameters caused the suppression of the immune defense and susceptibility to infectious diseases. Therefore, it is inferred that PAHs pollutants could interact with components of the immune system and interferes with defense functions of the clam V. philippinarum.

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Immunotoxicity effect of benzo[α]pyrene on scallop Chlamys farreri

Cited by 18 publications

References 28 publications

Immunotoxic effect of Benzo[α]Pyrene and chrysene in juvenile white shrimp Litopenaeus vannamei

Immunotoxic effect of Benzo[α]Pyrene and chrysene in juvenile white shrimp Litopenaeus vannamei

Seasonal variation and biogeochemical cycling of dimethylsulfide (DMS) and dimethylsulfoniopropionate (DMSP) in theYellowSea andBohaiSea

Effects of benzo(a)pyrene on differentially expressed genes and haemocyte parameters of the clam Venerupis philippinarum

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