Immunotoxicity of microplastics and two persistent organic pollutants alone or in combination to a bivalve species

Tang, Yu; Rong, Jiahuan; Guan, Xinyi; Zha, Shanjie; Shi, Wei; Han, Yu; Du, Xueying; Wu, Fangzhu; Huang, Wei; Liu, Guangxu

doi:10.1016/j.envpol.2019.113845

Cited by 213 publications

(46 citation statements)

References 92 publications

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“…A total of 240 blood clams were randomly divided into control group (ASW), solvent control group (DMSO), and two Bap exposure (10 and 100 μg/L) groups. The chosen Bap concentration in this experiment was according to Su et al 6 and Tang et al 84 and represented at par with the low and high concentration, respectively. The experiment contained triple replicates and 20 individuals in each replicate.…”

Section: Methodsmentioning

confidence: 99%

Acute benzo[a]pyrene exposure induced oxidative stress, neurotoxicity and epigenetic change in blood clam Tegillarca granosa

Guo

Feng

et al. 2021

Sci Rep

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The blood clam (Tegillarca granosa) is being developed into a model bivalve mollusc for assessing and monitoring marine pollution on the offshore seabed. However, the information on the response of blood clam to PAHs, an organic pollutant usually deposited in submarine sediment, remains limited. Herein, we employed multiple biomarkers, including histological changes, oxidative stress, neurotoxicity and global DNA methylation, to investigate the effects of 10 and 100 μg/L Bap exposure on the blood clams under laboratory conditions, as well as the potential mechanisms. Acute Bap exposure can induce significant morphological abnormalities in gills as shown through hematoxylin–eosin (H.E) staining, providing an intuitive understanding on the effects of Bap on the structural organization of the blood clams. Meanwhile, the oxidative stress was significantly elevated as manifested by the increase of antioxidants activities of superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) and glutathione-s-transferase (GST), lipid peroxidation (LPO) level and 8-hydroxy-2′-deoxyguanosine (8-OHdG) content. The neurotoxicity was also strengthened by Bap toxicity manifested as inhibited acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) activities. In addition, the global DNA methylation level was investigated, and a significant DNA hypomethylation was observed in Bap exposed the blood clam. The correlation analysis showed that the global DNA methylation was negatively correlated with antioxidants (SOD, CAT and POD) activities, but positively correlated choline enzymes (AChE and ChAT) activities. These results collectively suggested that acute Bap exposure can cause damage in gills structures in the blood clam possibly by generating oxidative stress and neurotoxicity, and the global DNA methylation was inhibited to increase the transcriptional expression level of antioxidants genes and consequently elevate antioxidants activities against Bap toxicity. These results are hoped to shed some new light on the study of ecotoxicology effect of PAHs on marine bivalves.

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Section: Methodsmentioning

confidence: 99%

Acute benzo[a]pyrene exposure induced oxidative stress, neurotoxicity and epigenetic change in blood clam Tegillarca granosa

Guo

Feng

et al. 2021

Sci Rep

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“…In Mediterranean sea urchin, exposure to PS microbeads (10 μm and 4 5 μm, 10 particles/mL, for 24 h) increased the total coelomocyte count and the intracellular levels of reactive oxygen and nitrogen species, indicating a stress-related impact on these circulating immune cells [105]. In the bivalve mollusk Tegillarca granosa, two studies have shown that PS exposure (500 nm and 30 μm, 0.29 and 1 mg/L, during 14 and 4 days, respectively) leads to several disturbances in hemocytes, with notably a decrease in the cell count and in phagocytosis activity, and numerous variations in immune parameters related to oxidative stress, apoptosis, and the inflammatory response [109,110]. In both studies, PS nanoparticles caused more damage than PS microparticles did.…”

Section: In Vivo Immunotoxicity Of Nano-and Microplastics In Invertebmentioning

confidence: 99%

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

2020

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Background Together with poor biodegradability and insufficient recycling, the massive production and use of plastics have led to widespread environmental contamination by nano- and microplastics. These particles accumulate across ecosystems - even in the most remote habitats - and are transferred through food chains, leading to inevitable human ingestion, that adds to the highest one due to food processes and packaging. Objective The present review aimed at providing a comprehensive overview of current knowledge regarding the effects of nano- and microplastics on intestinal homeostasis. Methods We conducted a literature search focused on the in vivo effects of nano- and microplastics on gut epithelium and microbiota, as well as on immune response. Results Numerous animal studies have shown that exposure to nano- and microplastics leads to impairments in oxidative and inflammatory intestinal balance, and disruption of the gut’s epithelial permeability. Other notable effects of nano- and microplastic exposure include dysbiosis (changes in the gut microbiota) and immune cell toxicity. Moreover, microplastics contain additives, adsorb contaminants, and may promote the growth of bacterial pathogens on their surfaces: they are potential carriers of intestinal toxicants and pathogens that can potentially lead to further adverse effects. Conclusion Despite the scarcity of reports directly relevant to human, this review brings together a growing body of evidence showing that nano- and microplastic exposure disturbs the gut microbiota and critical intestinal functions. Such effects may promote the development of chronic immune disorders. Further investigation of this threat to human health is warranted.

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“…A great body of studies is nowadays starting to focus on the potential toxicity of MPs and to investigate their role as vector of HOCs (Endo et al, 2005;Teuten et al, 2007;Bakir et al, 2014;Chen et al, 2019;Tang et al, 2020). In this study, the overall evaluation of pollutants carried on…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Microplastics and their associated organic pollutants from the coastal waters of the central Adriatic Sea (Italy): Investigation of adipogenic effects in vitro

et al. 2021

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Immunotoxicity of microplastics and two persistent organic pollutants alone or in combination to a bivalve species

Cited by 213 publications

References 92 publications

Acute benzo[a]pyrene exposure induced oxidative stress, neurotoxicity and epigenetic change in blood clam Tegillarca granosa

Acute benzo[a]pyrene exposure induced oxidative stress, neurotoxicity and epigenetic change in blood clam Tegillarca granosa

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

Microplastics and their associated organic pollutants from the coastal waters of the central Adriatic Sea (Italy): Investigation of adipogenic effects in vitro

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