Immunotoxicological impact of occupational and environmental nanoparticles exposure: The influence of physical, chemical, and combined characteristics of the particles

Pedata, Paola; Petrarca, Claudia; Garzillo, Elpidio Maria; Gioacchino, Mario Di

doi:10.1177/0394632015608933

Cited by 20 publications

(11 citation statements)

References 98 publications

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“…Continuous activation of the immune system can potentially exacerbate the development of allergic and/or autoimmune diseases. On the other end of the spectrum, uncontrolled suppression of the immune system might result in increased incidence and severity of infectious diseases and cancer [98]. Therefore, understanding the immunomodulatory effect of NPs is an essential requirement to developing novel NPs for biological purposes.…”

Section: Current Challenges and Perspectivementioning

confidence: 99%

Effects of engineered nanoparticles on the innate immune system

Liu

Hardie

Zhang

et al. 2017

Seminars in Immunology

229

131

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Engineered nanoparticles (NPs) have broad applications in industry and nanomedicine. When NPs enter the body, interactions with the immune system are unavoidable. The innate immune system, a non-specific first line of defense against potential threats to the host, immediately interacts with introduced NPs and generates complicated immune responses. Depending on their physicochemical properties, NPs can interact with cells and proteins to stimulate or suppress the innate immune response, and similarly activate or avoid the complement system. NPs size, shape, hydrophobicity and surface modification are the main factors that influence the interactions between NPs and the innate immune system. In this review, we will focus on recent reports about the relationship between the physicochemical properties of NPs and their innate immune response, and their applications in immunotherapy.

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Section: Current Challenges and Perspectivementioning

confidence: 99%

Effects of engineered nanoparticles on the innate immune system

Liu

Hardie

Zhang

et al. 2017

Seminars in Immunology

229

131

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“…Therefore, evaluation of their immunotoxicity requires special consideration. Strategies, models, and approaches for studying nanoparticle effects on the immune system have been extensively discussed elsewhere [14–16]. Earlier publications have also covered the immunotoxicity of various types of engineered nanomaterials [13, 15], reviewed the biomedical utility of metallic nanoparticles [11, 17], and even attempted to get mechanistic insights into the cytotoxicity of iron oxide nanoparticles (IONPs) as well as to identify the potential contribution of the coating to the cytotoxicity [18].…”

Section: Introductionmentioning

confidence: 99%

Immunological effects of iron oxide nanoparticles and iron-based complex drug formulations: Therapeutic benefits, toxicity, mechanistic insights, and translational considerations

Shah

Dobrovolskaia

2018

Nanomedicine: Nanotechnology, Biology and Medicine

120

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Nanotechnology offers several advantages for drug delivery. However, there is the need for addressing potential safety concerns regarding the adverse health effects of these unique materials. Some such effects may occur due to undesirable interactions between nanoparticles and the immune system, and they may include hypersensitivity reactions, immunosuppression, and immunostimulation. While strategies, models, and approaches for studying the immunological safety of various engineered nanoparticles, including metal oxides, have been covered in the current literature, little attention has been given to the interactions between iron oxide-based nanomaterials and various components of the immune system. Here we provide a comprehensive review of studies investigating the effects of iron oxides and iron-based nanoparticles on various types of immune cells, highlight current gaps in the understanding of the structure-activity relationships of these materials, and propose a framework for capturing their immunotoxicity to streamline comparative studies between various types of iron-based formulations.

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“…Although delivering TLR ligands using NPs in fish is not a new concept, the NP used in the current study is unique. As opposed to most NPs, which have inherent immunotoxic or immunomodulatory activities within the host cells 33,34 , these phytoglycogen NPs were not able to induce innate immune responses on their own, nor did they induce cellular toxicity. These properties make this phytoglycogen NP a promising carrier for delivering immunomodulation agents in aquatic species.…”

Section: Discussionmentioning

confidence: 81%

Enhancing innate antiviral immune responses in rainbow trout by double stranded RNA delivered with cationic phytoglycogen nanoparticles

Alkie

Jong

Jenik

et al. 2019

Sci Rep

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Innate immunity is induced when pathogen-associated molecular patterns (PAMPs) bind host pattern recognition receptors (PRRs). Polyinosinic:polycytidylic acid [poly(I:C)] is a synthetic analogue of viral dsRNA that acts as a PAMP, inducing type I interferons (IFNs) in vertebrates. In the present study, the immunostimulatory effects of high molecular weight (HMW) poly(I:C) in rainbow trout cells were measured when bound to a cationic phytoglycogen nanoparticle (Nano-HMW). The physical characteristics of the nanoparticle itself, when bound to different lengths of dsRNA and when cell associated was evaluated. Optimal concentration and timing for innate immune stimulation was measured using the RTG-P1 reporter cell line. The immunostimulatory effects of HMW poly (I:C) was compared to Nano-HMW in vitro using the RTgutGC cell line cultured in a conventional monolayer or a transwell culture system. The ability of an activated intestinal epithelium to transmit an antiviral signal to macrophages was evaluated using a co-culture of RTgutGC cells and RTSll (a monocyte/macrophage cell). In all culture conditions, Nano-HMW was a more effective inducer of IFN-related antiviral immune responses compared to HMW poly (I:C) alone. This study introduces the use of cationic phytoglycogen nanoparticles as a novel delivery system for immunomodulatory molecules to enhance immune responses in aquatic vertebrates.

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Immunotoxicological impact of occupational and environmental nanoparticles exposure: The influence of physical, chemical, and combined characteristics of the particles

Cited by 20 publications

References 98 publications

Effects of engineered nanoparticles on the innate immune system

Effects of engineered nanoparticles on the innate immune system

Immunological effects of iron oxide nanoparticles and iron-based complex drug formulations: Therapeutic benefits, toxicity, mechanistic insights, and translational considerations

Enhancing innate antiviral immune responses in rainbow trout by double stranded RNA delivered with cationic phytoglycogen nanoparticles

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