Impact Analysis of the National Guidelines for Blood Donor Selection in India: A Single Center Study

Agnihotri, Naveen; Chaturvedi, Yatendra Mohan; Agnihotri, Ajju

doi:10.1007/s12288-019-01100-1

Cited by 6 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stressful lifestyle, distorted sleep cycles, body mass index and habits like alcohol, smoking plays a major role in young hypertensives [28–30]. With the implementation of Joint National Committee 7 guidelines for hypertension (140/90 mm Hg) as a cut‐off for blood donor selection (previously 160/100 mm Hg), hypertension is also emerging as a critical factor in donor deferral [31,32]. We noticed a reversal of pattern during the pandemic with more hypertension‐related deferral.…”

Section: Discussionmentioning

confidence: 99%

Impact of COVID‐19 on blood donor deferral patterns during the COVID‐19 pandemic: A retrospective analysis

et al. 2022

View full text Add to dashboard Cite

Background and Objectives Blood donor deferral is an essential tool for blood safety. The ongoing COVID‐19 pandemic has adversely affected blood transfusion services all over the world. But its impact on donor deferral rate and the pattern is unclear in light of the new donor deferral policy due to the COVID‐19 pandemic. Materials and Methods This retrospective study was divided into pre‐COVID and COVID (15 March 2019–14 March 2021). All the deferred donors were divided into six different categories: (1) medical causes, (2) surgical causes, (3) drugs and vaccination, (4) risk of transfusion‐transmitted diseases, (5) miscellaneous causes and (6) flu‐like symptoms. In addition, COVID‐related deferrals were also incorporated. All these above categories along with the donor demography were analysed by SPSS software version 25. Results The donor deferral rate was 17.03% and 12.74% during the pre‐COVID and COVID periods, respectively. During the pre‐COVID period, Category 3 deferrals and during COVID period, Category 6 deferrals were significantly higher. A reversal in pattern with increased blood pressure (40.2% vs. 24.04%) over‐riding low haemoglobin (34.77% vs. 55.5%) was noted in the Category 1 deferral during the COVID period. Category 1 deferral was more in middle‐aged adults as compared to young and old adults (p < 0.05). Among middle‐aged adults, deferral due to flu‐like symptoms was also significantly more during the COVID period (p < 0.05). Conclusion COVID‐19 significantly affected the donor pool and changed the pattern of donor deferral. Understanding donor deferral patterns may help in identifying targeted donor populations and planning donor recruitment strategies in future pandemic crises.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of COVID‐19 on blood donor deferral patterns during the COVID‐19 pandemic: A retrospective analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…We chose to use a murine model to minimize confounding factors that contribute to the “donor-variation effect” in human blood banking 11 . Examples include the differences in hemoglobin concentration by donor sex, age, and body mass; the heritable nature of redox metabolite levels such as glutathione; and even glycosylated hemoglobin levels in unsuspecting donors that lead to altered RBC morphology 37–39 . While murine coagulation pathways are largely comparable to human, differences do exist 40 .…”

Section: Discussionmentioning

confidence: 99%

Whole blood storage duration alters fibrinogen levels and thrombin formation

Chae,

Nguyen,

Archdeacon

et al. 2024

J Trauma Acute Care Surg

View full text Add to dashboard Cite

Introduction Whole blood resuscitation for hemorrhagic shock in trauma represents an opportunity to correct coagulopathy in trauma while also supplying red blood cells. The production of microvesicles in stored whole blood and their effect on its hemostatic parameters have not been described in previous literature. We hypothesized that microvesicles in aged stored whole blood are procoagulant and increase thrombin production via phosphatidylserine. Methods Whole blood was obtained from male C57BL/6 male mice and stored in anticoagulant solution for up to 10 days. At intervals, stored whole blood underwent examination with rotational thromboelastography and platelet poor plasma was prepared for analysis of thrombin generation. Microvesicles were prepared from 10 day old whole blood aliquots and added to fresh whole blood or platelet poor plasma to assess changes in coagulation and thrombin generation. Microvesicles were treated with recombinant mouse lactadherin prior to addition to plasma to inhibit phosphatidylserine’s role in thrombin generation. Results Aged murine whole blood had decreased fibrin clot formation compared to fresh samples with decreased plasma fibrinogen levels. Thrombin generation in plasma from aged blood increased over time of storage. The addition of microvesicles to fresh plasma resulted in increased thrombin generation compared to controls. When phosphatidylserine on microvesicles was blocked with lactadherin, there was no difference in the endogenous thrombin potential but the generation of thrombin was blunted with lower peak thrombin levels. Conclusions Cold storage of murine whole blood results in decreased fibrinogen levels and fibrin clot formation. Aged whole blood demonstrates increased thrombin generation and this is due in part to microvesicle production in stored whole blood. One mechanism by which microvesicles are procoagulant is by phosphatidylserine expression on their membranes. Level of Evidence Basic Science

show abstract

“…Trends in delayed blood donation rates in the student population, 2018-2022. As the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) lowered the threshold for diagnosis of hypertension to 140/90 mm Hg (previously 160/100 mm Hg), hypertension has gradually become a key factor in deferring blood donation (22,23). Abnormal blood pressure (BP) was identified as the second most important reason for delayed donation in the student population in this study, with a delay rate of 3.30%, accounting for 26.22% of all deferrals, which has shown a gradual upward trend over the past 5 years.…”

Section: Discussionmentioning

confidence: 99%

The influence of demographic and lifestyle factors on blood donation delay among student population: a retrospective study

Feng,

Yun,

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

ObjectiveThis study analysed blood donation deferral trends, reasons and demographic/lifestyle characteristics among students in Huzhou City. The aim was to understand the health status of students and reduce the deferral rate.MethodsData on blood donation deferral among students in Huzhou City from 2018 to 2022 were collected and analysed. Deferral trends and main reasons were investigated. Using demographic and lifestyle data from 2,619 cases in 2022, a risk prediction model for deferral was constructed.ResultsThe deferral rate among students in Huzhou City from 2018 to 2022 was 12.60% (p = 0.000, 95%CI: 12.14–13.06%), showing a significant increasing trend. Temporary deferral was the main reason, with alanine aminotransferase (ALT), blood pressure (BP) and haemoglobin (Hb) as the main deferral factors. ALT had a deferral rate of 5.23% (4.92–5.53%), BP 3.30% (3.06–3.55%), and Hb 2.92% (2.68–3.15%). Demographic and lifestyle characteristics in 2022 showed no significant differences between education level, household registration and deferral rate (p > 0.05). However, age, sex, blood donation history, sleep quality, diet and mental state had variable effects on ALT, BP, and Hb deferrals (p < 0.05). Logistic regression showed that sex, blood donation history, sleep quality, diet and mental status were independent risk factors for ALT deferral (p < 0.05), with odds ratios (ORs) of 5.057, 2.735, 1.594, 3.679, and 1.957, respectively. Age, blood donation history, sleep quality and mental state were independent risk factors for BP deferral (p < 0.05), with ORs of 0.256, 3.658, 6.042, and 1.812, respectively. Gender, blood donation history and diet were independent risk factors for Hb deferral (p < 0.05), with ORs of 0.244, 0.542, and 3.103, respectively.ConclusionStudents’ health problems require attention. Effective health education should improve self-health management and pre-donation health behaviour to encourage regular blood donation.

show abstract

Impact Analysis of the National Guidelines for Blood Donor Selection in India: A Single Center Study

Cited by 6 publications

References 11 publications

Impact of COVID‐19 on blood donor deferral patterns during the COVID‐19 pandemic: A retrospective analysis

Impact of COVID‐19 on blood donor deferral patterns during the COVID‐19 pandemic: A retrospective analysis

Whole blood storage duration alters fibrinogen levels and thrombin formation

The influence of demographic and lifestyle factors on blood donation delay among student population: a retrospective study

Contact Info

Product

Resources

About