Impact and residence time of oxytetracycline in the sea urchin, Psammechinus miliaris, a potential aquaculture species

Campbell, Dirk A; Pantazis, Panagiotis; Kelly, Maeve

doi:10.1016/s0044-8486(01)00600-7

Cited by 26 publications

(13 citation statements)

References 20 publications

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“…Freshwater (e.g., green algae S. capricornutum, rotifer Brachionus calyciflorus, and cladoceran Ceriodaphnia dubia) and marine species [e.g., shrimp Penaeus vannamei (Boxall et al 2004;Isidori et al 2005)] as well as green algae Rhodomonas salina (Holten-Lützhøft et al 1999) were found to be more sensitive to OTC (EC 50 = 0.061-0.18 mg/l) than marine bacteria [e.g., Vibrio fischeri (Isidori et al 2005;Lalumera et al 2004;Park and Choi 2008)], sea urchins (e.g., Psammechinus miliaris [Campbell et al 2001]), or larvae of the marine fish Morone saxatilis (Boxall et al 2004) (EC 50 C 60 mg/l). However, in the case of bacteria, the apparently low sensitivity may be due to the short exposure time used in the toxicity test rather than to a real lack of sensitivity (Thomulka et al 1993;Backhaus and Grimme 1999;van der Grinten et al 2010).…”

Section: Otcmentioning

confidence: 99%

Assessing the Toxicity of Chemical Compounds Associated With Land-Based Marine Fish Farms: The Sea Urchin Embryo Bioassay With Paracentrotus lividus and Arbacia lixula

Carballeira¹,

Orte²,

Viana

et al. 2012

Arch Environ Contam Toxicol

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In aquaculture, disinfection of facilities, prevention of fish diseases, and stimulation of fish growth are priority goals and the most important sources of toxic substances to the environment, together with excretory products from fish. In the present study, embryos of two species of sea urchin (Paracentrotus lividus and Arbacia lixula) were exposed to serial dilutions of six antibiotics (amoxicillin (AMOX), ampicillin, flumequine (FLU), oxytetracycline (OTC), streptomycin (ST), and sulfadiazine [SFD]) and two disinfectants (sodium hypochlorite (NaClO) and formaldehyde [CH(2)O]). Alterations in larval development were studied, and the effective concentrations (ECs) were calculated to evaluate the toxicity of the substances. Both species showed similar sensitivities to all substances tested. Disinfectants (EC(50) = 1.78 and 1.79 mg/l for CH(2)O; EC(50) = 10.15 and 11.1 mg/l for NaClO) were found to be more toxic than antibiotics. AMOX, OTC, and ST caused <20 % of alterations, even at the highest concentrations tested. FLU was the most toxic to P. lividus (EC(50) = 31.0 mg/l) and SFD to A. lixula (EC(50) = 12.7 mg/l). The sea urchin bioassay should be considered within toxicity assessment-monitoring plans because of the sensitivity of larvae to disinfectants.

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Section: Otcmentioning

confidence: 99%

Assessing the Toxicity of Chemical Compounds Associated With Land-Based Marine Fish Farms: The Sea Urchin Embryo Bioassay With Paracentrotus lividus and Arbacia lixula

Carballeira¹,

Orte²,

Viana

et al. 2012

Arch Environ Contam Toxicol

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“…In addition, it is important to obtain knowledge of the residue depletion of CAP in fish for comprehensively evaluating the human risk of drug residue and the environmental impact of the drug. Residue studies on fish tissues resulting from treatment with antibiotic have been reported in many aquatic species, but most studies focused on treatment with oxytetracycline (Park, Lightner & Milner 1995; Malvisi, Rocca, Anfossi & Giorgetti 1996; Campbell, Pantazis & Kelly 2001; Meinertz, Gaikowski, Stehly, Gingerich & Evered 2001). There are few reports on depletion and residue studies of CAP in fish tissues (Li 1998; Tang, Wang & Li 2003; Wang, Lin, Xue & Khalid 2004).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of chloramphenicol in carp (Cyprinus carpio L.) after drug administration

Huang

Sun

et al. 2006

Aquaculture Res

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Chloramphenicol (CAP) is a banned substance in fish farming; yet, residues are sometimes detected in farmed fish products. Therefore, it is important that tissue distribution and elimination rates of CAP are measured to allow monitoring of fish farms. The tissue distribution and residue of CAP in carp (Cyprinus carpio L.) after muscle injection was investigated. Chloramphenicol concentrations were determined using high‐performance liquid chromatography. Pharmacokinetics were used for the studies of CAP residue and the results showed that the CAP was easily assimilated in the liver, serum and gill, with the absorption rates of 6383, 3.02 and 1.39 h−1, respectively, following a single‐dose injection of 80 mg kg bw−1. The elimination half‐lives (t1/2) were 22.28, 15.47, 14.87, 9.28 and 5.32 h for the liver, serum, gill, muscle and kidney respectively. The t1/2 after 5 days of multi‐doses of repeated CAP injection with 40 mg kg bw−1 was 1.09, 0.887, 0.872, 0.476 and 0.617 days for the five tissues respectively. The results validated that CAP in the liver, serum and gill could be markers for CAP residue analysis.

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“…However, Andrieu, Rico, Phu, Huong, Phuong and Van den Brink () reported that concentration of enrofloxacin in the sediments of fish pond was 7848 times higher than in water. These residues may originate from unconsumed medicated feeds, the leaching of antibiotics prior to consumption, and the release of excrements and other metabolic residues from the medicated animals (Björklund, Räbergh & Bylund ; Kerry, Hiney, Coyne, NicGabhainn, Gilroy, Cazabon & Smith ; Campbell, Pantazis & Kelly ; Tendencia & De La Peña ). SM 2 has a log octanol/water partition coefficient varying between 1.4 and 3.9 at different pHs (Liu, Cui, Zhang, Zhang & Zhang ), and tends to be adsorbed in sediments with a medium sorption potential.…”

Section: Discussionmentioning

confidence: 99%

Environmental fate and pharmacokinetics of sulphamethazine inFenneropenaeus chinensisshrimp production systems after oral administration

Sun

Zhai

et al. 2015

Aquac Res

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The antimicrobial sulphamethazine is widely used in aquaculture for the prevention and treatment of bacterial diseases. Residues of sulphamethazine have been detected in aquatic environments and in edible tissues of aquaculture fish and shrimps at relatively low, but detectable concentrations. Detailed information on the environmental fate and pharmacokinetics of sulphamethazine in aquaculture species is essential to predict possible ecological risks and to provide recommendations on appropriate dosages and withdrawal periods. In this study we investigated the distribution of sulphamethazine in water and sediments of Fenneropenaeus chinensis shrimp ponds treated with 50, 100 and 150 mg kg−1·bw of sulphamethazine for 5 days and measured the uptake and elimination dynamics of sulphamethazine in different shrimp organs and tissues. Results of the HPLC analysis showed highest sulphamethazine concentrations in shrimp tissues, followed by sediments and water. The rank order of the mean concentrations of sulphamethazine in shrimp tissues and organs was hepatopancreas> plasma≈ stomach> muscle≈ gill≈ intestine> carapace. The results also demonstrated a significant dose‐dependent accumulation of sulphamethazine in the different biological and environmental compartments. Sulphamethazine decreased gradually with the time in all of the three compartments. The mean half‐life of sulphamethazine in sediment and water was 2.15 and 2.17 days respectively. A withdrawal period of 10 days or more is proposed for F. chinensis orally treated with sulphamethazine in order to meet the current food safety standards.

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Impact and residence time of oxytetracycline in the sea urchin, Psammechinus miliaris, a potential aquaculture species

Cited by 26 publications

References 20 publications

Assessing the Toxicity of Chemical Compounds Associated With Land-Based Marine Fish Farms: The Sea Urchin Embryo Bioassay With Paracentrotus lividus and Arbacia lixula

Assessing the Toxicity of Chemical Compounds Associated With Land-Based Marine Fish Farms: The Sea Urchin Embryo Bioassay With Paracentrotus lividus and Arbacia lixula

Pharmacokinetics of chloramphenicol in carp (Cyprinus carpio L.) after drug administration

Environmental fate and pharmacokinetics of sulphamethazine inFenneropenaeus chinensisshrimp production systems after oral administration

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