Impact de l'infection VIH sur l'infection palustre chez l'adulte

Martin‐Blondel, Guillaume; Barry, Mamadou; Porte, Lydie; Busato, Florian; Massip, Patrice; Benoit‐Vical, Françoise; Berry, Antoine; Marchou, B.

doi:10.1016/j.medmal.2007.03.018

Cited by 6 publications

(2 citation statements)

References 57 publications

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“…Malaria is known for its influence on HIV infection [6]- [10]. A Zambian study has reported that patients who are co-infected have a higher viral load [8] and low CD4 count [11].…”

Section: Introductionmentioning

confidence: 99%

Immunological, Virological, Parasitic and Biological Profile of Malaria/HIV Co-Infection in 18 Years Old and Above Patients in Lubumbashi (DR Congo)

Kakisingi¹,

Mukuku²,

Manika³

et al. 2016

OALib

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Introduction: Malaria infection and HIV infection are major public health issues in several parts of the world. Together they have caused more than a million deaths per year. Africa, and Sub-Saharan in particular are the most affected. Our study objective is to determine the prevalence of Malaria/HIV co-infection and describe its immunological, virological, parasitic and biological characteristics. Methodology: This is a descriptive, transversal and multi centric study done on 18 years old and above HIV positive patients, for a period extending from December 2008 to October 2009 in 5 different HIV treatment centres. Parameters studied were gender, age, CD4 count, viral load, parasite density and haemoglobin level. The HIV diagnosis was made according to the AIDS National Program and malaria according to the Malaria National Program. Statistic analyses were done using Epi Info 7 software and the Yates corrected Chi Square test or the Fischer Exact test (when recommended) was used to check any link between different parameters studied. Statistical significance was fixed at <0.05. Results: 405 HIV seropositive patients were compiled. The malaria prevalence in these patients was 6.9%. Majority of co-infected patients were aged between 26 and 49 years (67.9%), and had a CD4 count <200 μl (67.9%), a parasitic density <10,000 trophozoites/μl (75%) and an Hb level <11 g/dl. With regards to correlations between co-infected patients parasitic density and the CD4 count, viral load and Hb level, none of the studied parameters showed any statistic significance difference. Conclusion: A prevalence of 6.9% among HIV/malaria co-infected patients and 67.7% of these patients had a CD4 count less than 200 cells/μl. Thus, both national programs must promote an early testing for HIV infected patients and reinforce preventive measures in the management of malaria. C. Kakisingi et al.OALibJ |

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“…Malaria is known for its influence on HIV infection [6]- [10]. A Zambian study has reported that patients who are co-infected have a higher viral load [8] and low CD4 count [11].…”

Section: Introductionmentioning

confidence: 99%

Immunological, Virological, Parasitic and Biological Profile of Malaria/HIV Co-Infection in 18 Years Old and Above Patients in Lubumbashi (DR Congo)

Kakisingi¹,

Mukuku²,

Manika³

et al. 2016

OALib

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“…The profound impact of these infections on the immune system is generating interest in the scientific community [2]. Indeed, previous studies reported that HIV infection would be responsible for an increased incidence of malaria attacks and an increase in parasitaemia [3][4][5][6][7][8]. However, this finding is not shared by all, in fact, some authors have been reporting a low malaria prevalence (11.4%) in children infected with HIV compared to HIV-negative children (27.6%) [9].…”

Section: Introductionmentioning

confidence: 99%

Coinfection HIV and Malaria in Department of Paediatrics of the University Hospital Souro Sanou

Y¹,

R²

2015

J Hematol Thrombo

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Introduction: Malaria and HIV are the leading causes of mortality and morbidity in sub-Saharan Africa. The interaction of these two pathologies raises fundamental issues as well as therapeutic. This study seeks a better understanding of the clinical profile of coinfected biological and therapeutic HIV-Malaria in Children's Hospital Pediatrique du jour Day Centre Hospital Universitaire Souro Sanou (CHUSS) Bobo-Dioulasso.Methodology: It about a cross-sectional study with prospective and retrospective aspects. Included, were patients infected with HIV and followed in the service whose clinical and laboratory diagnosis of malaria had been performed and/or patients with whom the diagnosis of co-infection was done with the regression of a medical consultation following the consent of the legal representative. Results:The prevalence of coinfection was 3.09%. The clinical signs of severity were dominated by impaired consciousness, convulsions and dehydration. As for biological signs, anemia was found in 65% of patients; leukocytosis was found in 19.6% of coinfected and thrombocytopenia in 9.3% of cases. HIV-1 was the most encountered serotype and immunocompetent patients accounted for 70.7% of coinfected. Pharmaco therapeutic groups were mainly administered antimalarial (100% of cases), analgesics-antipyretics (79.6% of cases), ART (48.1% of cases), antibiotics, especially cotrimoxazole (21.3% cases). Conclusion:Immunosuppression induced by HIV infection did not appear to be associated with the frequency of occurrence of malaria. Chemo malaria prophylaxis in children living with HIV is not necessary. Consequently, malaria as a reason for consultation could be a gateway for the recruitment of children infected with HIV.

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