Impact Factors and the Optimal Parameter of Acoustic Structure Quantification in the Assessment of Liver Fibrosis

Huang, Yang; Liu, Guangjian; Liao, Bing; Huang, Guangliang; Liang, Jing; Zhou, Luyao; Wang, Fen; Wei, Li; Xie, Xiaoyan; Wang, Wei; Lü, Ming-De

doi:10.1016/j.ultrasmedbio.2015.05.006

Cited by 18 publications

(11 citation statements)

References 23 publications

(35 reference statements)

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“…Thus, the ASQ-related problems may be encountered when using Nakagami imaging for assessing liver fibrosis. For instance, the lack of a standardized analysis protocol may yield inconsistent results9. A coexisting hepatic steatosis may lead to interferences affecting fibrosis detection3940.…”

Section: Discussionmentioning

confidence: 99%

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Acoustic structure quantification by using ultrasound Nakagami imaging for assessing liver fibrosis

Tsui

Tai

et al. 2016

Sci Rep

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Acoustic structure quantification (ASQ) is a recently developed technique widely used for detecting liver fibrosis. Ultrasound Nakagami parametric imaging based on the Nakagami distribution has been widely used to model echo amplitude distribution for tissue characterization. We explored the feasibility of using ultrasound Nakagami imaging as a model-based ASQ technique for assessing liver fibrosis. Standard ultrasound examinations were performed on 19 healthy volunteers and 91 patients with chronic hepatitis B and C (n = 110). Liver biopsy and ultrasound Nakagami imaging analysis were conducted to compare the METAVIR score and Nakagami parameter. The diagnostic value of ultrasound Nakagami imaging was evaluated using receiver operating characteristic (ROC) curves. The Nakagami parameter obtained through ultrasound Nakagami imaging decreased with an increase in the METAVIR score (p < 0.0001), representing an increase in the extent of pre-Rayleigh statistics for echo amplitude distribution. The area under the ROC curve (AUROC) was 0.88 for the diagnosis of any degree of fibrosis (≥F1), whereas it was 0.84, 0.69, and 0.67 for ≥F2, ≥F3, and ≥F4, respectively. Ultrasound Nakagami imaging is a model-based ASQ technique that can be beneficial for the clinical diagnosis of early liver fibrosis.

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Section: Discussionmentioning

confidence: 99%

“…The acoustic structure quantification (ASQ) technique has recently gained attention as a tool for characterizing liver parenchyma578910. ASQ is performed on a basic pulse-echo ultrasound grayscale system for characterizing tissues through the statistical analysis of the acquired ultrasound echo signals11.…”

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confidence: 99%

Acoustic structure quantification by using ultrasound Nakagami imaging for assessing liver fibrosis

Tsui

Tai

et al. 2016

Sci Rep

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“…Hence, SWE is now considered a useful tool for staging liver fibrosis noninvasively. Most liver-stiffness measurements reported in the literature were obtained using a breath-hold technique to minimize potential artifacts and uncertainties due to breathing movements during the measurement of the shear-wave velocity [5][6][7]. That context was totally justified in early elastography studies based on strain imaging, because accurate estimation of the displacement field induced by the compressive force required the absence of any respiratory movement between the pre-and post-compressive states.…”

Section: Introductionmentioning

confidence: 99%

Does motion affect liver stiffness estimates in shear wave elastography? Phantom and clinical study

Pellot‐Barakat

Chami

Corréas

et al. 2016

European Journal of Radiology

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International audienceThis study was undertaken to evaluate the impact of free-breathing (FB) vs. Apnea on Shear-wave elastography (SWE) measurements.Quantitative liver-stiffness measurements were obtained during FB and Apnea for 97 patients with various body-morphologies and liver textures. Quality indexes of FB and Apnea elasticity maps (percentage of non-filling (PNF), temporal (TV) and spatial (SV) variabilities) were computed. SWE measurements were also obtained from an homogeneous phantom at rest and during a mechanically-induced motion.Liver-stiffness values estimated from FB and Apnea acquisitions were correlated, particularly for homogeneous livers (r = 0.76, P < 0.001) and favorable body-morphologies (r = 0.68, P < 0.001). However FB values were consistently 20–25% lower than Apnea ones (P < 0.001). FB also systematically resulted in degradation of TV (P < 0.005) and PNF (P < 0.001) compared to Apnea but had no impact on SV. With the phantom, no differences between SWE measurements at rest and during motion were observed.Apnea and FB measurements are highly correlated, although FB data quality is degraded compared to Apnea and estimated stiffness in FB is systematically lower than in Apnea. These discrepancies between rest and motion states were observed for patients but not for phantom data, suggesting that patient breath-holding impacts liver stiffness

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“…Besides ultrasound Nakagami imaging, the acoustic structure quantification (ASQ) technique has also recently gained attention as a tool for tissue characterization [ 23 – 25 ]. In ASQ, a focal disturbance (FD) ratio is defined from the areas under the histograms of two statistical parameters calculated using the average and variance of the echo signal amplitude.…”

Section: Discussionmentioning

confidence: 99%

Effect of ultrasound frequency on the Nakagami statistics of human liver tissues

et al. 2017

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The analysis of the backscattered statistics using the Nakagami parameter is an emerging ultrasound technique for assessing hepatic steatosis and fibrosis. Previous studies indicated that the echo amplitude distribution of a normal liver follows the Rayleigh distribution (the Nakagami parameter m is close to 1). However, using different frequencies may change the backscattered statistics of normal livers. This study explored the frequency dependence of the backscattered statistics in human livers and then discussed the sources of ultrasound scattering in the liver. A total of 30 healthy participants were enrolled to undergo a standard care ultrasound examination on the liver, which is a natural model containing diffuse and coherent scatterers. The liver of each volunteer was scanned from the right intercostal view to obtain image raw data at different central frequencies ranging from 2 to 3.5 MHz. Phantoms with diffuse scatterers only were also made to perform ultrasound scanning using the same protocol for comparisons with clinical data. The Nakagami parameter–frequency correlation was evaluated using Pearson correlation analysis. The median and interquartile range of the Nakagami parameter obtained from livers was 1.00 (0.98–1.05) for 2 MHz, 0.93 (0.89–0.98) for 2.3 MHz, 0.87 (0.84–0.92) for 2.5 MHz, 0.82 (0.77–0.88) for 3.3 MHz, and 0.81 (0.76–0.88) for 3.5 MHz. The Nakagami parameter decreased with the increasing central frequency (r = −0.67, p < 0.0001). However, the effect of ultrasound frequency on the statistical distribution of the backscattered envelopes was not found in the phantom results (r = −0.147, p = 0.0727). The current results demonstrated that the backscattered statistics of normal livers is frequency-dependent. Moreover, the coherent scatterers may be the primary factor to dominate the frequency dependence of the backscattered statistics in a liver.

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Impact Factors and the Optimal Parameter of Acoustic Structure Quantification in the Assessment of Liver Fibrosis

Cited by 18 publications

References 23 publications

Acoustic structure quantification by using ultrasound Nakagami imaging for assessing liver fibrosis

Acoustic structure quantification by using ultrasound Nakagami imaging for assessing liver fibrosis

Does motion affect liver stiffness estimates in shear wave elastography? Phantom and clinical study

Effect of ultrasound frequency on the Nakagami statistics of human liver tissues

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